Polymorphism in the 3′ UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy

Microbes and Infection

Volumn 9, Issue 9, 2007, Pages 1049-1052

  Zafra, German ^a   Morillo, Carlos ^b   Martín, Javier ^c   González, Antonio ^c   González, Clara Isabel ^a  

^a Grupo de Inmunología y Epidemiología Molecular   (Colombia)

^b FUNDACIÓN CARDIOVASCULAR DE COLOMBIA   (Colombia)

^c INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Chagas' disease; Interleukin 12; Polymorphism; Trypanosoma cruzi

Indexed keywords

INTERLEUKIN 12 RECEPTOR; IL12B PROTEIN, HUMAN; INTERLEUKIN 12P40; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ARTICLE; BACTERIAL GENE; CHAGAS DISEASE; COLOMBIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENDEMIC DISEASE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STATISTICAL SIGNIFICANCE; TRYPANOSOMA CRUZI; ANIMAL; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; PARASITOLOGY;

TRYPANOSOMA CRUZI;

3' UNTRANSLATED REGIONS; ADULT; ANIMALS; CHAGAS CARDIOMYOPATHY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TRYPANOSOMA CRUZI;

EID: 34548132097     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2007.04.010     Document Type: Article

References (30)

1. Tarleton R.L. Chagas disease: a role for autoimmunity?. Trends Parasitol. 19 (2003) 447-451
2. Nieto A., Beraun Y., Collado M.D., Caballero A., Alonso A., Gonzalez A., and Martin J. HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection. Tissue Antigens 55 (2000) 195-198
3. Moreno M., Silva E.L., Ramirez L.E., Palacio L.G., Rivera D., and Arcos-Burgos M. Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10. Tissue Antigens 64 1 (2004) 18-24
4. Calzada J.E., Nieto A., Beraun Y., and Martin J. Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy. Tissue Antigens 58 (2001) 154-158
5. Flórez O., Zafra G., Morillo C., Martín J., and González C.I. Interleukin-1 gene cluster polymorphism in Chagas Disease in a Colombian case-control study. Human Immunol. 67 (2006) 741-748
6. Ramasawmy R., Cunha-Neto E., Fae K.C., Muller N.G., Cavalcanti V.L., Drigo S.A., Ianni B., Mady C., Kalil J., and Goldberg A.C. BAT1 a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy. J. Infect. Dis. 193 10 (2006) 1394-1399
7. Watford W.T., Moriguchi M., Morinobu A., and O'Shea J.J. The biology of IL-12: coordinating innate and adaptative immune responses. Cytokine Growth Factor Rev. 14 (2003) 361-368
8. Antúnez M.I., and Cardoni R.L. IL-12 and IFN-γ production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections. Immunol. Lett. 71 (2000) 103-109
9. Michailowski V., Silva N.M., Rocha C.D., Vieira L.Q., Lannes-Vieira J., and Gazzinelli R.T. Pivotal role of interleukin-12 and interferon-γ axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection. Am. J. Pathol. 159 (2001) 1723-1733
10. Graefe S.E.B., Jacobs T., Gaworski I., Klauenberg U., Steeg C., and Fleischer B. Interleukin-12 but not interleukin-18 is required for immunity to Trypanosoma cruzi in mice. Microbes Infect. 5 (2003) 33-39
11. Trinchieri G., Pflanz S., and Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19 (2003) 641-644
12. Huang D., Cancilla M.R., and Morahan G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun. 1 (2000) 515-520
13. Hall M.A., McGlinn E., Coakley G., Fisher S.A., Boki K., Kaklamani E., Moutsopoulos Jr. H., Loughran T.P., Ollier W.E.R., Panayi G.S., and Lanchbury J.S. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun. 1 (2000) 219-224
