Epidural, intrathecal pharmacokinetics, and intrathecal bioavailability of ropivacaine

Anesthesia and Analgesia

Volumn 105, Issue 3, 2007, Pages 859-867

  Rose, François Xavier ^a   Estebe, Jean Pierre ^a   Ratajczak, Maja ^a   Wodey, Eric ^a   Chevanne, François ^a   Dollo, Gilles ^a   Bec, David ^a   Malinovsky, Jean Marc ^a   Ecoffey, Claude ^a   Le Corre, Pascal ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; ETIDOCAINE; ROPIVACAINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG TISSUE LEVEL; EPIDURAL SPACE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; SHEEP; SPINAL CORD; TIME; VARIANCE;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; BIOLOGICAL AVAILABILITY; EPIDURAL SPACE; FEMALE; INJECTIONS, EPIDURAL; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; MICRODIALYSIS; MODELS, ANIMAL; MODELS, BIOLOGICAL; SHEEP; SPINAL CORD; TISSUE DISTRIBUTION;

EID: 34548143000     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000278129.37099.fa     Document Type: Article

References (31)

1. Covino BG, Wildsmith JAW. Neural blockade in clinical anesthesia and management of pain. In: Cousins MJ, Bridenbaugh PO, eds. Clinical Pharmacology of Local Anesthétic Agents. 3rd ed. Philadelphia, PA: Lippincott-Raven Publishers, 1998:97-128
2. Liu SS, Carpenter RL, Neal JM. Epidural anesthesia and analgesia: their role in postoperative outcome. Anesthesiology 1995;82:1474-506
3. Cederholm I. Preliminary risk-benefit analysis of ropivacaïne in labour following surgery. Drug Saf 1997;16:391-402
4. Knudsen K, Beckman Suurkula M, Blomberg S, Sjovall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997;78:507-14
5. Clément R, Malinovsky JM, Le Corre P, Dollo G, Chevanne F, Le Verge R. Cerebrospinal fluid bioavailability and pharmacokinetics of ropivacaïne and lidocaine following intrathecal and epidural administrations in rabbits using microdialysis. J Pharmacol Exp Ther 1999;289:1015-21
6. Clément R, Malinovsky JM, Hildgen P, Dollo G, Estebe JP, Chevanne F, Le Verge R, Le Corre P. Spinal disposition and meningeal permeability of local anesthetics. Pharm Res 2004;4:706-16
7. Bernards CM, Shen DD, Sterling ES, Adkins JE, Risler L, Phillips B, Ummenhofer W. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1). Anesthesiology 2003;99:455-65
8. Bernards CM, Shen DD, Sterling ES, Adkins JE, Risler L, Phillips B, Ummenhofer W. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2). Anesthesiology 2003;99:466-75
9. Clément R, Malinovsky JM, Le Corre P, Dollo G, Chevanne F, Le Verge R. Spinal biopharmaceutics of ropivacaïne and lidocaine by microdialysis after their simultaneous administration in rabbits. Int J Pharm 2000;203:227-34
10. Scheller D, Kolb J. The internal reference technique in microdialysis: a practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples. J Neurosci Methods 1991;40:31-8
11. Wang Y, Wong SL, Sawchuk RJ. Microdialysis calibration for the measurement of carbamazepine and its metabolits. Pharm Res 1993;10:1411-19
12. Lonroth P, Jansson PA, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 1987;253:E228-31
13. Reif S, Le Corre P, Chevanne F, Le Verge R. High-performance liquid chromatographic determination of ropivacaïne, 3-hydroxy-ropivacaïne, 4-hydroxy-ropivacaïne and 2′,6′-pipecoloxylidide in plasma. J Chromatogr 1998;719:239-44
14. Santos A, Arthur GR, Lehning EJ, Finster M. Comparative pharmacokinetics of ropivacaïne and bupivacaïne in non pregnant ewes. Anesth Analg 1997;85:87-93
15. Mather LE, Runciman WB, Carapetis RJ, Ilsley AH, Upton RN. Hepatic and renal clearances of lidocaine in conscious and anesthetized sheep. Anesth Analg 1986;65:943-9
16. Burney RG, DiFazio CA. Hepatic clearance of lidocaine during N2O anesthesia in dogs. Anesth Analg 1976;55:322-5
17. Algotsson L, Messeter K, Nordstrom CH, Ryding E. Cerebral blood flow and oxygen consumption during isoflurane and halothane anesthesia in man. Acta Anaesthesiol Scand 1988;32:15-20
18. Frink EJ Jr, Morgan SE, Coetzee A, Conzen PF, Brown BR Jr. The effects of sevoflurane, halothane, enflurane, and isoflurane on hepatic blood flow and oxygenation in chronically instrumented greyhound dogs. Anesthesiology 1992;76:85-90
19. Grundmann U, Zissis A, Bauer C, Bauer M. In vivo effects of halothane, enflurane, and isoflurane on hepatic sinusoidal microcirculation. Acta Anaesthesiol Scand 1997;41:760-5
20. Rutten AJ, Mather LE, Nancarrow C, Sloan PA, McLean CF. Cardiovascular effects and regional clearances of intravenous ropivacaine in sheep. Anesth Analg 1990;70:577-82
21. Burm AG, Haak-van der Lely F, van Kleef JW, Jacobs CJ, Bovill JG, Vletter AA, van den Heuvel RP, Onkenhout W. Pharmacokinetics of alfentanil after epidural administration. Investigation of systemic absorption kinetics with a stable isotope method. Anesthesiology 1994;81:308-15
22. Emanuelsson BM, Persson J, Alm C, Heller A, Gustafsson LL. Systemic absorption and block after epidural injection of ropivacaine in healthy volunteers. Anesthesiology 1997;87:1309-17
23. Veering BT, Burm AG, Vletter AA, van den Hoeven RA, Spierdijk J. The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration. Anesthesiology 1991;74:250-7
24. Shafer SL, Shafer A. Spinal pharmacokinetics. In: Yaksh TL, ed. Spinal Drug Delivery. Amsterdam: Elsevier Science BV, 1999:271-95
25. Shafer SL, Eisenach JC, Hood DD, Tong C. Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans. Anesthesiology 1998;89:1074-88
26. Castro MI, Eisenach JC. Pharmacokinetics and dynamics of intravenous, intrathecal, and epidural clonidine in sheep. Anesthesiology 1989;71:418-25
27. Hansdottir V, Hedner T, Woestenborghs R, Nordberg G. The CSF and plasma pharmacokinetics of sufentanil after intrathecal administration. Anesthesiology 1991;74:264-9
28. Hansdottir V, Woestenborghs R, Nordberg G. The cerebrospinal fluid and plasma pharmacokinetics of sufentanil after intrathecal administration. Anesthesiology 1995;80:724-9
29. Sjostrom S, Tamsen A, Persson M, Hartvig P. Pharmacokinetics of intrathecal morphine and meperidine in humans. Anesthesiology 1987;67:877-88
30. Nordberg G, Hedner T, Mellstrand T, Borg L. Pharmacokinetics of epidural morphine in man. Eur J Clin Pharmacol 1984;26:233-7
31. Nordberg G, Hansdottir V, Bondesson U, Boreus LO, Mellstrand T, Hedner T. CSF and plasma pharmacokinetics of pethidine and norpethidine in man after epidural and intrathecal administration of pethidine. Eur J Clin Pharmacol 1988;34:625-31