Synthesis of novel 4(5)-(5-aminotetrahydropyran-2-yl)imidazole derivatives and their in vivo release of neuronal histamine measured by brain microdialysis

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 8, 2007, Pages 1245-1253

  Harusawa, Shinya ^a   Kawamura, Makoto ^a   Araki, Lisa ^a   Taniguchi, Ryusuke ^a   Yoneyama, Hiroki ^a   Sakamoto, Yasuhiko ^b   Kaneko, Noritsugu ^b   Nakao, Yumi ^c   Hatano, Kouta ^c   Fujita, Takeshi ^c   Yamamoto, Ryoko ^c   Kurihara, Takushi ^a   Yamatodani, Atsushi ^c  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b Alfresa Pharma Corporation   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Antagonist; Cyclization; H3; Imidazole; Microdialysis; Tetrahydropyran

Indexed keywords

4(5) (5 AMINOTETRAHYDROPYAN 2 YL)IMIDAZOLE; BUTYLAMINE; CHLORPROPHAM; CYCLOHEXYLTHIOUREA; FUNCTIONAL GROUP; GLUTAMINE; GUANIDINE DERIVATIVE; HISTAMINE; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE; IMMEPIP; OUP 133; OUP 153; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; CYCLIZATION; DRUG CONFORMATION; DRUG EFFECT; DRUG SYNTHESIS; ENANTIOMER; HISTAMINE RELEASE; IN VIVO STUDY; MALE; METHODOLOGY; MICRODIALYSIS; NERVE CELL; NONHUMAN; RAT; STEREOISOMERISM;

ANIMALS; BRAIN CHEMISTRY; HISTAMINE; HISTAMINE RELEASE; IMIDAZOLES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICRODIALYSIS; MOLECULAR CONFORMATION; NEURONS; PYRANS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM;

EID: 34548316730     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1245     Document Type: Article

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