14. Seegers D., Zwiers A., Strober W., Peña A.S., and Bouma G. A Taq polymorphism in the 3′UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. Genes Immun. 3 (2002) 419-423
15. Morahan G., Boutlis C.S., Huang D., Pain A., Saunders J.R., Hobbs M.R., Granger D.L., Weinberg J.B., Peshu N., Mwaikambo E.D., Marsh K., Roberts D.J., and Anstey N.M. A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun. 3 (2002) 414-418
16. Gutiérrez R., Angulo V.M., Tarazona Z., Britto C., and Fernandes O. Comparison of four serological test for the diagnosis of Chagas Disease in a Colombian endemic area. Parasitology 129 (2004) 439-444
17. Rocha M.O. Clinical management of chronic Chagas cardiomyopathy. Front Biosci. 8 (2003) e44-e54
18. Schneider S., Roessli D., Excoffier L., and Arlequin ver. A Software for Population Genetics Data Analysis. Genetics and Biometry Laboratory (2000), University of Geneva, Switzerland
19. Sánchez E., Morales S., Paco L., López-Nevot M.A., Hidalgo C., Jiménez-Alonso J., Torres B., González-Gay M.A., Callejas J.L., Ortego-Centeno N., Sánchez-Roman J., González-Escribano M.F., and Martin J. Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) an interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. Rheumatology 44 (2005) 1136-1139
20. In: Hartl D.L., and Clark A.G. (Eds). Principles of Population Genetics (1989), Sinauer Associate Inc Publishers, Sunderland-Massachusetts 293-298
21. Yilmaz V., Yentur S.P., and Saruhan-Direskeneli G. IL12 and IL10 polymorphisms and their effects on cytokine production. Cytokine 30 (2005) 188-194
22. Stanilova S., and Miteva L. Taq-I polymorphism in 3′ UTR of the IL-12B and association with production from human PBMC. Genes Immun. 6 (2005) 364-366
23. Brodskyn C., Patricio J., Oliveira R., Lobo L., Arnholdt A., Mendonca-Previato L., Barral A., and Barral-Netto M. Glycoinositolphospholipids from Trypanosoma cruzi interfere with macrophages and dendritic cell responses. Inf. Immun. 70 (2002) 3736-3743
24. Campos M.A., Closel M., Valente E.P., Cardoso J.E., Akira S., Alvarez-Leite J.I., Ropert C., and Gazzinelli R.T. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J. Immunol. 172 (2004) 1711-1718
25. Oliveira A.C., Peixoto J.R., Arruda L.C., Campos M.A., Gazzinelli R.T., Golenbock D.T., Akira S., Previato J.O., Mendonca-Previato L., Nobrega A., and Bellio M. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J. Immunol. 173 (2004) 5688-5696
26. Reis D.D., Jones E.M., Tostes S., Gazzinelli G., Colley D.G., and McCurley T. Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of TNF-alpha+ cells and dominance of Granzyme A+, CD8+ lymphocytes. Am. J. Trop. Med. Hyg. 43 (1993) 637-644
27. Schuman A.G., Vigliano C.A., Viotti R.J., Burgos J.M., Brandariz S., Lococo B.E., Leze M.I., Armenti H.A., and Levin M.J. Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic Chagas heart disease. Am. J. Trop. Med. Hyg. 70 (2004) 210-220
28. Gomes J.A.S., Bahía-Oliveira L.M.G., Rocha M.O.C., Martins-Filho A.O., Gazzinelli G., and Correa-Oliveira R. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect. Immun. 71 (2003) 1185-1193
29. Oliveira M.A.P., Santiago H.C., Lisboa C.R., Ceravollo I.P., Trinchieri G., Gazzinelli R.T., and Vieira L.Q. Leishmaniasp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-γ synthesis. Exp. Parasitol. 95 (2000) 96-105
30. Cunha-Neto E., Dzau V.J., Allen P.D., Stamatiou D., Benvenutti L., Higuchi M.L., Koyama N.S., Silva J.S., Kalil J., and Liew C.C. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am. J. Pathol. 167 (2005) 305-313