Cerebrospinal fluid bioavailability and pharmacokinetics of bupivacaine and lidocaine after intrathecal and epidural administrations in rabbits using microdialysis

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 1015-1021

  Clement, Rozenn ^a   Malinovsky, Jean Marc ^a   Le Corre, Pascal ^a   Dollo, Gilles ^a   Chevanne, Francois ^a   Le Verge, Roger ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; ETIDOCAINE; LIDOCAINE; ROPIVACAINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; CALIBRATION; CONFERENCE PAPER; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; EPIDURAL DRUG ADMINISTRATION; FEMALE; INTRATHECAL DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANESTHETICS, LOCAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BUPIVACAINE; FEMALE; HALF-LIFE; INJECTIONS, EPIDURAL; INJECTIONS, SPINAL; LIDOCAINE; MICRODIALYSIS; RABBITS;

EID: 0032960974     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (39)

1. Bernards CM and Hill HF (1990) Morphine and alfentanil permeability through the spinal dura, arachnoid, and pia mater of dogs and monkeys. Anesthesiology 73: 1214-1219.
2. Bernards CM, Kopacz DJ and Michel MZ (1994) Effect of needle puncture on morphine and lidocaine through the spinal meninges of the monkey in vitro. Anesthesiology 80:853-858.
3. Boogaerts JG, Lafont ND, Carlino S, Noel E, Raynal F, Goffinet G and Legros FJ (1995) Biodistribution of liposome-associated bupivacaine after extradural administration to rabbits. Br J Anaesth 75:319-325.
4. Burm AGL, Van Kleef JW, Gladines MB, Spierdijk J and Breimer DD (1983) Plasma concentrations of lidocaine and bupivacaine after subarachnoid administration. Anesthesiology 59:191-195.
5. Castro MI and Eisenach JC (1989) Pharmacokinetics and dynamics of intravenous, intrathecal, and epidural clonidine in sheep. Anesthesiology 71:418-425.
6. Clément R, Malinovsky JM, Dollo G, Le Corre P, Chevanne F and Le Verge R (1998) In vitro and in vivo microdialysis calibration using retrodialysis for the study of the cerebrospinal distribution of bupivacaine. J Pharm Biomed Anal 17:665-670.
7. Cohen EN (1968) Distribution of local anesthetic agents in the neuraxis of the dog. Anesthesiology 79:1002-1005.
8. Covino BG and Wildsmith JAW (1998) Clinical pharmacology of local anesthetic agents, in Neural Blockade in Clinical Anesthesia and Management of Pain, 3rd ed. (Cousins MJ and Bridenbaugh PO eds) pp 97-128, Lippincott-Raven Publishers, Philadelphia.
9. Deleu D, Sarre S, Ebinger G and Michotte Y (1995) The effect of carbidopa and entacapone pretreatment on the L-dopa pharmacokinetics and metabolism in blood plasma and skeletal muscle in beagle dog: An in vivo microdialysis study. J Pharmacol Exp Ther 273:1323-1331.
10. Denson D, Coyle D, Thompson G and Myers J (1984) Alpha1-acid glycoprotein and albumin in human serum bupivacaine binding. Clin Pharmacol Ther 35:409-415.
11. Doherty MM, Hughes PJ, Korszniak NV and Charman WN (1995) Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: Pharmacodynamic and pharmacokinetic studies in the rabbit. Anesth Analg 80:740-746.
12. Durant PA and Yaksh TL (1986) Distribution in cerebrospinal fluid, blood, and lymph of epidurally injected morphine and inulin in dogs. Anesth Analg 65:583-592.
13. Eisenach J, Deitweiler D and Hood D (1993) Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology 78:277-287.
14. Eisenach JC, Hood DD, Tuttle R, Shafer S, Smith T and Tong C (1995) Computer-controlled epidural infusion to targeted cerebrospinal fluid concentrations in humans: Clonidine. Anesthesiology 83:33-47.
15. Fréville JC, Dollo G, Le Corre P, Chevanne F and Le Verge R (1996) Controlled systemic absorption and increased anesthetic effect of bupivacaine following epidural administration of bupivacaine-hydroxypropyl-β-cyclodextrin complex. Pharm Res 13:1574-1578.
16. Gourlay GK, Cherry DA, Plummer JL, Armstrong PJ and Cousins MJ (1987) The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: Application to morphine and pethidine. Pain 38:297-305.
