A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production

Genes and Immunity

Volumn 3, Issue 7, 2002, Pages 414-418

  Morahan, G ^a,h   Boutlis, C S ^b   Huang, D ^a   Pain, A ^c   Saunders, J R ^b   Hobbs, M R ^d   Granger, D L ^d   Weinberg, J B ^e   Peshu, N ^f   Mwaikambo, E D ^g   Marsh, K ^f   Roberts, D J ^c   Anstey, N M ^b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF UTAH   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^g MUHIMBILI MEDICAL CENTRE   (Tanzania)

^h ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Immune regulation; Interleukin 12; Severe malaria; Th1 Th2

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12P40; NITRIC OXIDE;

ARTICLE; BRAIN MALARIA; CHILD; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MORTALITY; PRIORITY JOURNAL; RODENT; STATISTICAL ANALYSIS; TANZANIA; TH1 CELL; TH2 CELL;

ANIMALS; HUMANS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; KENYA; MALARIA, CEREBRAL; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; PLASMODIUM; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROTEIN SUBUNITS; TANZANIA;

RODENTIA;

EID: 19044393055     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6363909     Document Type: Article

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