Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit

Genes and Immunity

Volumn 1, Issue 8, 2000, Pages 515-520

  Huang, D ^a   Cancilla, M R ^a   Morahan, G ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Genetic variants; Interleukin 12; Polymorphisms

Indexed keywords

INTERLEUKIN 12;

ARTICLE; CHROMOSOME 5; CHROMOSOME MAP; GENETIC POLYMORPHISM; GENETICS; HUMAN; METHODOLOGY;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 5; HUMANS; INTERLEUKIN-12; POLYMORPHISM, GENETIC;

EID: 0034564291     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363720     Document Type: Article

References (17)

1. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann Rev Immunol 1995; 13: 251-276.
2. Gubler U, Chua AO, Schoenhaut DS et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 1991; 88: 4143-4147.
3. Gearing DP, Cosman D. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 1991; 66: 9-10.
4. Mattner F, Fischer S, Guckes S et al. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur J Immunol 1993; 23: 2202-2208.
5. de Jong R, Altare F, Haagen I et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 1998; 280: 1435-1438.
6. Warrington JA, Bengtsson U. High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis. Genomics 1994; 24: 395-398.
7. Johnson KJ, Sander T, Hicks AA et al. Confirmation of the localization of the human GABA-A receptor alpha-1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics 1992; 14: 745-748.
8. Hicks AA, Bailey MES, Riley BP et al. Further evidence for clustering of human GABA-A receptor subunit genes: localization of the alpha-6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. Genomics 1994; 20: 285-288.
9. Weissenbach J, Gyapay G, Dib C et al. A second generation linkage map of the human genome. Nature 1992; 359: 794-801.
10. Boehnke M, Lange K, Cox D. Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet 1991; 49: 1174-1188.
11. Ioannou PA, Amemiya CT, Garnes J et al. A new bacteriophage P1-derived vector for the propoagation of human DNA fragments. Nat Genet 1994; 6: 84-89.
12. Osoegawa K, Woon P, Zhao B et al. An improved approach for construction of Bacterial Artificial Chromosome Libraries. Genomics 1998; 52: 1-8.
13. Ma X, Chow JM, Gri G et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 1996; 183: 147-157.
14. Wolf SF, Temple PA, Kobayashi M et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991; 146: 3074-3081.
15. Hall, MA, McGlinn, E, Coakley, G et al. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 2000; 1: 219-224.
16. Tone Y, Thompson SA, Babik JM et al. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur J Immunol 1996; 26: 1222-27.
17. Zubiaga A, Belasco J, Greenberg M. The nonamer UUAU-UUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol 1995; 15: 2219-2230.