Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development

Journal of Cell Science

Volumn 117, Issue 8, 2004, Pages 1567-1576

  Lu, D P ^a   Chandrakanthan, V ^a   Cahana, A ^a   Ishii, S ^b   O'Neill, Chris ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF TOKYO   (Japan)

^c ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Calcium signalling; PAF; PAF receptor; Phosphatidylinositol 3 kinase; Preimplantation embryo

Indexed keywords

1 O ALKYLGLYCERO 3 PHOSPHORYLCHOLINE; 2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM; MEMBRANE RECEPTOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; WORTMANNIN;

ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; CATALYSIS; CELL CYCLE; CELL NUCLEUS; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO GROWTH; ENZYME INHIBITION; ENZYME SUBUNIT; FEMALE; GENOTYPE; IN VITRO STUDY; INTERMETHOD COMPARISON; MALE; MORULA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL; ZYGOTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; BLASTOCYST; CALCIUM SIGNALING; CHROMONES; CULTURE MEDIA; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; ENZYME INHIBITORS; FEMALE; MICE; MICE, KNOCKOUT; MORPHOLINES; MORULA; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; PREGNANCY; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; ZYGOTE;

ANIMALIA; MAMMALIA;

EID: 2342417682     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00991     Document Type: Article

References (46)

1. Bi, L., Okabe, L, Bernard, D. J. and Nussbaum, R. L. (2002). Early embryonic lethality in mice deficient in p110β catalytic subunit of PI 3-kinase. Mam. Gen. 13, 169-172.
2. Brison, D. R. and Schultz, R. M. (1997). Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor? Biol. Reprod. 56, 1088-1096.
3. Emerson, M., Travis, A. R., Bathgate, R., Stojanov, T., Cook, D. I., Harding, E., Lu, D. P. and O'Neill, C. (2000). Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor. J. Biol. Chem. 275, 21905-21913.
4. Exley G., Tang, C., McElhinny, A. S. and Warner, C. M. (1999). Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos. Biol. Reprod. 61, 231-239.
5. Grynkiewicz, G., Poenie, M. and Tsien, R. Y. (1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
6. Hardy, K. (1999). Apoptosis in the human embryo. Rev. Reprod. 4, 125-134.
7. Hardy, K. and Spanos, S. (2002). Growth factor expression and function in the human and mouse preimplantation embryo. J. Endocrinol. 172, 221-236.
8. Hiller, G. and Sundler, R. (2002). Regulation of phospholipase C-gamma 2 via phosphatidyl 3-kinase in macrophages. Cell. Signal. 14, 169-173.
9. Honda, Z., Ishii, S. and Shimizu, T. (2002). Platelet-activating factor. J. Biochem. 131, 773-779.
10. Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W. H., Kume, K., Fukuchi, Y., Ikuta, K. et al. (1998). Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187, 1779-1788.
11. Ishii, S. and Shimizu, T. (2000). Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39, 41-82.
12. Jurisicova, A., Latham, K. E., Casper, R. F. and Varmuza, S. L. (1998). Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol. Reprod. Dev. 51, 243-253.
13. Jurisicova, A., Varmuza, S. and Casper, R. F. (1996). Programmed cell death and human embryo fragmentation. Mol. Hum. Reprod. 2, 93-98.
14. Kane, M. T., Morgan, P. M. and Coonan, C. (1997). Peptide growth factors and preimplantation development. Hum. Reprod. Update 3, 137-157.
15. Kaye, P. L. (1997). Preimplantation growth factor physiology. Rev. Reprod. 2, 121-127.
16. Lane, M. and Gardner, D. K. (1992). Effect of incubation volume and embryo density on the development and viability of mouse embryos in vitro. Hum. Reprod. 7, 558-562.
17. Lawlor, M. A. and Alessi, D. R. (2001). PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114, 2903-2910.
18. Lu, D. P., Li, Y., Bathgate, R., Day, M. and O'Neill, C. (2003). Ligand-activated signal transduction in the 2-cell embryo. Biol. Reprod. 69, 106-116.
19. Marte, B. M. and Downward, J. (1997). PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22, 355-358.
20. Moley, K. H., Chi, M. M.-Y., Knudson, C. M., Korsmeyer, S. J. and Mueckler, M. M. (1998). Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nature Med. 4, 1421-1424.
21. O'Neill, C. (1985a). Examination of the causes of early pregnancy associated thrombocytopenia in mice. J. Reprod. Fertil. 73, 567-577.
22. O'Neill, C. (1985b). Partial characterisation of the embryo-derived platelet activating factor in mice. J. Reprod. Fertil. 75, 375-380.
