Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models

BMC Biotechnology

Volumn 7, Issue , 2007, Pages

  Di Niro, Roberto ^a   Ziller, Federica ^a   Florian, Fiorella ^a   Crovella, Sergio ^a   Stebel, Marco ^a   Bestagno, Marco ^b   Burrone, Oscar ^b   Bradbury, Andrew R M ^c   Secco, Paola ^d   Marzari, Roberto ^a   Sblattero, Daniele ^d  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTIBODIES; DISEASES; IMMUNIZATION; PATHOGENS;

ANTI-TRANSGLUTAMINASE ANTIBODY; GENETIC FUSION; PHAGE DISPLAY ANTIBODY;

BIOMEDICAL ENGINEERING;

HOMODIMER; IMMUNOGLOBULIN FC FRAGMENT; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE LIBRARY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSGLUTAMINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE CONSTRUCT; GENE EXPRESSION; GENE FUSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DOMAIN; RAT; ANIMAL; AUTOIMMUNITY; CELIAC DISEASE; DISEASE MODEL; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METHODOLOGY; PROTEIN ENGINEERING;

ANIMALIA; MUS; RATTUS;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELIAC DISEASE; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, NATURAL; MICE; PEPTIDE LIBRARY; PROTEIN ENGINEERING; TRANSGLUTAMINASES;

EID: 34548402959     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-7-46     Document Type: Article

References (51)

