Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

British Journal of Pharmacology

Volumn 150, Issue 8, 2007, Pages 1075-1083

  Chung, A W Y ^a,c   Au Yeung, K ^a   Cortes, S F ^b   Sandor, G G S ^c   Judge, D P ^d   Dietz, H C ^d   Van Breemen, C ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Akt, age related disease progression; Endothelium dependent relaxation; Marfan syndrome; Nitric oxide; Thoracic aorta

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRILLIN 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PROTEIN KINASE B;

ABDOMINAL AORTA; ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; GENE MUTATION; GROUPS BY AGE; HETEROZYGOSITY; ISOMETRICS; MARFAN SYNDROME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION; WESTERN BLOTTING;

EID: 34247280551     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707181     Document Type: Article

References (47)

1. Bank AJ, Kaiser DR, Rajala S, Cheng A (1999). In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. Circulation 100: 41-47.
2. Boutouyrie P, Bezie Y, Lacolley P, Challande P, Chamiot-Clerc P, Benetos A et al. (1997). In vivo/in vitro comparison of rat abdominal aorta wall viscosity. Influence of endothelial function. Arterioscler Thromb Vasc Biol 17: 1346-1355.
3. Bradley TJ, Potts JE, Potts MT, DeSouza AM, Sandor GG (2005). Echocardiographic Doppler assessment of the biophysical properties of the aorta in pediatric patients with the Marfan syndrome. Am J Cardiol 96: 1317-1321.
4. Castillo C, Reyes G, Escalante B, Lopez P, Castillo EF (1997). Endothelium-dependent vasodilatation in rat aorta is mainly mediated by nitric oxide. Proc West Pharmacol Soc 40: 39-40.
5. Ceravolo R, Maio R, Pujia A, Sciacqua A, Ventura G, Costa MC et al. (2003). Pulse pressure and endothelial dysfunction in never-treated hypertensive patients. J Am Coll Cardiol 41: 1753-1758.
6. Cocks TM, Angus JA, Campbell JH, Campbell GR (1985). Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture. J Cell Physiol 123: 310-320.
7. Davis EC (1994). Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta. J Cell Sci 107: 727-736.
8. Dietz HC, Cutting GR, Pyeritz RE, Maslen CL, Sakai LY, Corson GM et al (1991). Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature 352: 337-339.
9. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999). Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605.
10. Gerhard M, Roddy MA, Creager SJ, Creager MA (1996). Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27: 849-853.
11. Giusti B, Porciani MC, Brunelli T, Evangelisti L, Fedi S, Gensini GF et al. (2003). Phenotypic variability of cardiovascular manifestations in Marfan syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism. Eur Heart J 24: 2038-2045.
12. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK et al. (2006). Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312: 117-121.
13. Halloran BG, Davis VA, McManus BM, Lynch TG, Baxter BT (1995). Localization of aortic disease is associated with intrinsic differences in aortic structure. J Surg Res 59: 17-22.
14. Jeremy RW, Huang H, Hwa J, McCarron H, Hughes CF, Richards JG (1994). Relation between age, arterial distensibility, and aortic dilatation in the Marfan syndrome. Am J Cardiol 74: 369-373.
15. Jiang X, Yang F, Tan H, Liao D, Bryan Jr RM, Randhawa JK et al. (2005). Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol 25: 2515-2521.
16. Jondeau G, Muti C, Boileau C (2003). Aortic aneurysms excluding Marfan's syndrome. Arch Mal Coeur Vaiss 96: 1074-1080.
17. Judge DP, Biery NJ, Keene DR, Geubtner J, Myers L, Huso DL et al. (2004). Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J Clin Invest 114: 172-181.
18. Kielty CM, Wilson DG, Stuart G, Musumeci F, Jones CJ, Davies S et al. (1996). Fibrillin expression and deposition by vascular endothelial cells: implications for the Marfan syndrome. Circulation 94: I-350.
19. Kojda G, Hambrecht R (2005). Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc Res 67: 187-197.
20. Nakamura M, Itoh S, Makita S, Ohira A, Arakawa N, Hiramori K (2000). Peripheral resistance vessel dysfunction in Marfan syndrome. Am Heart J 139: 661-666.
21. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B et al. (2003). Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33: 407-411.
22. Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D et al. (2004). TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 114: 1586-1592.
23. + response in individual endothelial cells of the artery in situ. Am J Physiol 272: C1980-C1987.
24. Okon EB, Chung AW, Rauniyar P, Padilla E, Tejerina T, McManus BM et al. (2005). Compromised arterial function in human type 2 diabetic patients. Diabetes 54: 2415-2423.
25. Okon EB, Szado T, Laher I, McManus B, van Breemen C (2003). Augmented contractile response of vascular smooth muscle in a diabetic mouse model. J Vasc Res 40: 520-530.
26. Orsi AM, Stefanini MA, Crocci AJ, Simoes K, Ribeiro AA (2004). Some segmental features on the structure of the aortic wall of the dog. Anat Histol Embryol 33: 131-134.
27. Peng X, Haldar S, Deshpande S, Irani K, Kass DA (2003). Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension 41: 378-381.
28. Pereira L, Lee SY, Gayraud B, Andrikopoulos K, Shapiro SD, Bunton T et al. (1999). Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci USA 96: 3819-3823.
29. Pohl U, Holtz J, Busse R, Bassenge E (1986). Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8: 37-44.
30. Pyeritz RE (2000). The Marfan syndrome. Annu Rev Med 51: 481-510.
31. Ramsey MW, Goodfellow J, Jones CJ, Luddington LA, Lewis MJ, Henderson AH (1995). Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation 92: 3212-3219.
32. Rapoport RM, Draznin MB, Murad F (1983). Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306: 174-176.
33. Sandor GG, Hishitani T, Petty RE, Potts MT, Desouza A, Desouza E et al. (2003). A novel Doppler echocardiographic method of measuring the biophysical properties of the aorta in pediatric patients. J Am Soc Echocardiogr 16: 745-750.
34. Schwartz EA, Reaven E, Topper JN, Tsao PS (2005). Transforming growth factor-beta receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells. Biochem J 390: 199-206.
35. Sheremet'eva GF, Ivanova AG, Belov Iu V, Gens AP, Kocharian EZ (2004). A comparative study of the aortic wall in patients with Marfan's syndrome and Erdheim's disease. Angiol Sosud Khir 10: 22-29.
36. Smith AR, Visioli F, Frei B, Hagen TM (2006). Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell 5: 391-400.
37. Tao J, Jin YF, Yang Z, Wang LC, Gao XR, Lui L et al. (2004). Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement. Am J Hypertens 17: 654-659.
38. Ueda H, Moritoki H (1991). Possible association of decrease of ATP-induced vascular relaxation with reduction of cyclic GMP during aging. Arch Int Pharmacodyn Ther 310: 35-45.
39. Vitarelli A, Conde Y, Cimino E, D'Angeli I, D'Orazio S, Stellato S et al. (2006). Aortic wall mechanics in the Marfan syndrome assessed by transesophageal tissue Doppler echocardiography. Am J Cardiol 97: 571-577.
40. 2+ store in fresh endothelial cells and evidence for ryanodine receptors. Circ Res 77: 37-42.
41. Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR (2002). Nitric oxide regulates local arterial distensibility in vivo. Circulation 105: 213-217.
42. Wilson DG, Bellamy MF, Ramsey MW, Goodfellow J, Brownlee M, Davies S et al. (1999). Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. Circulation 99: 909-915.
43. Wolfgarten B, Kruger I, Gawenda M (2001). Rare manifestation of abdominal aortic aneurysm and popliteal aneurysm in a patient with Marfan's syndrome: a case report. Vasc Surg 35: 81-84.
44. Wolinsky H, Glagov S (1969). Comparison of abdominal and thoracic aortic medial structure in mammals. Deviation of man from the usual pattern. Circ Res 25: 677-686.
45. Wyatt AW, Steinert JR, Mann GE (2004). Modulation of the L-arginine/nitric oxide signalling pathway in vascular endothelial cells. Biochem Soc Symp 71: 143-156.
46. Yaginuma T, Avolio A, O'Rourke M, Nichols W, Morgan JJ, Roy P et al. (1986). Effect of glyceryl trinitrate on peripheral arteries alters left ventricular hydraulic load in man. Cardiovasc Res 20: 153-160.
47. Yin FC, Brin KP, Ting CT, Pyeritz RE (1989). Arterial hemodynamic indexes in Marfan's syndrome. Circulation 79: 854-862.