Sleeping with the hypothalamus: Emerging therapeutic targets for sleep disorders

Nature Neuroscience

Volumn 5, Issue 11s, 2002, Pages 1071-1075

  Mignot, Emmanuel ^a   Taheri, Shahrad ^a   Nishino, Seiji ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBUTYRIC ACID; ADENOSINE A1 RECEPTOR AGONIST; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; BENZODIAZEPINE DERIVATIVE; CENTRAL STIMULANT AGENT; CLONAZEPAM; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; GABAPENTIN; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HYPNOTIC AGENT; MELATONIN; MODAFINIL; NEUROPEPTIDE; OPIATE; OREXIN; OREXIN ANTAGONIST; SEDATIVE AGENT; SEROTONIN 2A ANTAGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 3 ANTAGONIST; TRAZODONE; UNCLASSIFIED DRUG; ZALEPLON; ZOLPIDEM; ZOPICLONE;

DOPAMINERGIC SYSTEM; GABAERGIC SYSTEM; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; INSOMNIA; NARCOLEPSY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RESTLESS LEGS SYNDROME; REVIEW; SIDE EFFECT; SLEEP DISORDER; SLEEP PATTERN;

ANIMALS; CARRIER PROTEINS; CIRCADIAN RHYTHM; DRUG DESIGN; HUMANS; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURAL PATHWAYS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; SLEEP; SLEEP DISORDERS;

EID: 0036828979     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn944     Document Type: Review

References (36)

1. Kryger, M., Roth, T. & Dement, W. C. Principles and Practice of Sleep Medicine 3rd edn. (WB Saunders Company, New York, 2000).
2. Van Economo, C. Sleep as a problem of localization. J. Nerv. Mental Disease 71, 249-269 (1931).
3. Bernardis, L. L. & Bellinger, L. L. The lateral hypothalamic area revisited: ingestive behavior. Neurosc. Behav. Rev. 20, 189-287 (1996).
4. Moruzzi, G. & Magoun, H. W. Brain stem reticular formation and activation of the EEG. Electroencephalogr. Clin. Neurophysiol. 1, 455-473 (1949).
5. Rechtschaffen, A., Bergmann, B. M., Everson, C. A., Kushida, C. A. & Gilliland, M. A. Sleep deprivation in the rat: X. Integration and discussion of the findings. Sleep 25, 68-87 (2002).
6. Spiegel, K., Leproult, R. & Van Cauter, E. Impact of sleep debt on metabolic and endocrine function. Lancet 354, 1435-1439 (1999).
7. Pace-Schott, E. F. & Hobson, J. A. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat. Rev. Neurosci. 3, 591-605 (2002).
8. Steriade, M. Arousal: revisiting the reticular activating system. Science 272, 225-226 (1996).
9. Wisor, J. P., Nishino, S., Sora, I., Uhl, G. H., Mignot, E. & Edgar, D. M. Dopaminergic role in stimulant-induced wakefulness. J. Neurosci. 21, 1787-1794 (2001).
10. Miller, J. D., Farber, J., Gatz, P., Roffwarg, H. & German, D. C. Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and walking in the rat. Brain Res. 273, 133-141 (1983).
11. Rye, D. B. & Jankovic, J. Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD. Neurology 58, 341-346 (2002).
12. Lu, J., Xu, M. & Saper, C. B. Identification of wake-active dopaminergic neurons in the ventral periaqueducal gray. Sleep 25, supplement, A290 (2002).
13. Smith, T. A. Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment. Br. J. Biomed. Sci. 58, 111-121 (2001).
14. Crestani, F., Martin, J. R., Mohler, H. & Rudolph, U. Mechanism of action of the hypnotic zolpidem in vivo. Br. J. Pharmacol. 131, 1251-1254 (2000).
15. Tobler, I., Kopp, C., Deboer, T. & Rudolph, U. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc. Natl. Acad. Sci. USA 98, 6464-6469 (2001).
16. Bernasconi, R., Mathivet, P., Bischoff, S. & Marescaux, C. Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential? Trends Pharmacol. Sci. 20, 135-141 (1999).
17. Strecker, R. E. et al. Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study. Neuroscience 113, 663-670 (2002).
18. Parmentier, R., Ohtsu, H., Djebbara-Hannas, Z., Valatx, J. L., Watanabe, T. & Lin, J. S. Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control. J. Neurosci. 22, 7695-7711 (2002).
19. Dugovic, C. et al. Sleep in mice lacking the histamine H3 receptor, a putative genetic animal model for REM behavior disorder. Sleep 25, supplement, A114 (2002).
20. Beuckmann, C. T. & Yanagisawa, M. Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J. Mol. Med. 80, 329-342 (2002).
21. Taheri, S., Zeitzer, J. M. & Mignot, E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25, 283-313 (2002).
22. Marcus, J. N. et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435, 6-25 (2001).
23. Yoshida, Y. et al. Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci. 14, 1075-1081 (2001).
24. Kiyashchenko, L. I. et al. Release of hypocretin (orexin) during waking and sleep states. J. Neurosci. 22, 5282-5286 (2002).
25. Yamanaka, A. et al. Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem. Biophys. Res. Commun. 290, 1237-1245 (2002).
26. Saper, C. B., Chou, T. C. & Scammell, T. E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24, 726-731 (2001).
27. Suntsova, N., Szymusiak, R., Alam, M. N., Guzman-Marin, R. & McGinty, D. Sleep-waking discharge patterns of median preoptic nucleus neurons in rats. J. Physiol. 543, 665-677 (2002).
28. Dijk, D. J. & Czeisler, C. A. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosc. Lett. 166, 63-68 (1994).
29. Edgar, D. M., Dement, W. C. & Fuller, C. A. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J. Neurosci. 13, 1065-1079 (1993).
30. Wager-Smith, K. & Kay, S. A. Circadian rhythm genetics: from flies to mice to humans. Nat. Genet. 26, 23-27 (2000).
31. Kramer, A. et al. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294, 2511-2515 (2001).
32. Cheng, M. Y. et al. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417, 405-410 (2002).
33. Shaw, P. J., Tononi, G., Greenspan, R. J. & Robinson, D. F. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417, 287-291 (2002).
34. Naylor, E. et al. The circadian clock mutation alters sleep homeostasis in the mouse. J. Neurosci. 20, 8138-8143 (2000).
35. Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjorkum, A. A., Greene, R. W. & McCarley, R. W. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276, 1265-1268 (1997).
36. Kubin, L., Tojima, H., Reignier, C., Pack, A. I. & Davies, R. O. Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia. Sleep 19, 187-195 (1996).