1. Marrack P Kappler J Kotzin BL Autoimmune disease: Why and where it occurs Nature medicine 2001 7 8 899-905 10.1038/90935 11479621
2. Marks JD Hoogenboom HR Bonnert TP McCafferty J Griffiths AD Winter G By-passing immunization. Human antibodies from V-gene libraries displayed on phage J Mol Biol 1991 222 3 581-597 10.1016/ 0022-2836(91)90498-U 1748994
3. Sblattero D Bradbury A Exploiting recombination in single bacteria to make large phage antibody libraries Nature biotechnology 2000 18 1 75-80 10.1038/71958 10625396
4. Bradbury A Velappan N Verzillo V Ovecka M Chasteen L Sblattero D Marzari R Lou J Siegel R Pavlik P Antibodies in proteomics I: Generating antibodies Trends Biotechnol 2003 21 6 275-281 10.1016/ S0167-7799(03)00112-4 12788548
5. Bradbury A Velappan N Verzillo V Ovecka M Chasteen L Sblattero D Marzari R Lou J Siegel R Pavlik P Antibodies in proteomics II: Screening, high-throughput characterization and downstream applications Trends Biotechnol 2003 21 7 312-317 10.1016/S0167-7799(03)00117-3 12837616
6. McIntosh RS Asghar MS Watson PF Kemp EH Weetman AP Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: Evidence for in vivo antigen-driven repertoire selection J Immunol 1996 157 2 927-935 8752947
7. Roben P Barbas SM Sandoval L Lecerf JM Stollar BD Solomon A Silverman GJ Repertoire cloning of lupus anti-DNA autoantibodies J Clin Invest 1996 98 12 2827-2837 507750 8981931
8. Graus YF Verschuuren JJ Degenhardt A van Breda Vriesman PJ De Baets MH Posner JB Burton DR Dalmau J Selection of recombinant anti-HuD Fab fragments from a phage display antibody library of a lung cancer patient with paraneoplastic encephalomyelitis J Neuroimmunol 1998 82 2 200-209 10.1016/S0165-5728(97)00199-9 9585817
9. Graus YF de Baets MH Parren PW Berrih-Aknin S Wokke J van Breda Vriesman PJ Burton DR Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies J Immunol 1997 158 4 1919-1929 9029134
10. Jury K Sohnlein P Vogel M Richter W Isolation and functional characterization of recombinant GAD65 autoantibodies derived by IgG repertoire cloning from patients with type 1 diabetes Diabetes 2001 50 9 1976-1982 10.2337/diabetes.50.9.1976 11522662
11. Marzari R Sblattero D Florian F Tongiorgi E Not T Tommasini A Ventura A Bradbury A Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease J Immunol 2001 166 6 4170-4176 11238668
12. Goggins M Kelleher D Celiac disease and other nutrient related injuries to the gastrointestinal tract Am J Gastroenterol 1994 89 8 Suppl S2-17 8048412
13. Dieterich W Ehnis T Bauer M Donner P Volta U Riecken EO Schuppan D Identification of tissue transglutaminase as the autoantigen of celiac disease Nature medicine 1997 3 7 797-801 10.1038/nm0797-797 9212111
14. Sblattero D Florian F Azzoni E Zyla T Park M Baldas V Not T Ventura A Bradbury A Marzari R The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments European journal of biochemistry/FEBS 2002 269 21 5175-5181 10.1046/ j.1432-1033.2002.03215.x 12392549
15. Tjelle TE Corthay A Lunde E Sandlie I Michaelsen TE Mathiesen I Bogen B Monoclonal antibodies produced by muscle after plasmid injection and electroporation Mol Ther 2004 9 3 328-336 10.1016/j.ymthe.2003.12.007 15006599
16. Adorini L Tolerogenic Dendritic Cells Induced by Vitamin D Receptor Ligands Enhance Regulatory T Cells Inhibiting Autoimmune Diabetes Ann N Y Acad Sci 2003 987 258-261 12727648
17. Fang J Qian JJ Yi S Harding TC Tu GH VanRoey M Jooss K Stable antibody expression at therapeutic levels using the 2A peptide Nature biotechnology 2005 23 5 584-590 10.1038/nbt1087 15834403
18. Noel D Pelegrin M Kramer S Jacquet C Skander N Piechaczyk M High in vivo production of a model monoclonal antibody on adenoviral gene transfer Hum Gene Ther 2002 13 12 1483-1493 10.1089/10430340260185111 12215269
19. Lewis AD Chen R Montefiori DC Johnson PR Clark KR Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer J Virol 2002 76 17 8769-8775 136414 12163597 10.1128/JVI.76.17.8769-8775.2002
20. Tao MH Smith RI Morrison SL Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation J Exp Med 1993 178 2 661-667 10.1084/jem.178.2.661 8340761
21. Medgyesi GA Miklos K Kulics J Fust G Gergely J Bazin H Classes and subclasses of rat antibodies: Reaction with the antigen and interaction of the complex with the complement system Immunology 1981 43 1 171-176 1555175 7251048
22. Leatherbarrow RJ Dwek RA Binding of complement subcomponent C1q to mouse IgG1, IgG2a and IgG2b: A novel C1q binding assay Mol Immunol 1984 21 4 321-327 10.1016/0161-5890(84)90103-2 6610105
23. Esposito C Paparo F Caputo I Rossi M Maglio M Sblattero D Not T Porta R Auricchio S Marzari R Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ Gut 2002 51 2 177-181 1773330 12117875 10.1136/gut.51.2.177
24. Borrebaeck CA Carlsson R Human therapeutic antibodies Current opinion in pharmacology 2001 1 4 404-408 10.1016/S1471-4892(01)00070-4 11710740
25. Pack P Kujau M Schroeckh V Knupfer U Wenderoth R Riesenberg D Pluckthun A Improved bivalent miniantibodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Escherichia coli Biotechnology (N Y) 1993 11 11 1271-1277 7764189
26. Jain M Kamal N Batra SK Engineering antibodies for clinical applications Trends Biotechnol 2007 25 7 307-316 10.1016/j.tibtech.2007.05.001 17512622
