Differential Src family kinase activity requirements for CD3ζ phosphorylation/ZAP70 recruitment and CD3ε phosphorylation

Journal of Immunology

Volumn 174, Issue 12, 2005, Pages 7807-7814

  Lysechko, Tara L ^a   Ostergaard, Hanne L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CD3 ANTIGEN; CD3 EPSILON ANTIGEN; CD3 XI ANTIGEN; PROTEIN KINASE INHIBITOR; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CYTOLYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 20444362420     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.12.7807     Document Type: Article

References (38)

1. Baniyash, M., P. Garcia-Morales, E. Luong, L. E. Samelson, and R. D. Klausner. 1988. The T cell antigen receptor ζ chain is tyrosine phosphorylated upon activation. J. Biol. Chem. 263: 18225-18230.
2. Iwashima, M., B. A. Irving, N. S. van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263: 1136-1139.
3. van Oers, N. S., N. Killeen, and A. Weiss. 1996. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183: 1053-1062.
4. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76: 263-274.
5. Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71: 649-662.
6. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells. J. Biol. Chem. 268: 19797-19801.
7. Hatada, M. H., X. Lu, E. R. Laird, J. Green, J. P. Morgenstern, M. Lou, C. S. Marr, T. B. Phillips, M. K. Ram, K. Theriault, et al. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377: 32-38.
8. Chan, A. C., M. Dalton, R. Johnson, G. H. Kong, T. Wang, R. Thoma, and T. Kurosaki. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14: 2499-2508.
9. Wange, R. L., R. Guitian, N. Isakov, J. D. Watts, R. Aebersold, and L. E. Samelson. 1995. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270: 18730-18733.
10. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92.
11. Tamura, G. S., M. O. Dailey, W. M. Gallatin, M. S. McGrath, I. L. Weissman, and E. A. Pillemer. 1984. Isolation of molecules recognized by monoclonal antibodies and antisera: the solid phase immunoisolation technique. Anal. Biochem. 136: 458-464.
12. Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271: 695-701.
13. Blakely, A., K. Gorman, H. Ostergaard, K. Svoboda, C. C. Liu, J. D. Young, and W. R. Clark. 1987. Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity. J. Exp. Med. 166: 1070-1083.
14. Berg, N. N., and H. L. Ostergaard. 1995. Characterization of intercellular adhesion molecule-1 (ICAM-1)-augmented degranulation by cytotoxic T cells: ICAM-1 and anti-CD3 must be co-localized for optimal adhesion and stimulation. J. Immunol. 155: 1694-1702.
15. Ostergaard, H. L., O. Lou, C. W. Arendt, and N. N. Berg. 1998. Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells. J. Biol. Chem. 273: 5692-5696.
16. Rozdzial, M. M., R. T. Kubo, S. L. Turner, and T. H. Finkel. 1994. Developmental regulation of the TCR ζ-chain: differential expression and tyrosine phosphorylation of the TCR ζ-chain in resting immature and mature T lymphocytes. J. Immunol. 153: 1563-1580.
17. lck-associated proteins in T cells. J. Immunol. 155: 5095-5103.
18. Pitcher, L. A., J. A. Young, M. A. Mathis, P. C. Wrage, B. Bartok, and N. S. van Oers. 2003. The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR ζ subunits. Immunol. Rev. 191: 47-61.
19. Moran, M., and M. C. Miceli. 1998. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity 9: 787-796.
20. Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70: 585-593.
21. Harder, T., and M. Kuhn. 2000. Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. J. Cell Biol. 151: 199-208.
22. Berg, N. N., L. G. Puente, W. Dawicki, and H. L. Ostergaard. 1998. Sustained TCR signaling is required for mitogen-activated protein kinase activation and degranulation by cytotoxic T lymphocytes. J. Immunol. 161: 2919-2924.
23. Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395: 82-86.
24. Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285: 221-227.
25. Lee, K. H., A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen, and A. S. Shaw. 2002. T cell receptor signaling precedes immunological synapse formation. Science 295: 1539-1542.
26. Freiberg, B. A., H. Kupfer, W. Maslanik, J. Delli, J. Kappler, D. M. Zaller, and A. Kupfer. 2002. Staging and resetting T cell activation in SMACs. Nat. Immunol. 3: 911-917.
27. Denny, M. F., B. Patai, and D. B. Straus. 2000. Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn. Mol. Cell. Biol. 20: 1426-1435.
28. Caplan, S., S. Zeliger, L. Wang, and M. Baniyash. 1995. Cell-surface-expressed T-cell antigen-receptor ζ chain is associated with the cytoskeleton. Proc. Natl. Acad. Sci. USA 92: 4768-4772.
29. Rozdzial, M. M., B. Malissen, and T. H. Finkel. 1995. Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3: 623-633.
30. Caplan, S., and M. Baniyash. 1996. Normal T cells express two T cell antigen receptor populations, one of which is linked to the cytoskeleton via ζ chain and displays a unique activation-dependent phosphorylation pattern. J. Biol. Chem. 271: 20705-20712.
31. lck form. Eur. J. Immunol. 31: 580-589.
32. van Oers, N. S., W. Tao, J. D. Watts, P. Johnson, R. Aebersold, and H. S. Teh. 1993. Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) ζ subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR ζ. Mol. Cell. Biol. 13: 5771-5780.
33. van Oers, N. S., N. Killeen, and A. Weiss. 1994. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1: 675-685.
34. van Oers, N. S., B. Tohlen, B. Malissen, C. R. Moomaw, S. Afendis, and C. A. Slaughter. 2000. The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations. Nat. Immunol. 1: 322-328.
35. Isakov, N., R. L. Wange, W. H. Burgess, J. D. Watts, R. Aebersold, and L. E. Samelson, 1995. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J. Exp. Med. 181: 375-380.
36. lck: differential regulation by TcR cross-linking. J. Biol. Chem. 271: 10054-10059.
37. Straus, D. B., A, C. Chan, B. Patai, and A. Weiss. 1996. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271: 9976-9981.
38. Pitcher, L. A., and N. S. van Oers. 2003. T-cell receptor signal transmission: who gives an ITAM? Trends Immunol. 24: 554-560.