Activation of T cells by cross-linking Qa-2, the Ped gene product, requires fyn

American Journal of Reproductive Immunology

Volumn 58, Issue 4, 2007, Pages 315-324

  De Fazio, Sally R ^a   Warner, Carol M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Akt; Fyn; Ped gene; Phosphatidylinosityl 3 kinase (PI 3 kinase); Qa 2; Signaling; T cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN ANTIBODY; PROTEIN KINASE B; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; QA 2 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; EMBRYO; FEMALE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANDROSTADIENES; ANIMALS; ANTIBODIES; BLASTOCYST; CELL PROLIFERATION; CELLS, CULTURED; CHROMONES; CROSS-LINKING REAGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOGLOBULINS; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; NUCLEOSIDES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-FYN; PYRIDAZINES; PYRIMIDINES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 34548528764     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00503.x     Document Type: Article

References (46)

1. Warner CM, Brenner CA: Genetic regulation of preimplantation embryo survival. Curr Top Dev Biol 2001; 52: 151-192.
2. Warner CM, Newmark J, Comiskey M, De Fazio SR, O'malley DM, Rajadhyaksha M, Townsend DJ, McKnight S, Roysam B, Dwyer PJ, Dimarzio CA: Genetics and imaging to assess oocyte and preimplantation embryo health. Reprod Fertil Dev 2004; 16: 729-741.
3. Warner CM: Immunological aspects of embryo development. In Human Embryo Evaluation & Selection, K Elder, J Cohen, PA Lemos (eds). London, UK, Informa Healthcare, 2007 (in press).
4. Comiskey M, Goldstein CY, De Fazio SR, Mammolenti M, Newmark JA, Warner CM: Evidence that HLA-G is the functional homolog of mouse Qa-2, the Ped gene product. Hum Immunol 2003; 64: 999-1004.
5. Comiskey M, Warner CM: HLA-G is found in lipid rafts and can act as a signaling molecule. Hum Immunol 2007; 68: 1-11.
6. Hunt JS, Langat DK, McIntire RH, Morales PJ: The role of HLA-G in human pregnancy. Reprod Biol Endocrinol 2006; 4 (Suppl 1): S10.
7. He X, Tabaczewski P, Ho J, Stroynowski I, Garcia KC: Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation. Structure 2001; 9: 1213-1224.
8. Tewarson S, Zaleska-Rutczynska Z, Figueroa F, Klein J: Polymorphism of Qa and Tla loci of the mouse. Tissue Antigens 1983; 22: 204-212.
9. Stiernberg J, Low MG, Flaherty L, Kincade PW: Removal of lymphocyte surface molecules with phosphatidylinositol- specific phospholipase C: effects on mitogen responses and evidence that ThB and certain Qa antigens are membrane-anchored via phosphatidylinositol. J Immunol 1987; 138: 3877-3884.
10. Suzuki K, Sheetz MP: Binding of cross-linked glycosylphosphatidylinositol-anchored proteins to discrete actin-associated sites and cholesterol-dependent domains. Biophys J 2001; 81: 2181-2189.
11. Warner CM, Gollnick SO, Flaherty L, Goldbard SB: Analysis of Qa-2 antigen expression by preimplantation mouse embryos possible relationship to the preimplantation-embryo-development (Ped) gene product. Biol Reprod 1987; 36: 611-616.
12. Ungchusri T, Chiang EY, Brown G, Chen M, Tabaczewski P, Timares L, Stroynowski I: Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells. Immunogenetics 2001; 53: 455-467.
13. Tian H, Imani F, Soloski MJ: Physical and molecular genetic analysis of Qa-2 antigen expression: Multiple factors controlling cell surface levels. Mol Immunol 1991; 28: 845-854.
14. Chiang EY, Henson M, Stroynowski I: The nonclassical major histocompatibility complex molecule Qa-2 protects tumor cells from NK cell- and lymphokine-activated killer cell-mediated cytolysis. J Immunol 2002; 168: 2200-2211.
15. Chiang EY, Stroynowski I: Protective immunity against disparate tumors is mediated by a nonpolymorphic MHC class I molecule. J Immunol 2005; 174: 5367-5374.
16. Das G, Gould DS, Augustine MM, Fragoso G, Sciutto E, Stroynowski I, Van Kaer L, Schust DJ, Ploegh H, Janeway CA: Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. J Exp Med 2000; 192: 1521-1528.
17. Poussier P, Ning T, Banerjee D, Julius M: A unique subset of self-specific intraintestinal T cells maintains gut integrity. J Exp Med 2002; 195: 1491-1497.
