RGD-containing fibrillin-1 fragments upregulate matrix metalloproteinase expression in cell culture: A potential factor in the pathogenesis of the Marfan syndrome

Human Genetics

Volumn 116, Issue 1-2, 2005, Pages 51-61

  Booms, Patrick ^a   Pregla, Reinhard ^b   Ney, Andreas ^a   Barthel, Frank ^b   Reinhardt, Dieter P ^c   Pletschacher, Angelika ^a   Mundlos, Stefan ^a,d   Robinson, Peter N ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; FIBRILLIN 1; GELATINASE A; INTEGRIN; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; STROMELYSIN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; FIBROBLAST CULTURE; FRAGMENTATION REACTION; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MARFAN SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ENZYME INDUCTION; HUMANS; MARFAN SYNDROME; MATRIX METALLOPROTEINASES; MICROFILAMENT PROTEINS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; SEQUENCE ANALYSIS, PROTEIN;

EID: 11244352033     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-004-1194-7     Document Type: Article

References (47)

1. Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, Kielty CM (1999) Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem J 340:171-181
2. 3 integrins. J Biol Chem 278:34605-34616
3. Benbow U, Brinckerhoff CE (1997) The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol 15:519-526
4. 3 integrin. Arterioscler Thromb Vasc Biol 20:1467-1472
5. Booms P, Tiecke F, Rosenberg T, Hagemeier C, Robinson PN (2000) Differential effect of FBN1 mutations on in vitro proteolysis of recombinant fibrillin-1 fragments. Hum Genet 107:216-224
6. Borkakoti N (1998) Matrix metalloproteases: Variations on a theme. Prog Biophys Mol Biol 70:73-94
7. Brassart B, Fuchs P, Huet E, Alix AJP, Wallach J, Tamburro AM, Delacoux F, Haye B, Emonard H, Hornebeck W, Debelle L (2001) Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts. J Biol Chem 276:5222-5227
8. Dans MJ, Giancotti FG (1999) Signaling via integrins. In: Kreis T, Vale R (eds) Guidebook to the extracellular matrix, anchor, and adhesion proteins, 2nd edn. Oxford University Press, Oxford, pp 134-139
9. D'Arrigo C, Burl S, Withers AP, Dobson H, Black C, Boxer M (1998) TGF-beta1 binding protein-like modules of fibrillin-1 and -2 mediate integrin-dependent cell adhesion. Connect Tissue Res 37:29-51
10. Dietz HC, McIntosh I, Sakai LY, Corson GM, Chalberg SC, Pyeritz RE, Francomano CA (1993) Four novel FBN1 mutations: Significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome. Genomics 17:468-475
11. Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA (1996) Solution structure of a pair of calcium-binding epidermal growth factor-like domains: Implications for the Marfan syndrome and other genetic disorders. Cell 85:597-605
12. Fini ME, Cook JR, Mohan R, Brinckerhoff CE (1998) Regulation of matrix metalloproteinase gene expression. In: Parks WC, Mecham R (eds) Matrix metalloproteinases. Academic Press, San Diego, pp 299-356
13. Fleischer KJ, Nousari HC, Anhalt GJ, Stone CD, Laschinger JC (1997) Immunohistochemical abnormalities of fibrillin in cardiovascular tissues in Marfan's syndrome. Ann Thorac Surg 63:1012-1017
14. Forsyth CB, Pulai J, Loeser RF (2002) Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum 46:2368-2376
15. Fujimoto N, Mouri N, Iwata K, Ohuchi E, Okada Y, Hayakawa T (1993) A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies. Clin Chim Acta 221:91-103
16. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997) Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277:225-228
17. Hemler ME (1999) Integrins. In: Kreis T, Vale R (eds) Guidebook to the extracellular matrix, anchor, and adhesion proteins, 2nd edn. Oxford University Press, Oxford
18. Hering TM (1999) Regulation of chondrocyte gene expression. Front Biosci 4:D743-D761
19. Homandberg GA (1999) Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments. Front Biosci 4:D713-D730
20. Homandberg GA, Hui F, Wen C, Purple C, Bewsey K, Koepp H, Huch K, Harris A (1997) Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines. Biochem J 321):751-757
21. Hu B, Kapila YL, Buddhikot M, Shiga M, Kapila S (2000) Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: UPA contributes to activation of procollagenase-1. Matrix Biol 19:657-669
