Anticarcinogenic responses in rodent cancer bioassays are not explained by random effects

Toxicological Sciences

Volumn 43, Issue 1, 1998, Pages 1-9

  Linkov, Igor ^b   Wilson, Richard ^b   Gray, George M ^a  

^a HARVARD CENTER FOR RISK ANALYSIS   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CLASSIFICATION; CANCER SURVIVAL; CARCINOGENICITY; FEMALE; MALE; MOUSE; NONHUMAN; RAT; RODENT; SIMULATION; WEIGHT REDUCTION;

ANIMALIA; RODENTIA;

EID: 0031833286     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2445     Document Type: Article

References (22)

1. Albert, R. E. (1985). The practical importance of antitumor bioassay responses in carcinogen risk assessment. Risk Anal. 5, 165.
2. Byrd, D., Crouch, E. A. C., and Wilson, R. (1991). Organ specificity of rodent tumor induction: A test of statistical and graphical methods by examination of tumor induction from ingestion of selected substances. In Risk Analysis (C. Zervos, Ed.), Plenum. New York.
3. Crouch, E. A. C., and Wilson, R. (1979). Interspecies comparison of carcinogenic potency. J. Toxicol. Environ. Health 5, 1095-1118.
4. Davies, T. S., and Monro, A. (1994). The rodent carcinogenicity bioassay produces a similar frequency of tumor increases and decreases: Implications for risk assessment. Reg. Toxicol. Pharmacol. 20, 281-301.
5. Gart. J. J., Chu, K. C., and Tarone, R. E. (1979). Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J. Natl. Cancer Inst. 62, 957-974.
6. Gray, G. M., Li, Ping, Shlyakhter, I., and Wilson, R. (1995). An empirical examination of factors influencing prediction of carcinogenic hazard across species. Reg. Toxicol. Pharmacol. 22, 283-291.
7. Haseman, J. K. (1983). Patterns of tumor incidence in two-year cancer bioassay feeding studies in Fischer 344 rats. Fundam. Appl. Toxicol. 3, 1-9.
8. Haseman, J. K. (1985). Evaluating the carcinogenic potential of a chemical that appears to both increase and decrease tumor incidences. Risk Anal. 5, 161-164.
9. Haseman, J. K. (1991). Value of historical controls in the interpretation of rodent tumor data. Drug Inf. J. 26, 199-200.
10. Haseman, J. K., Bourbina, J., and Eustis, S. L. (1994). Effects of individual housing and other experimental design factors on tumor incidence in B6C3F1 mice. Fundam. Appl. Toxicol. 23, 44-52.
11. Haseman, J. K. (1995). Data analysis: Statistical analysis and use of historical control data. Reg. Toxicol. Pharmacol. 21, 52-59.
12. Haseman, J. K., and Johnson, F. M. (1996). Analysis of national toxicology program rodent bioassay data for anticarcinogenic effects. Mutat. Res. 350, 131-141.
13. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, D. A., Dittenberger, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Bernard, S. D., Hummel, R. A., and Humiston, C. G. (1978). Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol. 46, 279-303.
14. Linkov, I., Wilson, R., and Gray, G. M. (1998). Weight and survival depression in rodent bioassays with and without tumor decreases. Toxicol. Sci. 43, 10-18.
15. Portier, C., and Hoel, D. (1983). Optimal design of the chronic animal bioassay. J. Toxicol. Environ. Health 12, 1-19.
16. Rosner. B. (1995). Fundamentals of Biostatistics. Duxbury Press, Wadsworth Publishing Company, Belmont.
17. Salsburg, D. (1983). The lifetime feeding study in mice and rats-An examination of its validity as a bioassay for human carcinogens. Fundam. Appl. Toxicol. 3, 63-67.
18. Salsburg, D. (1989). Does everything "cause" cancer: An alternative interpretation of the "carcinogenesis" bioassay. Fundam. Appl. Toxicol. 13, 351-358.
19. Schweder, T., and Spjøtvoll, E. (1982). Plots of p-values to evaluate many tests simultaneously. Biometrika 69, 493-502.
20. Tarone, R. E. (1982). The use of historical control information in testing for a trend in proportions. Biometrics 38, 215-220.
21. Weinberg, A. M., and Storer, J. B. (1985). Ambiguous carcinogens and their regulation. Risk Anal. 5, 151-156.
22. Young, S. S., and Gries, C. L. (1984). Exploration of the negative correlation between proliferative hepatocellular lesions and lymphoma in rats and mice. Fundam. Appl. Toxicol. 4, 632-640.