-
2
-
-
0030749434
-
Therapeutic drug monitoring opportunities in cancer therapy
-
McLeod HL: Therapeutic drug monitoring opportunities in cancer therapy. Pharmacol Ther 74:39-54, 1997
-
(1997)
Pharmacol Ther
, vol.74
, pp. 39-54
-
-
McLeod, H.L.1
-
3
-
-
0031015454
-
Fluorouracil in colorectal cancer a tale of two drugs: Implications for biochemical modulation
-
Sobrero AF, Aschele C, Bertino JR: Fluorouracil in colorectal cancer a tale of two drugs: Implications for biochemical modulation. J Clin Oncol 15:368-381, 1997
-
(1997)
J Clin Oncol
, vol.15
, pp. 368-381
-
-
Sobrero, A.F.1
Aschele, C.2
Bertino, J.R.3
-
4
-
-
0029856893
-
Development of treatment for advanced colorectal cancer: Infusional 5-FU and the role of new agents
-
Schmoll HJ: Development of treatment for advanced colorectal cancer: Infusional 5-FU and the role of new agents. Eur J Cancer 32:S18-S22, 1996(suppl 5)
-
(1996)
Eur J Cancer
, vol.32
, Issue.SUPPL. 5
-
-
Schmoll, H.J.1
-
5
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
-
Heggie GD, Sommadossi JP, Cross DS, et al: Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 47:2203-2206, 1987
-
(1987)
Cancer Res
, vol.47
, pp. 2203-2206
-
-
Heggie, G.D.1
Sommadossi, J.P.2
Cross, D.S.3
-
6
-
-
0031859489
-
Oral chemotherapy: Rationale and future directions
-
DeMario MD, Ratain MJ: Oral chemotherapy: Rationale and future directions. J Clin Oncol 16:2557-2567, 1998
-
(1998)
J Clin Oncol
, vol.16
, pp. 2557-2567
-
-
DeMario, M.D.1
Ratain, M.J.2
-
7
-
-
0031105419
-
A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy
-
Nightingale CE, Norman A, Cunningham D, et al: A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy. Eur J Cancer 33:398-403, 1997
-
(1997)
Eur J Cancer
, vol.33
, pp. 398-403
-
-
Nightingale, C.E.1
Norman, A.2
Cunningham, D.3
-
8
-
-
0028982820
-
Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity
-
Etienne MC, Cheradame S, Fischel JL, et al: Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 13:1663-1670, 1995
-
(1995)
J Clin Oncol
, vol.13
, pp. 1663-1670
-
-
Etienne, M.C.1
Cheradame, S.2
Fischel, J.L.3
-
9
-
-
0031973816
-
Characterisation of dihydropyrimidine dehydrogenase in human colorectal tumors
-
McLeod HL, Sludden J, Murray GI, et al: Characterisation of dihydropyrimidine dehydrogenase in human colorectal tumors. Br J Cancer 77:461-465, 1998
-
(1998)
Br J Cancer
, vol.77
, pp. 461-465
-
-
McLeod, H.L.1
Sludden, J.2
Murray, G.I.3
-
10
-
-
0030988930
-
Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: Implication in 5-fluorouracil-based chemotherapy
-
Jiang WQ, Lu ZH, He YJ, et al: Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: Implication in 5-fluorouracil-based chemotherapy. Clin Cancer Res 3:395-399, 1997
-
(1997)
Clin Cancer Res
, vol.3
, pp. 395-399
-
-
Jiang, W.Q.1
Lu, Z.H.2
He, Y.J.3
-
11
-
-
0027489763
-
5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-FU
-
Baccanari DP, Davis DT, Knick VC, et al: 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-FU. Proc Natl Acad Sci USA 90:11064-11068, 1993
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11064-11068
-
-
Baccanari, D.P.1
Davis, D.T.2
Knick, V.C.3
-
12
-
-
0028920324
-
Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil
-
Spector T, Cao S, Rustum YM, et al: Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. Cancer Res 55:1239-1241, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 1239-1241
-
-
Spector, T.1
Cao, S.2
Rustum, Y.M.3
-
13
-
-
0028281781
-
5-Ethynyluracil (776C85): Modulation of 5-FU efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
-
Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85): Modulation of 5-FU efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 54:1507-1510, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 1507-1510
-
-
Cao, S.1
Rustum, Y.M.2
Spector, T.3
-
14
-
-
0026701936
-
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethylyluracil
-
Porter DJT, Chestnut WG, Merrill BM, et al: Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethylyluracil. J Biol Chem 267:5236-5242, 1992