17. Greene NM (1983) Uptake and elimination of local anesthetics during spinal anesthesia. Anesth Analg 62:1013-1024.
18. Hansdottir V, Hedner T, Woestenborghs R and Nordberg G (1991) The CSF and plasma pharmacokinetics of sufentanil after intrathecal administration. Anesthesiology 74:264-269.
19. Hansdottir V, Woestenborghs R and Nordberg G (1995) The cerebrospinal fluid and plasma pharmacokinetics of sufentanil after thoracic and lumbar epidural administration. Anesth Analg 80:724-729.
20. Le Corre P, Estebe JP, Chevanne F, Mallédant Y and Le Verge R (1995) Spinal controlled delivery of bupivacaine from DL-lactic oligomer microspheres. J Pharm Sci 84:75-78.
21. Le Guevello P, Le Corre P, Chevanne F and Le Verge R (1993) High-performance liquid chromatographic determination of bupivacaine in plasma samples for biopharmaceutical studies and application to seven other local anesthetics. J Chromatogr 622:284-290.
22. Malinovsky JM, Bernard JM, Baudrimont M, Dumand JB and Lepage JY (1997) A chronic model for experimental investigation of epidural anesthesia in rabbit. Reg Anesth 22:80-85.
23. McEllistrem RF, Bennington RG and Roth SH (1993) In vitro determination of human dura permeability to opioids and local anaesthetics. Can J Anaesth 40: 165-169.
24. McNamara PJ, Slaughter RL, Pieper JA, Wyman MG and Lalka D (1981) Factors influencing serum protein binding of lidocaine in humans. Anesth Analg 60:395-400.
25. Moore RA, Bullingham RES, McQuay HJ, Hand CW, Aspel JB, Allen MC and Thomas D (1982) Dural permeability to narcotics: In vitro determination and application to extradural administration. Br J Anaesth 54:1117-1128.
26. Nordberg G, Hedner T, Mellstrand T and Borg L (1984) Pharmacokinetics of epidural morphine in man. Eur J Clin Pharmacol 26:233-237.
27. Nordberg G, Hedner T, Mellstrand T and Dahlström B (1983) Pharmacokinetics aspects of epidural morphine analgesia. Anesthesiology 58:545-551.
28. Paul DL and Wildsmith JAW (1989) Extradural pressure following the injection of two volumes of bupivacaine. Br J Anaesth 62:368-372.
29. Rigler ML and Drasner K (1991) Distribution of catheter-injected local anesthetic in a model of subarachnoid space. Anesthesiology 75:684-692.
30. Rosenberg PH, Kytta J and Alila A (1986) Absorption of bupivacaine, etidocaine, lignocaine and ropivacaine into n-heptane, rat sciatic nerve, and human extradural and subcutaneous fat. Br J Anaesth 58:310-314.
31. Scheller D and Kolb J (1991) The internal reference technique in microdialysis: A practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples. J Neurosci Methods 40:31-38.
32. Shafer SL, Eisenach JC, Hood DD and Tong C (1998) Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans. Anesthesiology 89:1074-1088.
33. Sjostrom S, Hartvig P, Persson M and Tamsen A (1987a) Pharmacokinetics of epidural morphine and meperidine in humans. Anesthesiology 67:877-888.
34. Sjostrom S, Tamsen A, Persson M and Hartvig P (1987b) Pharmacokinetics of intrathecal morphine and meperidine in humans. Anesthesiology 67:889-895.
35. Taverne RHT, Ionescu TI and Nuyten STM (1992) Comparative absorption and distribution pharmacokinetics of intravenous and epidural sufentanil for major abdominal surgery. Clin Pharmacokinet 23:231-237.
36. Tucker GT and Mather LE (1998) Physicochemical properties, absorption, and disposition of local anesthetic, in Neural Blockade in Clinical Anesthesia and Management of Pain, 2nd ed. (Cousins MJ and Bridenbaugh PO eds) pp 47-110, Lippincott-Raven Publishers, Philadelphia.
37. Vandenabeele F, Creemers J and Lambrichts I (1996) Ultrastructure of the human spinal arachnoid mater and dura mater. J Anat 189:417-430.
38. Wang Y, Wong SL and Sawchuk RJ (1993) Microdialysis calibration using retrodialysis and zero-net flux: Application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus. Pharm Res 10:1411-1419.
39. Wilkinson GR and Lund PC (1970) Bupivacaine levels in plasma and cerebrospinal fluid following peridural administration. Anesthesiology 33:482-486.