Targeting the weak point of cancer by induction of necroptosis

Autophagy

Volumn 3, Issue 5, 2007, Pages 490-492

  Hu, Xun ^a   Han, Weidong ^a   Li, Ling ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Breast cancer resistant protein; Cancer; Chemotherapy; Drug resistance; Multidrug resistance associated protein 1; Necroptosis; P glycoprotein

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; EPIPODOPHYLLOTOXIN DERIVATIVE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BCL 2; PROTEIN BCL XL; SHIKONIN; TAXANE DERIVATIVE; VINCA ALKALOID;

APOPTOSIS; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; DRUG MECHANISM; DRUG SENSITIVITY; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; NECROPTOTIC SUSCEPTIBILITY; PROTEIN EXPRESSION; SHORT SURVEY; TARGET CELL;

VINCA;

EID: 34548064578     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.4592     Document Type: Short Survey

References (19)

1. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-99.
2. Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5:231-7.
3. Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 2004; 4:592-603.
4. Ricci MS, Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 2006; 11:342-57.
5. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205:275-92.
6. Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks. Oncogene 2004; 23:2934-49.
7. Hersey P, Zhang XD. Overcoming resistance of cancer cells to apoptosis. J Cell Physiol 2003; 196:9-18.
8. Gottesman MM, Tito F, Bates SE. Multidtug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2002; 1:48-58.
9. Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview. Adv Drug Deliv Rev 2003; 55:3-29.
10. Deeley RG, Westlake C, Cole SPC. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006; 86:849-99.
11. Ruefli AA, Tainton KM, Darcy PK, Smyth MJ, Johnstone RW. P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ 2002; 9:1266-72.
12. Johnstone RW, Cretney E, Smyth MJ. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999; 93:1075-85.
13. Lengauer C, Diaze Jr LA, Saha S. Cancer drug discovery through collaboration. Nat Rev Drug Discov 2005; 4:375-80.
14. Dancey JE, Chen HX. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat Rev Drug Discov 2006; 5:649-59.
15. Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo J, Hu X. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 2007; 6:1641-9.
16. Pan Q, Lu Q, Zhang K, Hu X. Dibenzocyclooctadiene lignans- a class of novel inhibitors of P-glycoprotein. Cancer Chemother Pharmacol 2006; 58:99-106.
17. Li L, Pan Q, Sun M, Lu Q, Hu X. Dibenzocyclooctadiene lignans- a class of novel inhibitors of multidrug resistance-associated protein 1. Life Sci 2007; 80:741-8.
18. Nakagawa M, Schneider E, Dixon KH, Horton J, Kelley K, Morrow C, Cowan KH. Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. Cancer Res 1992; 52:6175-81.
19. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1:112-9.