-
(1992)
J Biol Chem
, vol.267
, pp. 5236-5242
-
-
Porter, D.J.T.1
Chestnut, W.G.2
Merrill, B.M.3
-
15
-
-
10544243363
-
Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients with 776C85, an inactivator of dihydropyrimidine dehydrogenase
-
Baker SD, Khor SP, Adjei AA, et al: Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 14:3085-3096, 1996
-
(1996)
J Clin Oncol
, vol.14
, pp. 3085-3096
-
-
Baker, S.D.1
Khor, S.P.2
Adjei, A.A.3
-
16
-
-
0031900670
-
Phase I clinical and pharmacological study of eniluracil plus fluorouracil in patients with advanced cancer
-
Schilsky RL, Hohneker J, Ratain MJ, et al: Phase I clinical and pharmacological study of eniluracil plus fluorouracil in patients with advanced cancer. J Clin Oncol 16:1450-1457, 1998
-
(1998)
J Clin Oncol
, vol.16
, pp. 1450-1457
-
-
Schilsky, R.L.1
Hohneker, J.2
Ratain, M.J.3
-
17
-
-
0027135995
-
5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
-
Spector T, Harrington JA, Parker DJ: 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem Pharmacol 46:2243-2248, 1993
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 2243-2248
-
-
Spector, T.1
Harrington, J.A.2
Parker, D.J.3
-
18
-
-
0029758307
-
Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity
-
McLeod HL, Keith WN: Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity. Br J Cancer 74:508-512, 1996
-
(1996)
Br J Cancer
, vol.74
, pp. 508-512
-
-
McLeod, H.L.1
Keith, W.N.2
-
19
-
-
0027462113
-
Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation
-
van Gennip AH, Busch S, Elzinga L, et al: Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation. Clin Chem 39:380-385, 1993
-
(1993)
Clin Chem
, vol.39
, pp. 380-385
-
-
Van Gennip, A.H.1
Busch, S.2
Elzinga, L.3
-
20
-
-
0025990479
-
Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome
-
Harris BE, Carpenter JT, Diasio RB: Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome. Cancer 68:499-501, 1991
-
(1991)
Cancer
, vol.68
, pp. 499-501
-
-
Harris, B.E.1
Carpenter, J.T.2
Diasio, R.B.3
-
21
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X, McLeod HL, McMurrough J, et al: Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 98:610-615, 1996
-
(1996)
J Clin Invest
, vol.98
, pp. 610-615
-
-
Wei, X.1
McLeod, H.L.2
McMurrough, J.3
-
22
-
-
0028357629
-
Relationship between fluorouracil systemic exposure and tumor response and patient survival
-
Milano G, Etienne MC, Renee N, et al: Relationship between fluorouracil systemic exposure and tumor response and patient survival. J Clin Oncol 12:1291-1295, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 1291-1295
-
-
Milano, G.1
Etienne, M.C.2
Renee, N.3
-
23
-
-
0028097137
-
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
-
Beck A, Etienne MC, Cheradame S, et al: A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur J Cancer 30:1517-1522, 1994
-
(1994)
Eur J Cancer
, vol.30
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Cheradame, S.3
-
24
-
-
0026045814
-
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa
-
Peters GJ, van Groeningen CJ, Laurensse EJ, et al: A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer 68:1903-1909, 1991
-
(1991)
Cancer
, vol.68
, pp. 1903-1909
-
-
Peters, G.J.1
Van Groeningen, C.J.2
Laurensse, E.J.3
-
25
-
-
0025351196
-
Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas
-
Maehara Y, Moriguchi S, Emi Y, et al: Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas. Cancer 66:156-161, 1990
-
(1990)
Cancer
, vol.66
, pp. 156-161
-
-
Maehara, Y.1
Moriguchi, S.2
Emi, Y.3
-
26
-
-
0000419698
-
A phase II open-label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776c85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC)
-
abstr 1083
-
Mani S, Beck T, Chevlen E, et al: A phase II open-label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC). Proc Am Soc Clin Oncol 17:281a, 1998 (abstr 1083)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Mani, S.1
Beck, T.2
Chevlen, E.3
|