Evaluation of neuroprotective and anti-fatigue effects of sildenafil

Life Sciences

Volumn 81, Issue 12, 2007, Pages 988-992

  Uthayathas, Subramaniam ^a,b   Karuppagounder, Senthilkumar S ^a   Tamer, Sibel Ilbasmis ^c   Parameshwaran, Kodeeswaran ^a   Degim, Tuncer ^c   Suppiramaniam, Vishnu ^a   Dhanasekaran, Muralikrishnan ^a  

^a AUBURN UNIVERSITY   (United States)

^b UNIVERSITY OF JAFFNA   (Sri Lanka)

^c GAZI UNIVERSITY   (Turkey)

Author keywords

6 OHDA; Dopamine; Fatigue; MPTP; Parkinson's disease; Sildenafil

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; NORADRENALIN; OXIDOPAMINE; SEROTONIN; SILDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; FATIGUE; FORCED SWIMMING TEST; MALE; MOUSE; NEUROCHEMISTRY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; RAT;

ANIMALS; FATIGUE; MALE; MICE; MICE, INBRED C57BL; MPTP POISONING; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SULFONES;

ANIMALIA; MUS; RATTUS;

EID: 34548526799     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.07.018     Document Type: Article

References (30)

1. Beal M.F., Matthews R.T., Tieleman A., and Shults C.W. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Research 783 1 (1998) 109-114
2. Chalimoniuk M., Lukacova N., Marsala J., and Langfort J. Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neuroscience 141 2 (2006) 1033-1046
3. Devan B.D., Bowker J.L., Duffy K.B., Bharati I.S., Jimenez M., Sierra-Mercado Jr. D., Nelson C.M., Spangler E.L., and Ingram D.K. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology (Berl) 183 4 (2006) 439-445
4. Dhanasekaran M., Uthayathas S., Karuppagounder S.S., Parameshwaran K., Suppiramaniam V., Ebadi M., and Brown-Borg H.M. Ebselen effects on MPTP-induced neurotoxicity. Brain Research 1118 1 (2006) 251-254
5. Dunnett S.B., and Bjorklund A. Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature 399 6738 Suppl (1999) A32-A39
6. Ferrari F., Ottani A., and Giuliani D. Influence of sildenafil on central dopamine-mediated behaviour in male rats. Life Sciences 70 13 (2002) 1501-1508
7. Heikkila R.E., Hess A., and Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 224 4656 (1984) 1451-1453
8. Kim K.M., Yu K.W., Kang D.H., and Suh H.J. Anti-stress and anti-fatigue effect of fermented rice bran. Phytotherapy Research 16 7 (2002) 700-702
9. Kroenke K., Wood D.R., Mangelsdorff A.D., Meier N.J., and Powell J.B. Chronic fatigue in primary care. Prevalence, patient characteristics, and outcome. JAMA 260 7 (1988) 929-934
10. Manyam B.V., Dhanasekaran M., and Hare T.A. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytotherapy Research 18 9 (2004) 706-712
11. Margel D., Cohen M., Livne P.M., and Pillar G. Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology 63 3 (2004) 545-549
12. Milani E., Nikfar S., Khorasani R., Zamani M.J., and Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comparative biochemistry and physiology. Toxicology & Pharmacology 140 2 (2005) 251-255
13. Mitra N., Mohanakumar K.P., and Ganguly D.K. Dissociation of serotoninergic and dopaminergic components in acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Research Bulletin 28 3 (1992) 355-364
14. Moser S.S., and Besler-Panos W. Pharmacotherapy for Parkinson's disease: current options, promising future therapies. JAAPA 19 8 (2006) 38-44
15. Muralikrishnan D., and Ebadi M. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Research 892 2 (2001) 241-248
16. Muralikrishnan D., Samantaray S., and Mohanakumar K.P. D-Deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse 50 1 (2003) 7-13
17. Porsolt R.D., Bertin A., and Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Archives internationales de pharmacodynamie et de thérapie 229 2 (1977) 327-336
18. Raffaele R., Vecchio I., Giammusso B., Morgia G., Brunetto M.B., and Rampello L. Efficacy and safety of fixed-dose oral sildenafil in the treatment of sexual dysfunction in depressed patients with idiopathic Parkinson's disease. European Urology 41 4 (2002) 382-386
19. Schober A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell and Tissue Research 318 1 (2004) 215-224
20. Sedelis M., Schwarting R.K., and Huston J.P. Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behavioural Brain Research 125 1-2 (2001) 109-125
21. Shimohama S., Sawada H., Kitamura Y., and Taniguchi T. Disease model: Parkinson's disease. Trends in Molecular Medicine 9 8 (2003) 360-365
22. Tharakan B., Dhanasekaran M., and Manyam B.V. Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus zeylanicus. Phytotherapy Research 19 8 (2005) 669-673
23. Tharakan B., Dhanasekaran M., Brown-Borg H.M., and Manyam B.V. Trichopus zeylanicuscombats fatigue without amphetamine-mimetic activity. Phytotherapy Research 20 3 (2006) 165-168
24. Thongsaard W., and Marsden C.A. A herbal medicine used in the treatment of addiction mimics the action of amphetamine on in vitro rat striatal dopamine release. Neuroscience Letters 329 2 (2002) 129-132
25. Ungerstedt U., Ljungberg T., and Steg G. Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons. Advances in Neurology 5 (1974) 421-426
26. Uthayathas S., Karuppagounder S.S., Thrash B.M., Parameshwaran K., Suppiramaniam V., and Dhanasekaran M. Versatile effects of sildenafil: recent pharmacological applications. Pharmacological Reports 59 2 (2007) 150-163
27. Wang L., Zhang Z.G., Zhang R.L., and Chopp M. Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone. Journal of Cerebral Blood Flow and Metabolism 25 9 (2005) 1150-1158
28. Xie Z., Adamowicz W.O., Eldred W.D., Jakowski A.B., Kleiman R.J., Morton D.G., Stephenson D.T., Strick C.A., Williams R.D., and Menniti F.S. Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase. Neuroscience 139 2 (2006) 597-607
29. Zhang R., Wang Y., Zhang L., Zhang Z., Tsang W., Lu M., Zhang L., and Chopp M. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33 11 (2002) 2675-2680
30. Zhang R.L., Zhang Z., Zhang L., Wang Y., Zhang C., and Chopp M. Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia. Journal of Neuroscience Research 83 7 (2006) 1213-1219