Structural dynamics in the gating ring of cyclic nucleotide-gated ion channels

Nature Structural and Molecular Biology

Volumn 14, Issue 9, 2007, Pages 854-860

  Taraska, Justin W ^a   Zagotta, William N ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE GATED CHANNEL 1; ION CHANNEL; N ETHYLMALEIMIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CHANNEL GATING; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUOROMETRY; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; ION CHANNEL GATING; MOLECULAR PROBES; NUCLEOTIDES; PROTEIN CONFORMATION;

EID: 34548499865     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb1281     Document Type: Article

References (37)

1. Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, USA, 2001).
2. Schreiber, M., Yuan, A. & Salkoff, L. Transplantable sites confer calcium sensitivity to BK channels. Nat. Neurosci. 2, 416-421 (1999).
3. Brauchi, S., Orta, G., Salazar, M., Rosenmann, E. & Latorre, R. A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. J. Neurosci. 26, 4835-4840 (2006).
4. Craven, K.B. & Zagotta, W.N. CNG and HCN channels: two peas, one pod. Annu. Rev. Physiol. 68, 375-401 (2006).
5. Zagotta, W.N. et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425, 200-205 (2003).
6. Selvin, P.R. Fluorescence resonance energy transfer. Methods Enzymol. 246, 300-334 (1995).
7. Vogel, S.S., Thaler, C. & Koushik, S.V. Fanciful FRET. Sci. STKE 2006, re2 (2006).
8. Lakowicz, J.R. Principles of Fluorescence Spectroscopy (Plenum, New York, 1999).
9. Zheng, J. & Zagotta, W.N. Gating rearrangements in cyclic nucleotide-gated channels revealed by patch-clamp fluorometry. Neuron 28, 369-374 (2000).
10. Zagotta, W.N. & Siegelbaum, S.A. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19, 235-263 (1996).
11. Craven, K.B. & Zagotta, W.N. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J. Gen. Physiol. 124, 663-677 (2004).
12. Johnson, J.P., Jr & Zagotta, W.N. Rotational movement during cyclic nucleotide-gated channel opening. Nature 412, 917-921 (2001).
13. Hua, L. & Gordon, S.E. Functional interactions between A′ helices in the C-linker of open CNG channels. J. Gen. Physiol. 125, 335-344 (2005).
14. Matulef, K., Flynn, G.E. & Zagotta, W.N. Molecular rearrangements in the ligand-binding domain of cyclic nucleotide-gated channels. Neuron 24, 443-452 (1999).
15. Chanda, B., Asamoah, O.K., Blunck, R., Roux, B. & Bezanilla, F. Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature 436, 852-856 (2005).
16. Islas, L.D. & Zagotta, W.N. Short-range molecular rearrangements in ion channels detected by tryptophan quenching of bimane fluorescence. J. Gen. Physiol. 128, 337-346 (2006).
17. Gordon, S.E., Varnum, M.D. & Zagotta, W.N. Direct interaction between amino- and carboxyl-terminal domains of cyclic nucleotide-gated channels. Neuron 19, 431-441 (1997).
18. Brown, R.L., Snow, S.D. & Haley, T.L. Movement of gating machinery during the activation of rod cyclic nucleotide-gated channels. Biophys. J. 75, 825-833 (1998).
19. Chanda, B. et al. A hybrid approach to measuring electrical activity in genetically specified neurons. Nat. Neurosci. 8, 1619-1626 (2005).
20. Fernandez, J.M., Taylor, R.E. & Bezanilla, F. Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J. Gen. Physiol. 82, 331-346 (1983).
21. Inouye, S. & Tsuji, F.I. Evidence for redox forms of the Aequorea green fluorescent protein. FEBS Lett. 351, 211-214 (1994).
22. Ostergaard, H., Henriksen, A., Hansen, F.G. & Winther, J.R. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein. EMBO J. 20, 5853-5862 (2001).
23. 2+-calmodulin modulation of cyclic nucleotide-gated channels. J. Neurosci. 23, 8167-8175 (2003).
24. Wainger, B.J., DeGennaro, M., Santoro, B., Siegelbaum, S.A. & Tibbs, G.R. Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805-810 (2001).
25. Vemana, S., Pandey, S. & Larsson, H.P. S4 movement in a mammalian HCN channel. J. Gen. Physiol. 123, 21-32 (2004).
26. + channels. Cell 126, 1161-1173 (2006).
27. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515-522 (2002).
28. Popovych, N., Sun, S., Ebright, R.H. & Kalodimos, C.G. Dynamically driven protein allostery. Nat. Struct. Mol. Biol. 13, 831-838 (2006).
29. Cordero-Morales, J.F. et al. Molecular determinants of gating at the potassium-channel selectivity filter. Nat. Struct. Mol. Biol. 13, 311-318 (2006).
30. Kaupp, U.B. et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342, 762-766 (1989).
31. Gordon, S.E. & Zagotta, W.N. A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14, 177-183 (1995).
32. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85-100 (1981).
33. Cha, A. & Bezanilla, F. Structural implications of fluorescence quenching in the Shaker K+ channel. J. Gen. Physiol. 112, 391-408 (1998).
34. Wolber, P.K. & Hudson, B.S. An analytic solution to the Forster energy transfer problem in two dimensions. Biophys. J. 28, 197-210 (1979).
35. Flynn, G.E. & Zagotta, W.N. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron 30, 689-698 (2001).
36. Guex, N. & Peitsch, M.C. SWISS-MODEL and the Swiss-Pdb Viewer: an environment for comparative protein modeling. Electrophoresis 18, 2714-2723 (1997).
37. + channel. Science 309, 897-903 (2005).