27. Reff ME Heard C A review of modifications to recombinant antibodies: attempt to increase efficacy in oncology applications Crit Rev Oncol Hematol 2001 40 1 25-35 10.1016/S1040-8428(01)00132-9 11578914
28. Coloma MJ Morrison SL Design and production of novel tetravalent bispecific antibodies Nature biotechnology 1997 15 2 159-163 10.1038/ nbt0297-159 9035142
29. Batra SK Jain M Wittel UA Chauhan SC Colcher D Pharmacokinetics and biodistribution of genetically engineered antibodies Curr Opin Biotechnol 2002 13 6 603-608 10.1016/S0958-1669(02)00352-X 12482521
30. Shan D Press OW Tsu TT Hayden MS Ledbetter JA Characterization of scFv-Ig constructs generated from the anti-CD20 mAb 1F5 using linker peptides of varying lengths J Immunol 1999 162 11 6589-6595 10352275
31. Lu D Zhang H Koo H Tonra J Balderes P Prewett M Corcoran E Mangalampalli V Bassi R Anselma D A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity The Journal of biological chemistry 2005 280 20 19665-19672 10.1074/ jbc.M500815200 15757893
32. Kriangkum J Xu B Nagata LP Fulton RE Suresh MR Bispecific and bifunctional single chain recombinant antibodies Biomol Eng 2001 18 2 31-40 10.1016/S1389-0344(01)00083-1 11535414
33. Shahied LS Tang Y Alpaugh RK Somer R Greenspon D Weiner LM Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format The Journal of biological chemistry 2004 279 52 53907-53914 10.1074/jbc.M407888200 15471859
34. Chao H Monahan PE Liu Y Samulski RJ Walsh CE Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors Mol Ther 2001 4 3 217-222 10.1006/ mthe.2001.0449 11545612
35. Goudy K Song S Wasserfall C Zhang YC Kapturczak M Muir A Powers M Scott-Jorgensen M Campbell-Thompson M Crawford JM Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice Proceedings of the National Academy of Sciences of the United States of America 2001 98 24 13913-13918 61141 11717448 10.1073/pnas.251532298
36. Fischetti F Durigutto P Pellis V Debeus A Macor P Bulla R Bossi F Ziller F Sblattero D Meroni P Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor Blood 2005 106 7 2340-2346 10.1182/blood-2005-03-1319 15956288
37. Gould LH Sui J Foellmer H Oliphant T Wang T Ledizet M Murakami A Noonan K Lambeth C Kar K Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus J Virol 2005 79 23 14606-14613 1287547 16282460 10.1128/JVI.79.23.14606-14613.2005
38. Hong W Xiao S Zhou R Fang L He Q Wu B Zhou F Chen H Protection induced by intramuscular immunization with DNA vaccines of pseudorabies in mice, rabbits and piglets Vaccine 2002 20 7-8 1205-1214 10.1016/ S0264-410X(01)00416-9 11803083
39. Danko I Williams P Herweijer H Zhang G Latendresse JS Bock I Wolff JA High expression of naked plasmid DNA in muscles of young rodents Hum Mol Genet 1997 6 9 1435-1443 10.1093/hmg/6.9.1435 9285779
40. Yoshida A Nagata T Uchijima M Higashi T Koide Y Advantage of gene gun-mediated over intramuscular inoculation of plasmid DNA vaccine in reproducible induction of specific immune responses Vaccine 2000 18 17 1725-1729 10.1016/S0264-410X(99)00432-6 10699319
41. Tighe H Corr M Roman M Raz E Gene vaccination: Plasmid DNA is more than just a blueprint Immunol Today 1998 19 2 89-97 10.1016/ S0167-5699(97)01201-2 9509764
42. Nicolet CM Burkholder JK Gan J Culp J Kashmiri SV Schlom J Yang NS Sondel PM Expression of a tumor-reactive antibody-interleukin 2 fusion protein after in vivo particle-mediated gene delivery Cancer Gene Ther 1995 2 3 161-170 8528959
43. Prasad GL Lee HS Iwahashi M Milenic DE Abrams S Schlom J Kashmiri SV In vivo gene inoculation of a recombinant single-chain antitumor antibody induces anti-immunoglobulin response Cancer Gene Ther 1997 4 4 253-259 9253511
44. Benvenuti F Burrone OR Efremov DG Anti-idiotypic DNA vaccines for lymphoma immunotherapy require the presence of both variable region genes for tumor protection Gene therapy 2000 7 7 605-611 10.1038/ sj.gt.3301133 10819576
45. Benvenuti F Burrone OR Anti-idiotypic antibodies induced by genetic immunisation are directed exclusively against combined V(L)/V(H) determinants Gene therapy 2001 8 20 1555-1561 10.1038/sj.gt.3301546 11704816
46. Syrengelas AD Chen TT Levy R DNA immunization induces protective immunity against B-cell lymphoma Nature medicine 1996 2 9 1038-1041 10.1038/nm0996-1038 8782465
47. Sblattero D Berti I Trevisiol C Marzari R Tommasini A Bradbury A Fasano A Ventura A Not T Human recombinant tissue transglutaminase ELISA: An innovative diagnostic assay for celiac disease Am J Gastroenterol 2000 95 5 1253-1257 10.1111/j.1572-0241.2000.02018.x 10811336
48. Di Niro R Ferrara F Not T Bradbury AR Chirdo F Marzari R Sblattero D Characterizing monoclonal antibody epitopes by filtered gene fragment phage display Biochem J 2005 388 Pt 3 889-894 1183469 15720292
49. Chomczynski P Sacchi N Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 1987 162 1 156-159 10.1016/0003-2697(87)90021-2 2440339
50. Li E Pedraza A Bestagno M Mancardi S Sanchez R Burrone O Mammalian cell expression of dimeric small immune proteins (SIP) Protein Eng 1997 10 6 731-736 10.1093/protein/10.6.731 9278288
51. Hanke T Szawlowski P Randall RE Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen J Gen Virol 1992 73 Pt 3 653-660 1372038