Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction

Journal of Neuroscience

Volumn 27, Issue 33, 2007, Pages 8836-8844

  Wei, Qiang ^a   Hebda Bauer, Elaine K ^a   Pletsch, Amy ^a   Luo, Jie ^a   Hoversten, Mary T ^a   Osetek, Andrew J ^a   Evans, Simon J ^a,b   Watson, Stanley J ^a,b   Seasholtz, Audrey F ^a,c   Akil, Huda ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Aging; Cognitive; Glucocorticoid receptor; Hippocampus; Neuroendocrine; Stress

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUTAMATE RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; FOREBRAIN; GENETIC VARIABILITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; LIMBIC SYSTEM; MICROARRAY ANALYSIS; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TRANSGENIC MOUSE;

ADRENOCORTICOTROPIC HORMONE; AGING; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; CORTICOSTERONE; DEXAMETHASONE; GENE EXPRESSION REGULATION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROARRAY ANALYSIS; NEUROSECRETORY SYSTEMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSENCEPHALON; RECEPTORS, GLUCOCORTICOID; RECEPTORS, GLUTAMATE; RESTRAINT, PHYSICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRESS, PSYCHOLOGICAL;

EID: 34548065182     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0910-07.2007     Document Type: Article

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