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5
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33744928374
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Selected recent examples: carbon-heteroatom bond formation: a K. L. Hull, W. Q. Anani, M.S. Sanford, J. Am. Chem. Soc. 2006, 128, 7134-7135;
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Selected recent examples: carbon-heteroatom bond formation: a) K. L. Hull, W. Q. Anani, M.S. Sanford, J. Am. Chem. Soc. 2006, 128, 7134-7135;
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6
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33750349079
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1368413685; carbon-carbon bond formation;
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b) J. M. Murphy, J. D. Lawrence, K. Kawamura, C. Incarvito, J.F. Hartwig, J. Am. Chem. Soc. 2006, 128, 1368413685; carbon-carbon bond formation;
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Murphy, J.M.1
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d) M. Lafrance, C. N. Rowley, T. K. Woo, K. Fagnou, J. Am. Chem. Soc. 2006, 128, 8754-8756;
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J. Am. Chem. Soc
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Lafrance, M.1
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33749509027
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e) X. Chen, C. E. Goodhue, J.-Q. Yu, J. Am. Chem. Soc. 2006, 128, 12634-12635;
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J. Am. Chem. Soc
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Chen, X.1
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R. Martinez, R. Chevalier, S. Darses, J.-P. Genêt, Angew. Chem. Int. Ed. 2006, 45, 82328235.
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f) R. Martinez, R. Chevalier, S. Darses, J.-P. Genêt, Angew. Chem. Int. Ed. 2006, 45, 82328235.
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0037134813
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Selected examples: a J. A. Johnson, N. Li, D. Sames, J. Am. Chem. Soc. 2002, 124, 6900-6903;
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Selected examples: a) J. A. Johnson, N. Li, D. Sames, J. Am. Chem. Soc. 2002, 124, 6900-6903;
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13
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33646466149
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c)R. M. Wilson, R. K. Thalji, R. G. Bergman, J.A. Ellman, Org. Lett. 2006, 8, 1745-1747.
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a) L. F. Tietze, Chem. Rev. 1996, 96, 115-136;
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Tietze, L.F.1
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Tetrahedron
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Poli, G.1
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33750977591
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c) K. C. Nicolaou, D. J. Edmonds, P. G. Bulger, Angew. Chem. Int. Ed. 2006, 45, 7134-7186.
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Nicolaou, K.C.1
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19
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33645927023
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Recent examples of palladium-catalyzed pure domino sequences involving a C-H activation step: a A. Kong, X. Han, X. Lu, Org. Lett. 2006, 8, 1339-1342;
-
Recent examples of palladium-catalyzed pure domino sequences involving a C-H activation step: a) A. Kong, X. Han, X. Lu, Org. Lett. 2006, 8, 1339-1342;
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20
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33748968334
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b) C.Bour, G. Blond, B. Salem, J. Suffert, Tetrahedron 2006, 62, 10567-10581;
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Tetrahedron
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Bour, C.1
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33747620070
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Furuta, T.1
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22
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33748928964
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K. Mitsudo, P. Thansandote, T. Wilhelm, B. Mariampillai, M. Lautens, Org. Lett. 2006, 8, 39393942;
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d) K. Mitsudo, P. Thansandote, T. Wilhelm, B. Mariampillai, M. Lautens, Org. Lett. 2006, 8, 39393942;
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24
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33750346700
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f) A. Pinto, L. Neuville, P. Retailleau, J. Zhu, Org. Lett. 2006, 8, 4927-4930;
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Pinto, A.1
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33644529707
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a) J.-P. Leclerc, M. André, K. Fagnou, J. Org. Chem. 2006, 71, 1711-1714;
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Leclerc, J.-P.1
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28
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33751262964
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For a recent related example of 5-endo-trig Heck cyclization, see: P. Vital, P.-O. Norrby, D. Tanner, Synlett 2006,18, 3140-3144.
-
For a recent related example of 5-endo-trig Heck cyclization, see: P. Vital, P.-O. Norrby, D. Tanner, Synlett 2006,18, 3140-3144.
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29
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0344132082
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S. Bräse, Synlett 1999, 10, 1654-1656.
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G. Poli, G. Giambastiani, J. Org. Chem. 2002, 67, 94569459.
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G. Poli, G. Giambastiani, J. Org. Chem. 2002, 67, 94569459.
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31
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0033549049
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JohnPhos: 2-(di-ferf-butylphosphino)biphenyl, see: A. Aranyos, D. W. Old, A. Kiyomori, J. P. Wolfe, J. P. Sadighi, S. L. Buchwald, J. Am. Chem. Soc. 1999, 121, 4369-4378.
-
JohnPhos: 2-(di-ferf-butylphosphino)biphenyl, see: A. Aranyos, D. W. Old, A. Kiyomori, J. P. Wolfe, J. P. Sadighi, S. L. Buchwald, J. Am. Chem. Soc. 1999, 121, 4369-4378.
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-
-
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32
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34548406792
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On the contrary, starting from lb, the final product is formed earlier in the process and is consequently more prone to decomposition. This may partly account for the modest yields observed with this substrate when the 4-membered ring is favored.
-
On the contrary, starting from lb, the final product is formed earlier in the process and is consequently more prone to decomposition. This may partly account for the modest yields observed with this substrate when the 4-membered ring is favored.
-
-
-
-
33
-
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0037121577
-
-
Other examples: S. Caddick, W. Kofie, Tetrahedron Lett. 2002, 43, 9347-9350.
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Other examples: S. Caddick, W. Kofie, Tetrahedron Lett. 2002, 43, 9347-9350.
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-
-
-
34
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34548393931
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3) - H activation/Heck cyclization 2 step process, only moderate overall yields were observed most probably due to partial decomposition of the heat-sensitive exo-methylenebenzocyclobutene moiety during the Heck steps, that lowered the efficiency of these usually high-yielding reactions and, consequently, of the overall 3-step process.
-
3) - H activation/Heck cyclization 2 step process, only moderate overall yields were observed most probably due to partial decomposition of the heat-sensitive exo-methylenebenzocyclobutene moiety during the Heck steps, that lowered the efficiency of these usually high-yielding reactions and, consequently, of the overall 3-step process.
-
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35
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34548449643
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See Supporting information for details
-
See Supporting information for details.
-
-
-
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36
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34548459632
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In these cases, a larger excess of aryl bromide 4 equivs, was employed in order to reach maximum conversion before catalyst deactivation
-
In these cases, a larger excess of aryl bromide (4 equivs.) was employed in order to reach maximum conversion before catalyst deactivation.
-
-
-
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37
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0029066847
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G. R. Pettit, S. B. Singh, M. R. Boyd, E. Hamel, R. K. Pettit, J. M. Schmidt, F. Hogan, J. Med. Chem. 1995, 38, 1666-1672;
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33645865241
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42
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34548414374
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See Supporting information for a micrograph
-
See Supporting information for a micrograph.
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-
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43
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0035924931
-
-
Benzocyclobutenes are useful building blocks, especially in cycloaddition reactions: G. Mehta, S. Kotha, Tetrahedron 2001, 57, 625-659;
-
Benzocyclobutenes are useful building blocks, especially in cycloaddition reactions: G. Mehta, S. Kotha, Tetrahedron 2001, 57, 625-659;
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44
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0037963326
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A. K. Sadana, R. K. Saini, W E. Billups, Chem. Rev. 2003,103, 1539-1602.
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Sadana, A.K.1
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