23. O'Neill, C. (1997). Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro. Biol. Reprod. 56, 229-237.
24. O'Neill, C. (1998). Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. Biol. Reprod. 58, 1303-1309.
25. O'Neill, C., Gidley-Baird, A. A., Pike, I. L. and Saunders, D. M. (1987). Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos. Fertil. Steril. 47, 969-975.
26. O'Neill, C., Ryan, J. P., Collier, M., Saunders, D. M., Ammit, A. J. and Pike, I. L. (1989). Supplementation of IVF culture media with platelet activating factor (PAF) increased the pregnancy rate following embryo transfer. Lancet 2, 769-772.
27. Paria, B. C. and Dey, S. K. (1990). Preimplantation embryo development in vitro: Cooperative interactions among embryos and the role of growth factors. Proc. Natl. Acad. Sci. USA 87, 4756-4760.
28. Powis, G., Bonjouklian, R., Berggren, M. M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J. and Grindey, G. (1994). Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Can. Res. 54, 2419-2423.
29. Quignard, J.-F., Mironneau, J., Carricaburu, V., Fournier, B., Babich, A., Nurnberg, B., Mironneau, C. and Macrez, N. (2001). Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes. J. Biol. Chem. 276, 32545-32551.
30. Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S. R., Ishizaki, Y. and Jacobsen, M. D. (1994). Programmed cell death and the control of cell survival. Philos. Trans. R. Soc. Lond. B Biol. Sci. 345, 265-268.
31. Roberts, C., O'Neill, C. and Wright, L. (1993). Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos. Reprod. Fertil. Dev. 5, 271-279.
32. Roudebush, W. E., Duralia, D. R. and Butler, W. J. (1996). Effect of platelet-activating factor (PAF) on preimplantation mouse B6D2F1/J embryo formation. Am. J. Reprod. Immunol. 35, 272-276.
33. Roudebush, W. E., LaMarche, M. D., Levine, A. S., Jiang, H. and Butler, W. J. (1997). Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. Biol. Reprod. 57, 575-579.
34. Roudebush, W. E., Mathur, S. and Butler, W. J. (1994). Anti-platelet activating factor (PAF) antibody inhibits CFW mouse preimplantation embryo development. J. Assist. Reprod. Genet. 11, 414-418.
35. Ryan, J. P., Spinks, N. R., O'Neill, C., Ammit, A. J. and Wales, R. G. (1989). Platelet activating factor (PAF) production by mouse embryos in-vitro and its effects on embryonic metabolism. J. Cell. Biochem. 40, 387-395.
36. Ryan, J. P., Spinks, N. R., O'Neill, C. and Wales, R. G. (1990). Implantation potential and fetal viability of mouse embryos cultured in media supplemented with platelet activating factor. J. Reprod. Fertil. 89, 309-315.
37. Salahuddin, S., Ookutsu, S., Goto, K., Nakanishi, Y. and Nagata, Y. (1995). Effects of embryo density and co-culture of unfertilized oocytes on embryonic development of in-vitro fertilized mouse embryos. Hum. Reprod. 10, 2382-2385.
38. Sawyer, D. B. and Anderson, O. S. (1989). Platelet-activating factor is a general membrane perturbant. Biochim. Biophys. Acta 987, 129-132.
39. Spinks, N. R. and O'Neill, C. (1988). Antagonists of embryo-derived platelet activating factor prevent implantation of mouse embryos. J. Reprod. Fertil. 84, 89-98.
40. Spinks, N. R., Ryan, J. P. and O'Neill, C. (1990). Antagonists of embryo-derived platelet activating factor act by inhibiting the ability of the mouse embryo to implant. J. Reprod. Fertil. 88, 241-248.
41. Stoddart, N. R., Wild, A. E. and Fleming, T. P. (1996). Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos. J. Reprod. Fertil. 108, 47-53.
42. Stojanov, T. and O'Neill, C. (1999). Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilisation and culure in vitro. Biol. Reprod. 60, 674-682.
43. Vereecken, A., Delbeke, L., Angle, M., Gielis, M., Gerris, J., Johnston, J. and Buytaert, P. (1990). Embryo-derived platelet activating factor, a marker of embryo quality and viability following ovarian stimulation for in vitro fertilisation. J. In Vitro Fert. Embryo Transf. 7, 321-326.
44. Weil, M., Jacobson, M. D., Coles, H. S. R., Davies, T. J., Gardner, R. L., Raff, K. D. and Raff, M. C. (1996). Constitutive expression of the machinery for programmed cell death. J. Cell Biol. 133, 1053-1059.
45. Whitten, W. K. and Biggers, J. D. (1968). Complete development in vitro of the pre-implantation stages of the mouse in a simple chemically defined medium. J. Reprod. Fertil. 17, 399-401.
46. Wu, C., Stojanov, T., Chami, O., Ishii, S., Shimizu, T., Li, A. and O'Neill, C. (2001). Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J. Biol. Chem. 276, 26962-26968.