S731 in the transactivation domain modulates STAT5b activity

Biochemical and Biophysical Research Communications

Volumn 362, Issue 4, 2007, Pages 1026-1030

  Weaver, Amanda M ^a   Silva, Corinne M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Breast cancer; Serine phosphorylation; STAT5b; Tyrosine phosphorylation

Indexed keywords

CYTOKINE; GROWTH FACTOR; SERINE; STAT5B PROTEIN; TYROSINE;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DNA SYNTHESIS; DNA TRANSCRIPTION; FEMALE; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSACTIVATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CYSTEINE; GENE EXPRESSION REGULATION; HUMANS; PROTEIN STRUCTURE, TERTIARY; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TYROSINE;

EID: 34548557255     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.087     Document Type: Article

References (29)

1. Weaver A.M., and Silva C.M. Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. Molecular Endocrinology 20 (2006) 2392-2405
2. Yu H., and Jove R. The STATs of cancer-new molecular targets come of age. Nature Reviews Cancer 4 (2004) 97-105
3. Levy D., and Darnell Jr. J. STATs: transcriptional control and biological impact. Nature Reviews Molecular Cell Biology 3 (2002) 651-662
4. Silva C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 23 (2004) 8017-8023
5. Desrivieres S., Kunz C., Barash I., Vafaizadeh V., Borghouts C., and Groner B. The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. Journal of Mammary Gland Biology and Neoplasia 11 (2006) 75-87
6. Gouilleux F., Wakao H., Mundt M., and Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO Journal 13 (1994) 4361-4369
7. Gallego M.I., Binart N., Robinson G.W., Okagaki R., Coschigano K.T., Perry J., Kopchick J.J., Oka T., Kelly P.A., and Hennighausen L. Prolactin, growth hormone, and epidermal growth factor activate STAT5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Developmental Biology 229 (2001) 163-175
8. Kloth M.T., Laughlin K.K., Biscardi J.S., Boerner J.L., Parsons S.J., and Silva C.M. STAT5b, a mediator of synergism between c-Src and the epidermal growth factor receptor. Journal of Biological Chemistry 278 (2003) 1671-1679
9. Lin J.X., Mietz J., Modi W.S., John S., and Leonard W.J. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. Journal of Biological Chemistry 271 (1996) 10738-10744
10. Kloth M.T., Catling A.D., and Silva C.M. Novel activation of STAT5b in response to epidermal growth factor. Journal of Biological Chemistry 277 (2002) 8693-8701
11. Decker T., and Kovarik P. Serine phosphorylation of STATs. Oncogene 19 (2000) 2628-2637
12. Yamashita H., Nevalainen M.T., Xu J., LeBaron M., Wagner K., Erwin R.A., Harmon J.M., Hennighausen L., Kirken R.A., and Rui H. Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression. Molecular and Cellular Endocrinology 183 (2001) 151-163
13. Wartmann M., Cella N., Hofer P., Groner B., Liu X., Hennighausen L., and Hynes N. Lactogenic hormone activation of STAT5 and transcription of the β-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activation. Journal of Biological Chemistry 271 (1996) 31686-31863
14. Park S., Yamashita H., Rui H., and Waxman D.J. Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. Molecular Endocrinology 15 (2001) 2157-2171
15. Yamashita H., Xu J., Erwin R.A., Farrar W.L., Kirken R.A., and Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. Journal of Biological Chemistry 273 (1998) 30218-30244
16. Haq R., Halupa A., Beattie B.K., Mason J.M., Zanke B.W., and Barber D.L. Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases. Journal of Biological Chemistry 277 (2002) 17359-17366
17. Kirken R.A., Malabarba M.G., Xu J., Liu X., Farrar W.L., Hennighausen L., Larner A.C., Grimley P.M., and Rui H. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes. Journal of Biological Chemistry 272 (1997) 14098-14103
18. Uddin S., Lekmine F., Sassano A., Rui H., Fish E.N., and Platanias L.C. Role of Stat5 in type I interferon-signaling and transcriptional regulation. Biochemical and Biophysical Research Communications 308 (2003) 325-330
19. Buettner R., Mora L.B., and Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clinical Cancer Research 8 (2002) 945-954
20. Ahonen T.J., Xie J., LeBaron M., Zhu J., Nurmi M., Alanen K., Rui H., and Nevalainen M.T. Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. Journal of Biological Chemistry 278 (2003) 27287-27292
21. Xi S., Zhang Q., Dyer K.F., Lerner E.C., Smithgall T., Gooding W.E., Kamens J., and Grandis J.R. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. Journal of Biological Chemistry 278 (2003) 31574-31583
22. Xi S., Zhang Q., Gooding W.E., Smithgall T.E., and Grandis J.R. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Research 63 (2003) 6763-6771
23. A.M. Weaver, C.M. Silva, Signal transducer and activator of transcription 5b (STAT5b): A new target of breast tumor kinase, Breast Cancer Research (2007), Submitted for publication.
24. Kabotyanski E.B., Rosen J.M., and Kazansky A.V. Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. Journal of Biological Chemistry 278 (2003) 17218-17227
25. Olayioye M., Beuvink I., Horsch K., Daly J.M., and Hynes N. ErbB receptor-induced activation of Stat transcription factors is mediated by Src tyrsoine kinases. Journal of Biological Chemistry 274 (1999) 17209-17218
26. de Groot R., Raaijamkers J., Lammers J., Jove R., and Koenderman L. STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. Blood 94 (1999) 1108-1112
27. Friedrichsen B.N., Galsgaard E.D., Nielsen J.H., and Moldrup A. Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5). Molecular Endocrinology 15 (2001) 136-148
28. Gebert C.A., Park S., and Waxman D.J. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Molecular Endocrinology 11 (1997) 400-414
29. Smit L.S., Vanderkuur J.A., Stimage A., Han Y., Luo G., Yu-Lee L., Schwartz J., and Carter-Su C. Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B. Endocrinology 138 (1997) 3426-3434