Chagas' disease susceptibility/resistance: Linkage disequilibrium analysis suggest epistasis between major histocompatibility complex and interleukin-10

Tissue Antigens

Volumn 64, Issue 1, 2004, Pages 18-24

  Moreno, M ^a   Silva, E L ^b   Ramirez L E ^b   Palacio, L G ^a   Rivera, D ^a   Arcos Burgos, M ^a,c  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b Medical School   (Brazil)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Chagas; Genetics; HLA; IL 10; IL 2; IL 2R ; IL 4; Interleukins; Linkage disequilibrium; MALD; MHC; NRAMP1; Trypanosoma cruzi

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MICROSATELLITE DNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN;

ARTICLE; CASE CONTROL STUDY; CHAGAS DISEASE; CONTROLLED STUDY; DISEASE RESISTANCE; EPISTASIS; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; POPULATION RESEARCH; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ALLELES; CASE-CONTROL STUDIES; CATION TRANSPORT PROTEINS; CHAGAS DISEASE; DOUBLE-BLIND METHOD; EPISTASIS, GENETIC; GENE FREQUENCY; HAPLOTYPES; HUMANS; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; LINKAGE DISEQUILIBRIUM; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROSATELLITE REPEATS; RECEPTORS, INTERLEUKIN-2;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 3042780037     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2004.00260.x     Document Type: Article

References (27)

1. Schofield CJ, Maudlin I. Trypanosomiasis control. Int J Parasitol 2001: 31: 614-9.
2. Williams-Blangero S, VandeBerg JL, Blangero J, Correa-Oliveira R. Genetic epidemiology of Trypanosoma cruzi infection and Chagas' disease. Front Biosci 2003: 8: e337-e345.
3. Cunha-Neto E, Duranti M, Gruber A et al. Autoimmunity in Chagas' disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci USA 1995: 92: 3541-5.
4. Cunha-Neto E, Kalil J. Autoimmunity in Chagas' heart disease. Rev Paul Med 1995: 113: 757-66.
5. Guhl F, Jaramillo C, Vallejo GA et al. Isolation of Trypanosoma cruzi DNA in 4,000-year-old mummified human tissue from northern Chile. Am J Phys Anthropol 1999: 108: 401-7.
6. Guhl F, Jaramillo C, Yockteng R, Vallejo GA, Cardenas-Arroyo F. Trypanosoma cruzi DNA in human mummies. Lancet 1997: 349: 1370.
7. Nieto A, Beraun Y, Collado MD et al. HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection. Tissue Antigens 2000: 55: 195-8.
8. Layrisse Z, Fernandez MT, Montagnani S et al. HLA-C (*) 03 is a risk factor for cardiomyopathy in Chagas' disease. Hum Immunol 2000: 61: 925-9.
9. Llop E, Rothhammer F, Acuna M, Apt W. HLA antigens in cardiomyopathic Chilean chagasics. Am J Hum Genet 1988: 43: 770-3.
10. Llop E, Rothhammer F, Acuna M, Apt W. HLA antigens in patients with Chagas cardiomyopathy: evidence favoring genetic protection against this disease. Rev Med Chil 1988: 116: 211-4.
11. Llop E, Rothhammer F, Acuna M, Apt W, Arribada A. HLA antigens in Chagas cardiomyopathy: new evidence based on a case-control study. Rev Med Chil 1991: 119: 633-6.
12. Acuna M, Rothhammer F, Moreno R et al. [Genetic evidence corroborates Negme's hypothesis about the greater mildness of American trypanosomiasis in Chile]. Rev Med Chil 1992: 120: 233-8.
13. Fernandez-Mestre MT, Layrisse Z, Montagnani S et al. Influence of the HLA class II polymorphism in chronic Chagas' disease. Parasite Immunol 1998: 20: 197-203.
14. Michailowsky V, Luhrs K, Rocha MO et al. Humoral and cellular immune responses to Trypanosoma cruzi-derived paraflagellar rod proteins in patients with Chagas' disease. Infect Immun 2003: 71: 3165-71.
15. Ramirez LE, Lages-Silva E, Pianetti GM et al. Prevention of transfusion-associated Chagas' disease by sterilization of Trypanosoma cruzi-infected blood with gentian violet, ascorbic acid, and light. Transfusion 1995: 35: 226-30.
16. Lages-Silva E, Crema E, Ramirez LE et al. Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism. Am J Trop Med Hyg 2001: 65: 435-41.
17. Lages-Silva E, Ramirez LE, Silva-Vergara ML, Chiari E. Chagasic meningoencephalitis in a patient with acquired immunodeficiency syndrome: diagnosis, follow-up, and genetic characterization of Trypanosoma cruzi. Clin Infect Dis 2002: 34: 118-23.
18. Ramirez LE, Lages-Silva E, Alvarenga-Franco F et al. High prevalence of Trypanosoma rangeli and Trypanosoma cruzi in opossums and triatomids in a formerly-endemic area of Chagas' disease in Southeast Brazil. Acta Trop 2002: 84: 189-98.
19. Cockerham CC, Weir BS. Estimation of inbreeding parameters in stratified populations. Ann Hum Genet 1986: 50: 271-81.
20. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992: 48: 361-72.
21. Slatkin M. Linkage disequilibrium in growing and stable populations. Genetics 1994: 137: 331-6.
22. McDonnell GV, Kirk CW, Hawkins SA, Graham CA. An evaluation of interleukin genes fails to identify clear susceptibility loci for multiple sclerosis. J Neurol Sci 2000: 176: 4-12.
23. Beraun Y, Nieto A, Collado MD, Gonzalez A, Martin J. Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease. Tissue Antigens 1998: 52: 81-3.
24. Colorado IA, Acquatella H, Catalioti F, Fernandez MT, Layrisse Z. HLA class II DRB1, DQB1, DPB1 polymorphism and cardiomyopathy due to Trypanosoma cruzi chronic infection. Hum Immunol 2000: 61: 320-5.
25. Michailowsky V, Silva NM, Rocha CD et al. Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection. Am J Pathol 2001: 159: 1723-33.
26. Talvani A, Ribeiro CS, Aliberti JC et al. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect 2000: 2: 851-66.
27. Calzada JE, Nieto A, Lopez-Nevot MA, Martin J. Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection. Tissue Antigens 2001: 57: 353-7.