Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression

Molecular and Cellular Endocrinology

Volumn 183, Issue 1-2, 2001, Pages 151-163

  Yamashita, Hiroko ^a   Nevalainen, Marja T ^a   Xu, Jun ^a   LeBaron, Matthew J ^a   Wagner, Kay Uwe ^b   Erwin, Rebecca A ^d   Harmon, Jeffrey M ^a   Hennighausen, Lothar ^c   Kirken, Robert A ^d   Rui, Hallgeir ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NEBRASKA MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

casein promoter; Glucocorticoid receptors; Mouse mammary gland; Prolactin; Stat5 transcriptional regulation

Indexed keywords

BETA CASEIN; GLUCOCORTICOID RECEPTOR; PROLACTIN; SERINE; STAT5 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CASEINS; CATTLE; CELL LINE; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; MILK PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOSERINE; PREGNANCY; PROLACTIN; RECEPTORS, GLUCOCORTICOID; SEQUENCE ALIGNMENT; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0035950441     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00546-9     Document Type: Article

References (35)

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2. Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells in long-term tissue culture
3. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
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15. Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A
16. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes
17. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase
18. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
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21. Stat5a is mandatory for adult mammary gland development and lactogenesis
22. Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype
23. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
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26. Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
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31. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
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34. Requirement of serine phosphorylation for formation of STAT-promoter complexes
35. Ser727-dependent recruitment of MCM5 by Statl alpha in IFN-gamma-induced transcriptional activation