Type 1 and type 2 responses to Leishmania major

FEMS Microbiology Letters

Volumn 209, Issue 1, 2002, Pages 1-7

  Rogers, Kathleen A ^a   DeKrey, Gregory K ^a   Mbow, M Lamine ^a   Gillespie, R Dean ^a   Brodskyn, Claudia I ^a   Titus, Richard G ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Antigen presenting cell; Co stimulation; Cytokine; Leishmaniasis; Sand fly; Th cell

Indexed keywords

BLOCKING ANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; MAXADILAN; PROTOZOAL VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; CELL GROWTH; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE TRANSMISSION; PARASITE VECTOR; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; VACCINATION;

LEISHMANIA MAJOR; MAMMALIA; PHLEBOTOMINAE; PROTOZOA;

EID: 0037133751     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(02)00470-6     Document Type: Review

References (45)

1. Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity
2. Cytokines in parasitic diseases: The example of cutaneous leishmaniasis
3. The host response to Leishmania infection
4. Progressive disease or protective immunity to Leishmania major infection: The result of a network of stimulatory and inhibitory interactions
5. Susceptibility to Leishmania major infection in interleukin-4-deficient mice
6. IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
7. IL-13 is a susceptibility factor for Leishmania major infection
8. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
9. The role of IL-10 in promoting disease progression in leishmaniasis
10. BALB/c mice bearing a transgenic IL-12 receptor β2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling
11. The role of dendritic cells at the early stages of Leishmania infection
12. Immunobiology of dendritic cells
13. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
14. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
15. Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: A paradigm reconsidered
16. Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection
17. Leishmania major induces differential expression of co-stimulatory molecules on mouse epidermal cells
18. Blockade of CD86 ameliorates Leishmania major infection by downregulating the Th2 response
19. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis
20. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
21. Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis
22. Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF
23. The role of nitric oxide in innate immunity
24. Transforming growth factor-β in leishmanial infection: A parasite escape mechanism
25. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection
26. An in vitro model for infection with Leishmania major that mimics the immune response in mice
27. + T cells
28. Interleukin-6-deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease
29. Phlebotomus papatasi sand fly salivary gland lysate downregulates a Th1, but upregulates a Th2, response in mice infected with Leishmania major
30. Development of a natural model of cutaneous leishmaniasis: Powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis
31. The immunomodulatory factors of bloodfeeding arthropod saliva
32. The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections
33. Toward a defined anti-Leishmania vaccine targeting vector antigens: Characterization of a protective salivary protein
34. Sand fly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection
35. Immunology of leishmaniasis
36. American cutaneous leishmaniasis: In situ characterization of the cellular immune response with time
37. T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: Immunologic patterns associated with cure
38. Regulator and effector functions of T-cell subsets in human Leishmania infections
39. Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major
40. Cell mediated immunity in American cutaneous and mucosal leishmaniasis
41. Functional and phenotypic changes in human lymphocytes after coincubation with Leishmania donovani in vitro
42. Interleukin-4 and interferon-gamma production by Leishmania stimulated peripheral blood mononuclear cells from nonexposed individuals
43. -) Leishmania major elicit predominantly a type 1 cytokine response by human cells in vitro
44. Influence of costimulatory molecules on the immune response to Leishmania major by human cells in vitro