Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl

Chemical Research in Toxicology

Volumn 13, Issue 8, 2000, Pages 710-718

  Lin, P H ^a,b   Sangaiah, R ^a   Ranasinghe, A ^a   Upton, P B ^a   La, D K ^a   Gold, A ^a   Swenberg, J A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',5,5' TETRACHLOROBIPHENYL; BRAIN PROTEIN; CUMENE HYDROPEROXIDE; LIVER PROTEIN; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRACHLOROBIPHENYL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; HALF LIFE TIME; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RAT; STEADY STATE; XENOBIOTIC METABOLISM;

ANIMALS; BRAIN; CYSTEINE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; LIVER; MALE; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; PROTEIN BINDING; QUINONES; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0033845964     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000030f     Document Type: Article

References (36)

1. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs
2. Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260
3. Long-term effects of commercial and congeneric polychlorinated biphenyls on ethane production and malondialdehyde levels, indicators of in vivo lipid peroxidation
4. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB-induced oxidative stress in breast cancer
5. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment
6. Metabolic activation of PCBs to quinones: Reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase
7. The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays
8. Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices
9. The pharmacokinetics of 2,2',5,5'-tetrachlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl and its relationship to toxicity
10. 3H-2,5,2',5'-tetrachlorobiphenyl in rats
11. Metabolism in vitro of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450
12. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl
13. 32P-postlabeling technique
14. In vitro generation of a chemically reactive metabolite of 2,5,2',5'-tetrachlorobiphenyl by rhesus monkey liver microsomes
15. Measurement of adducts of benzoquinone with hemoglobin and albumin
16. Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats
17. Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts
18. Adducts of 2,2',5,5'-tetrachlorobiphenyl-derived ortho quinone with rat liver proteins after metabolic activation in vitro
19. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol
20. A new strategy for the synthesis of polychlorinated biphenyl metabolites
21. Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum
22. Synthesis of catechol and quinone derivatives of polychlorinated biphenyl
23. Degree of alkylation of macromolecules in vivo from variable exposure
24. Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers
25. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system
26. Cytochrome P-450-dependent formation of reactive oxygen radicals: Isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride
27. Cytochrome P450-catalyzed oxidation of halobenzene derivatives
28. Peroxidase-catalyzed oxidation of pentachlorophenol
29. Liver protein adducts of quinones and semiquinones from metabolic activation of pentachlorophenol
30. Non-arene oxide aromatic ring hydroxylation of 2,2',5,5'-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbital-induced rat liver microsomes
31. Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver
32. Direct evidence that an arene oxide is a metabolic intermediate of 2,2',5,5'-tetrachlorobiphenyl
33. Reactions of 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide with methionine, cysteine and glutathione in relation to the formation of methylthio metabolites of 2,2',5,5'-tetrachlorobiphenyl in the rat and mouse
34. DNA single strand breaks caused by 2,2',5,5'-tetrachlorobiphenyl and its metabolites
35. Toxicology of quinone-thioethers
36. Role of active oxygen species in DNA damage by pentachlorophenol metabolites