Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)- cyclopropylamine

Journal of Medicinal Chemistry

Volumn 42, Issue 7, 1999, Pages 1115-1122

  De Esch, Iwan J P ^a   Vollinga, Roeland C ^a   Goubitz, Kees ^b   Schenk, Henk ^b   Appelberg, Ulf ^c   Hacksell, Uli ^c   Lemstra, Sylvia ^a   Zuiderveld, Obbe P ^a   Hoffmann, Marcel ^a   Leurs, Rob ^a   Menge, Wiro M P B ^a   Timmerman, Henk ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1H IMIDAZOL 4 YL)CYCLOPROPYLAMINE; CYCLOPROPYLHISTAMINE; HISTAMINE DERIVATIVE; HISTAMINE H3 RECEPTOR; PROPYLAMINE; UNCLASSIFIED DRUG; VUF 5296; VUF 5297;

ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN CORTEX; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GUINEA PIG; JEJUNUM; MOLECULAR MODEL; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; GUINEA PIGS; HEART RATE; HISTAMINE; HISTAMINE AGONISTS; ILEUM; JEJUNUM; MODELS, MOLECULAR; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; RATS; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H2; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033535567     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9810912     Document Type: Article

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