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Volumn 17, Issue 8, 1999, Pages 2439-2445

Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYLURACIL; DIHYDROPYRIMIDINE DEHYDROGENASE; MESSENGER RNA; PYRIMIDINE; URACIL;

EID: 0032784111     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.8.2439     Document Type: Article
Times cited : (53)

References (26)
  • 2
    • 0030749434 scopus 로고    scopus 로고
    • Therapeutic drug monitoring opportunities in cancer therapy
    • McLeod HL: Therapeutic drug monitoring opportunities in cancer therapy. Pharmacol Ther 74:39-54, 1997
    • (1997) Pharmacol Ther , vol.74 , pp. 39-54
    • McLeod, H.L.1
  • 3
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer a tale of two drugs: Implications for biochemical modulation
    • Sobrero AF, Aschele C, Bertino JR: Fluorouracil in colorectal cancer a tale of two drugs: Implications for biochemical modulation. J Clin Oncol 15:368-381, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 4
    • 0029856893 scopus 로고    scopus 로고
    • Development of treatment for advanced colorectal cancer: Infusional 5-FU and the role of new agents
    • Schmoll HJ: Development of treatment for advanced colorectal cancer: Infusional 5-FU and the role of new agents. Eur J Cancer 32:S18-S22, 1996(suppl 5)
    • (1996) Eur J Cancer , vol.32 , Issue.SUPPL. 5
    • Schmoll, H.J.1
  • 5
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD, Sommadossi JP, Cross DS, et al: Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 47:2203-2206, 1987
    • (1987) Cancer Res , vol.47 , pp. 2203-2206
    • Heggie, G.D.1    Sommadossi, J.P.2    Cross, D.S.3
  • 6
    • 0031859489 scopus 로고    scopus 로고
    • Oral chemotherapy: Rationale and future directions
    • DeMario MD, Ratain MJ: Oral chemotherapy: Rationale and future directions. J Clin Oncol 16:2557-2567, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 2557-2567
    • DeMario, M.D.1    Ratain, M.J.2
  • 7
    • 0031105419 scopus 로고    scopus 로고
    • A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy
    • Nightingale CE, Norman A, Cunningham D, et al: A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy. Eur J Cancer 33:398-403, 1997
    • (1997) Eur J Cancer , vol.33 , pp. 398-403
    • Nightingale, C.E.1    Norman, A.2    Cunningham, D.3
  • 8
    • 0028982820 scopus 로고
    • Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity
    • Etienne MC, Cheradame S, Fischel JL, et al: Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 13:1663-1670, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 1663-1670
    • Etienne, M.C.1    Cheradame, S.2    Fischel, J.L.3
  • 9
    • 0031973816 scopus 로고    scopus 로고
    • Characterisation of dihydropyrimidine dehydrogenase in human colorectal tumors
    • McLeod HL, Sludden J, Murray GI, et al: Characterisation of dihydropyrimidine dehydrogenase in human colorectal tumors. Br J Cancer 77:461-465, 1998
    • (1998) Br J Cancer , vol.77 , pp. 461-465
    • McLeod, H.L.1    Sludden, J.2    Murray, G.I.3
  • 10
    • 0030988930 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: Implication in 5-fluorouracil-based chemotherapy
    • Jiang WQ, Lu ZH, He YJ, et al: Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: Implication in 5-fluorouracil-based chemotherapy. Clin Cancer Res 3:395-399, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 395-399
    • Jiang, W.Q.1    Lu, Z.H.2    He, Y.J.3
  • 11
    • 0027489763 scopus 로고
    • 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-FU
    • Baccanari DP, Davis DT, Knick VC, et al: 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-FU. Proc Natl Acad Sci USA 90:11064-11068, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11064-11068
    • Baccanari, D.P.1    Davis, D.T.2    Knick, V.C.3
  • 12
    • 0028920324 scopus 로고
    • Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil
    • Spector T, Cao S, Rustum YM, et al: Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. Cancer Res 55:1239-1241, 1995
    • (1995) Cancer Res , vol.55 , pp. 1239-1241
    • Spector, T.1    Cao, S.2    Rustum, Y.M.3
  • 13
    • 0028281781 scopus 로고
    • 5-Ethynyluracil (776C85): Modulation of 5-FU efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85): Modulation of 5-FU efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 54:1507-1510, 1994
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3
  • 14
    • 0026701936 scopus 로고
    • Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethylyluracil
    • Porter DJT, Chestnut WG, Merrill BM, et al: Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethylyluracil. J Biol Chem 267:5236-5242, 1992
    • (1992) J Biol Chem , vol.267 , pp. 5236-5242
    • Porter, D.J.T.1    Chestnut, W.G.2    Merrill, B.M.3
  • 15
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • Baker SD, Khor SP, Adjei AA, et al: Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 14:3085-3096, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.D.1    Khor, S.P.2    Adjei, A.A.3
  • 16
    • 0031900670 scopus 로고    scopus 로고
    • Phase I clinical and pharmacological study of eniluracil plus fluorouracil in patients with advanced cancer
    • Schilsky RL, Hohneker J, Ratain MJ, et al: Phase I clinical and pharmacological study of eniluracil plus fluorouracil in patients with advanced cancer. J Clin Oncol 16:1450-1457, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 1450-1457
    • Schilsky, R.L.1    Hohneker, J.2    Ratain, M.J.3
  • 17
    • 0027135995 scopus 로고
    • 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
    • Spector T, Harrington JA, Parker DJ: 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem Pharmacol 46:2243-2248, 1993
    • (1993) Biochem Pharmacol , vol.46 , pp. 2243-2248
    • Spector, T.1    Harrington, J.A.2    Parker, D.J.3
  • 18
    • 0029758307 scopus 로고    scopus 로고
    • Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity
    • McLeod HL, Keith WN: Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity. Br J Cancer 74:508-512, 1996
    • (1996) Br J Cancer , vol.74 , pp. 508-512
    • McLeod, H.L.1    Keith, W.N.2
  • 19
    • 0027462113 scopus 로고
    • Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation
    • van Gennip AH, Busch S, Elzinga L, et al: Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation. Clin Chem 39:380-385, 1993
    • (1993) Clin Chem , vol.39 , pp. 380-385
    • Van Gennip, A.H.1    Busch, S.2    Elzinga, L.3
  • 20
    • 0025990479 scopus 로고
    • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome
    • Harris BE, Carpenter JT, Diasio RB: Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome. Cancer 68:499-501, 1991
    • (1991) Cancer , vol.68 , pp. 499-501
    • Harris, B.E.1    Carpenter, J.T.2    Diasio, R.B.3
  • 21
    • 0029973215 scopus 로고    scopus 로고
    • Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
    • Wei X, McLeod HL, McMurrough J, et al: Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 98:610-615, 1996
    • (1996) J Clin Invest , vol.98 , pp. 610-615
    • Wei, X.1    McLeod, H.L.2    McMurrough, J.3
  • 22
    • 0028357629 scopus 로고
    • Relationship between fluorouracil systemic exposure and tumor response and patient survival
    • Milano G, Etienne MC, Renee N, et al: Relationship between fluorouracil systemic exposure and tumor response and patient survival. J Clin Oncol 12:1291-1295, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1291-1295
    • Milano, G.1    Etienne, M.C.2    Renee, N.3
  • 23
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
    • Beck A, Etienne MC, Cheradame S, et al: A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur J Cancer 30:1517-1522, 1994
    • (1994) Eur J Cancer , vol.30 , pp. 1517-1522
    • Beck, A.1    Etienne, M.C.2    Cheradame, S.3
  • 24
    • 0026045814 scopus 로고
    • A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa
    • Peters GJ, van Groeningen CJ, Laurensse EJ, et al: A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer 68:1903-1909, 1991
    • (1991) Cancer , vol.68 , pp. 1903-1909
    • Peters, G.J.1    Van Groeningen, C.J.2    Laurensse, E.J.3
  • 25
    • 0025351196 scopus 로고
    • Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas
    • Maehara Y, Moriguchi S, Emi Y, et al: Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas. Cancer 66:156-161, 1990
    • (1990) Cancer , vol.66 , pp. 156-161
    • Maehara, Y.1    Moriguchi, S.2    Emi, Y.3
  • 26
    • 0000419698 scopus 로고    scopus 로고
    • A phase II open-label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776c85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC)
    • abstr 1083
    • Mani S, Beck T, Chevlen E, et al: A phase II open-label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC). Proc Am Soc Clin Oncol 17:281a, 1998 (abstr 1083)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Mani, S.1    Beck, T.2    Chevlen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.