18. Hahn AB, Soloski MJ: Anti-Qa-2-induced T cell activation. The parameters of activation, the definition of mitogenic and nonmitogenic antibodies and the differential effects on CD4+ vs. CD8+ T cells. J Immunol 1989; 143: 407-413.
19. Robinson PJ, Millrain M, Antoniou J, Simpson E, Mellor AL: A glycophospholipid anchor is required for Qa-2-mediated T cell activation. Nature 1989; 342: 85-87.
20. Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B: The influence of the src-family kinases Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev 2003; 191: 107-118.
21. Kane LP, Weiss A: The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev 2003; 192: 7-20.
22. Stein PL, Lee HM, Rich S, Soriano P: Pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 1992; 70: 741-750.
23. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA: Discovery of a novel potent and Src family- selective tyrosine kinase inhibitor Study of Lck- and FynT-dependent T cell activation. J Biol Chem 1996; 27: 695-701.
24. Arcaro A, Wymann MP: Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 1993; 296: 297-301.
25. Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ: Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004; 64: 4394-4399.
26. Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994; 269: 5241-5248.
27. Heeg K, Reimann J, Kabelitz D, Hardt C, Wagner H: A rapid colorimetric assay for the determination of IL-2-producing helper T cell frequencies. J Immunol Methods 1985; 77: 237-246.
28. Lysechko TL, Ostergaard HL: Differential Src family kinase activity requirements for CD3 zeta phosphorylation/ZAP70 recruitment and CD3 epsilon phosphorylation. J Immunol 2005; 174: 7807-7814.
29. Heerklotz H: Triton promotes domain formation in lipid raft mixtures. Biophys J 2002; 83: 2693-2701.
30. Cook RG, Leone B, Leone JW, Widacki S, Zavell PJ: Characterization of T cell proliferative responses induced by anti-Qa-2 monoclonal antibodies. Cell Immunol 1992; 144: 367-381.
31. Filipp R, Julius M: Lipid rafts: resolution of the "fyn problem"? Mol Immunol 2004; 41: 645-656.
32. Stefanova I, Horejsi V, Ansotegui IJ, Knapp W, Stockinger H: GPI- anchored cell- surface molecules complexed to protein tyrosine kinases. Science 1991; 254: 1016-1019.
33. Shenoy-Scaria AM, Kwong J, Fujita T, Olszowy MW, Shaw AS, Lublin DM: Signal transduction through decay accelerating factor. Interaction of glycosyl- phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn. J Immunol 1992; 149: 3535-3541.
34. Lichtenberg D, Goni FM, Heerklotz H: Detergent- resistant membranes should not be identified with membrane rafts. Trends Biochem Sci 2005; 30: 430-436.
35. JacobsoA K, Mouritsen OG, Anderson RG: Lipid rafts: at a crossroad between cell biology and physics. Nat Cell Biol 2007; 9: 7-14.
36. Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R: Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol 2006; 26: 8655-8665.
37. Hahn AB, Tian H, Wiegand G, Soloski MJ: Signals delivered via the Qa-2 molecule can synergize with limiting anti-CD3-induced signals to cause T lymphocyte activation. Immunol Invest 1992; 21: 203-217.
38. Karnitz LM, Sutor SL, Abraham RT: The Src family kinase Fyn regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J Exp Med 1994; 179: 1799-1808.
39. Meng L, Luo J, Li C, Kinsey WH: Role of Src homology 2 domain-mediated PTK signaling in mouse zygotic development. Reproduction 2006; 132: 413-421.
40. Lu DP, Chandrakanthan V, Cahana A, Ishii S, O'Neill C: Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. J Cell Sci 2004; 117: 1567-1576.
41. Bi L, Okabe I, Bernard D, Nussbaum R: Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome 2002; 13: 169-172.
42. Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC: Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol 2005; 25: 2593-2606.
43. Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK, Moley KH: The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev Biol 2005; 284: 377-386.
44. Purnell ET, Warner CM, Kort HI, Mitchell-Leef D, Elsner CW, Shapiro DB, Massey JB, Roudebush WE: Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels. J Assist Reprod Genet 2006; 23: 269-273.
45. Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI: Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J 1994; 303: 749-753.
46. Song G, Ouyang G, Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9: 59-71.