Inhibition of PKB/Akt activity involved in apigenin-induced apoptosis in human gastric carcinoma cells

Chinese Science Bulletin

Volumn 52, Issue 16, 2007, Pages 2226-2232

  Yuan, Linhong ^a,b   Xia, Wei ^a   Zhao, Xiujuan ^a   Zhang, Xiaohua ^a   Zhang, Ling ^a   Wu, Kun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apigenin; Apoptosis; Gastric carcinoma; PKB Akt

Indexed keywords

EID: 34548065960     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-007-0342-6     Document Type: Article

References (46)

1. Parkin D M, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer, 1993, 54: 594-606
2. Parkin D M, Bray F I, Devesa S S. Cancer burden in the year 2000. The global picture. Eur J Cancer, 2001, 37: 54-66
3. Parkin D M. International variation. Oncogene, 2004, 23: 6329-6340
4. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer, 1992, 18: 1-29
5. Boone C W, Kelloff G J, Malone W E. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review. Cancer Res, 1990, 50: 2-9
6. Zhao B L. Antioxidant effects of green tea polyphenols. Chin Sci Bull, 2003, 48(4): 315-319
7. Duthie G, Crozier A. Plant-derived phenolic antioxidants. Curr Opin Clin Nutr Metab Care, 2000, 3: 447-451
8. Yin F, Giuliano A E, Law R E, et al. Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Res, 2001, 21: 413-420
9. Wang W, Heideman L, Chung C S, et al. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol Carcinog, 2000, 28: 102-110
10. Caltagirone S, Rossi C, Poggi A, et al. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer, 2000, 15: 595-600
11. Yin F, Giuliano A E, Law R E, et al. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid, 1999, 9: 369-376
12. Takahashi T, Kobori M, Shinmoto H, et al. Structure-activity relationships of flavonoids and the induction of granulocytic-or monocytic-differentiation in HL60 human myeloid leukemia cells. Biosci Biol Biochem, 1998, 62: 2199-2204
13. Czeczot H, Tudek B, Kusztelak J, et al. Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs. Mutat Res, 1990, 240: 209-216
14. Agullo G, Gamet-Payrastre L, Manenti S. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol, 1997, 53: 1649-1657
15. Kuo M L, Yang N C. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem Biophys Res Commun, 1995, 212: 767-775
16. Morino M, Tsuzuki T, Ishikawa Y. Specific regulation of HSPs in human tumor cell lines by flavonoids. In Vivo, 1997, 11: 265-270
17. Naasani I, Oh-Hashi F, Oh-Hara T. Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res, 2003, 63: 824-830
18. Birt D F, Mitchell D, Gold B, et al. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res, 1997, 17: 85-91
19. Franke T F, Kaplan D R, Cantley L C. PI3K: Downstream Aktion blocks apoptosis. Cell, 1997, 88: 435-437
20. Itoh N, Semba S, Ito M. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer, 2002, 94(12): 3127-3134
21. Kurose K, Zhou X P, Araki T. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression in primary epithelial ovarian carcinomas. Am J Pathol, 2001, 158: 2097-2106
22. Ringel M D, Hayre N, Saito J. Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res, 2001; 61: 6105-6111
23. Horiguchi A, Oya M, Uchid A. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol, 2003, 169: 710-713
24. Gang S, Gao L, Ou Y, et al. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med, 2005, 9: 59-71
25. Nicholson K M, Anderson N G. The Akt/PKB signaling pathway in human malignancy. Cell Signal, 2002, 14: 381-395
26. Yuan Z Q, Sun M, Feldman R I, et al. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene, 2000, 19: 2324-2330
27. Takagaki N, Sowa Y, Oki T, et al. Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway. Int J Oncol, 2005, 26: 185-189
28. Wang W, vanAlstyne P C, Irons K A, et al. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer, 2004, 48: 106-114
29. Jun C D, Choi B M, Kim H M, et al. Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages. J Immunol, 1995, 15: 6541-6547
30. Datta S R, Dudek H, Tao X. Akt phosphorylation of BAD couples survival signals to the cell intrinsic death machinery. Cell, 1997, 91: 231-241
31. Van Dross R, Xue Y, Knudson A, et al. The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. J Nutr, 2003, 133: 3800S-3804S
32. Wei H, Tye L, Bresnick E, et al. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res, 1990, 50: 499-502
33. Porter A G, Janicke R U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ, 1999, 6: 99-104
34. Geahlen R L, Koonchanok N M, Mclaughlin J L. Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds. J Nat Prod, 1989, 52: 982-986
35. Eiji O, Hideo B, Eriko T, et al. Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer, 2005, 117: 376-380
36. Nam S Y, Jung G A, Hur G C, et al. Upregulation of FLIP(s) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer Sci, 2003, 94: 1066-1073
37. Fang J, Xia C, Cao Z, et al. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J, 2005, 19: 342-353
38. Way T D, Kao M C, Lin J K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem, 2004, 279: 4479-4489
39. Ruiz P A, Haller D. Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J Nutr, 2006, 136: 664-671
40. Ying H, Yong C Z, Cao Y. Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. World J Gastroenterol, 2005, 11: 2224-2229
41. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol, 2004, 15: 177-182
42. Yasunobu K, Junzo K, Hiroaki I. Correlation between loss for PTEN expression and Akt phosphorylation in endometrial carcinoma. Clin Cancer Res, 2001, 7: 892-895
43. Mitsiades C S, Mitsiades N, Koutsilieris M. The Akt pathway: Molecular targets for anti-cancer drug development. Curr Cancer Drug Targets, 2004, 4: 235-256
44. Haruko S, Yoshio T, Tomokazu O, et al. The PI3-Kinase-Akt Pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-κB and Bad. J Am Soc Nephrol, 2003, 14: 1427-1434
45. Datta S R, Brunet A, Greenberg M E. Cellular survival: A play in three Akts. Genes Dev, 1999, 13: 2905-2927
46. Haslam R J, Kolde H B, Hemmings B A. Pleckstrin domain homology. Nature, 1993, 363: 309-310