22. Jensen SA, Reinhardt DP, Gibson MA, Weiss AS (2001) Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. J Biol Chem 276:39661-39666
23. Khan KM, Falcone DJ (2000) Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1: Ser(2091) - Arg(2108) regulates macrophage degradative phenotype. J Biol Chem 275:4492-4498
24. Loeser RF, Forsyth CB, Samarel AM, Im HJ (2003) Fibronectin-fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 278:24577-24585
25. McGettrick AJ, Knott V, Willis A, Handford PA (2000) Molecular effects of calcium binding mutations in Marfan syndrome depend on domain context. Hum Mol Genet 9:1987-1994
26. Nagase H, Woessner JF Jr (1999) Matrix metalloproteinases. J Biol Chem 274:21491-21494
27. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC (2003) Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33:407-411
28. Obata K, Iwata K, Okada Y, Kohrin Y, Ohuchi E, Yoshida S, Shinmei M, Hayakawa T (1992) A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies. Clin Chim Acta 211:59-72
29. Parks WC, Sudbeck BD, Doyle GR, Saariahlo-Kere UK (1998) Matrix metalloproteases in tissue repair. In: Parks WC, Mecham R (eds) Matrix metalloproteases. Academic Press, San Diego, pp 263-297
30. Pereira L, D'Alessio M, Ramirez F, Lynch JR, Sykes B, Pangilinan T, Bonadio J (1993) Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome. Hum Mol Genet 2:1762
31. Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono R, Reinhardt DP, Sakai LY, Biery NJ, Bunton T, Dietz HC, Ramirez F (1997) Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet 17:218-222
32. Pereira L, Lee SY, Gayraud B, Andrikopoulos K, Shapiro SD, Bunton T, Biery NJ, Dietz HC, Sakai LY, Ramirez F (1999) Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci USA 96:3819-3823
33. Pfaff M, Reinhardt DP, Sakai LY, Timpl R (1996) Cell adhesion and integrin binding to recombinant human fibrillin-1. FEBS Lett 384:247-250
34. Pyeritz RE (2000) The Marfan syndrome. Annu Rev Med 51:481-510
35. Reinhardt DP, Keene DR, Corson GM, Poschl E, Bachinger HP, Gambee JE, Sakai LY (1996) Fibrillin-1: Organization in microfibrils and structural properties. J Mol Biol 258:104-116
36. Reinhardt DP, Ono RN, Sakai LY (1997) Calcium stabilizes fibrillin-1 against proteolytic degradation. J Biol Chem 272:1231-1236
37. Reinhardt DP, Ono RN, Notbohm H, Muller PK, Bachinger HP, Sakai LY (2000) Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis. A potential disease-causing mechanism in Marfan syndrome. J Biol Chem 275:12339-12345
38. Robinson PN, Godfrey M (2000) The molecular genetics of Marfan syndrome and related microfibrillopathies. J Med Genet 37:9-25
39. Sachdev NH, Di Girolamo N, McCluskey PJ, Jennings AV, McGuinness R, Wakefield D, Coroneo MT (2002) Lens dislocation in Marfan syndrome: potential role of matrix metalloproteinases in fibrillin degradation. Arch Ophthalmol 120:833-835
40. Saito S, Yamaji N, Yasunaga K, Saito T, Matsumoto S-i, Katoh M, Kobayashi S, Masuho Y (1999) The fibronectin extra domain A activates matrix metalloproteinase gene expression by an interleukin-1-dependent mechanism. J Biol Chem 274:30756-30763
41. Sakamoto H, Broekelmann T, Cheresh DA, Ramirez F, Rosenbloom J, Mecham RP (1996) Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem 271:4916-4922
42. Segura AM, Luna RE, Horiba K, Stetler-Stevenson WG, McAllister HA Jr, Willerson JT, Ferrans VJ (1998) Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome. Circulation 98 (19 Suppl): II331-II337; discussion II337-II338
43. Sternlicht MD, Werb Z (2001) How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17:463-516
44. Sudbeck BD, Pilcher BK, Welgus HG, Parks WC (1997) Induction and repression of collagenase-1 by keratinocytes is controlled by distinct components of different extracellular matrix compartments. J Biol Chem 272:22103-22110
45. Vu TH, Werb Z (1998) Gelatinase B: Structure, regulation, and function. In: Parks WC, Mecham R (eds) Matrix metalloproteinases. Academic Press, San Diego, pp 115-148
46. Yasuda T, Poole AR (2002) A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway. Arthritis Rheum 46:138-148
47. Zhang J, Fujimoto N, Iwata K, Sakai T, Okada Y, Hayakawa T (1993) A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies. Clin Chim Acta 219:1-14