Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1: Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 24816-24824

  Dunford, Adrian J ^a   McLean, Kirsty J ^a   Sabri, Muna ^a   Seward, Harriet E ^b   Heyes, Derren J ^a   Scrutton, Nigel S ^a   Munro, Andrew W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IRON REDUCTION; LASER PHOTOEXCITATION; MYCOBACTERIUM TUBERCULOSIS;

ABSORPTION; CARBON MONOXIDE; COMPLEXATION; CONCENTRATION (PROCESS); DISEASES; FERRITES; REACTION KINETICS;

BACTERIA;

CARBON MONOXIDE; CYTOCHROME; CYTOCHROME P420; CYTOCHROME P450; CYTOCHROME P450 121; CYTOCHROME P450 51B1; HEME; IRON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; BINDING SITE; COENZYME; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STABILITY; LASER; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH MEASUREMENT; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; REDUCTION; TITRIMETRY;

BACTERIAL PROTEINS; BINDING SITES; CARBON MONOXIDE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, BACTERIAL; HEME; HYDROGEN-ION CONCENTRATION; IRON; KINETICS; LASERS; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; PHOTOCHEMISTRY; SULFHYDRYL COMPOUNDS; TIME FACTORS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34548329954     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702958200     Document Type: Article

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