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Volumn 62, Issue 1, 2001, Pages 36-45

Hepatocellular iron accumulation and increased cell proliferation in polychlorinated biphenyl-exposed sprague-dawley rats and the development of hepatocarcinogenesis

(2) Whysner, J a Wang, C X a

a AMERICAN HEALTH FOUNDATION (United States)

Author keywords

Aroclor; Cancer mechanism; Carcinogenesis; Cell proliferation; Iron accumulation; Liver cancer; Polychlorinated biphenyls; Tumor promotion

Indexed keywords

AROCLOR 1254; AROCLOR 1260; CYCLINE; GLUTATHIONE TRANSFERASE; IRON; POLYCHLORINATED BIPHENYL DERIVATIVE; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION FUNCTION; DOSE RESPONSE; EVALUATION; EXPOSURE; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCIDENCE; KUPFFER CELL; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; MALE; NONHUMAN; OXIDATION; PLACENTA; RAT; RODENT; STATISTICAL ANALYSIS; TISSUE SECTION;

ADENOCARCINOMA; ANIMALS; AROCLOR 1254; CARCINOGENICITY TESTS; CARCINOGENS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; IRON; KUPFFER CELLS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

ANIMALIA; RODENTIA;

EID: 0034952523 PISSN: 10966080 EISSN: None Source Type: Journal
DOI: 10.1093/toxsci/62.1.36 Document Type: Article

Times cited : (35)

References (49)

1
- 0026556499
- Induction of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by co-planar polychlorinated biphenyl congeners
- (1992) Biochem. J. , vol.281 , pp. 539-543
- Aoki, Y.¹ Satoh, K.² Sato, K.³ Suzuki, K.T.⁴

2
- 0004696009
- PCB effects on epigenetic carcinogenic processes
- (in press) (L. W. Robertson and L. G. Hanson, Eds.).
- Recent Advances in the Environmental and Health Effects of PCBs
- Brown J.F., Jr.¹ Fish, K.M.² Mayes, B.A.³ Silkworth, J.B.⁴ Hamilton, S.B.⁵ Whysner, J.⁶

3
- 0004692364
- An Assessment of the Chronic Toxicity and Oncogenicity of Aroclor-1016, Aroclor-1242, Aroclor-1254, and Aroclor-1260 Administered in Diet to Rats: Chronic Toxicity and Oncogenicity Report. Batelle, Columbus, OH.
- (1996)
- Brunner, J.M.¹ Sullivan, T.M.² Singer, A.W.³ Ryan, M.J.⁴ Toft, J.D.⁵ Menton, R.S.⁶ Graves, S.W.⁷ Peters, A.C.⁸

4
- 0029549607
- Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens
- (1995) J. Environ. Pathol. Toxicol. Oncol. , vol.14 , pp. 83-99
- Chen, Z.Y.¹ White, C.C.² He, C.-Y.³ Liu, Y.-F.⁴ Eaton, D.L.⁵

5
- 0020361220
- Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver
- (1982) Carcinogenesis , vol.3 , pp. 1449-1453
- Deml, E.¹ Oesterle, D.²

6
- 0023272622
- Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay
- (1987) Arch. Toxicol. , vol.60 , pp. 209-211
- Deml, E.¹ Oesterle, D.²

7
- 0009663357
- A multiple comparisons procedure for comparing several treatments, with a control
- (1955) J. Am. Stat. Assoc. , vol.50 , pp. 1096-1121
- Dunnett, C.W.¹

8
- 0022825042
- Oncogenicity of hexachlorobenzene
- (C. R. Morris, and J. R. P. Cabral, Eds.), IARC Scientific Publication, Lyon.
- (1986) Hexachlorobenzene: Proceedings of an International Symposium , vol.7 , pp. 417-423
- Erturk, E.¹ Lambrecht, R.W.² Peters, H.A.³ Cripps, D.J.⁴ Gocmen, A.⁵ Morris, C.R.⁶ Bryan, G.T.⁷

9
- 0026499853
- Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254
- (1992) Carcinogenesis , vol.13 , pp. 247-250
- Faux, S.P.¹ Francis, J.E.² Smith, A.G.³ Chipman, J.K.⁴

10
- 0026783501
- Relative liver tumor promoting activity of some polychlrorinated dibenzo-p-dioxin, dibenzofuran and biphenyl congeners in female rats
- (1992) Chemosphere , vol.25 , pp. 169-172
- Flodström, S.¹ Ahlborg, U.G.²

11
- 0031430858
- Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of Porphyria Cutanea Tarda
- (1997) Toxicol. Appl. Pharmacol. , vol.147 , pp. 289-299
- Franklin, M.R.¹ Phillips, J.D.² Kushner, J.P.³

12
- 0015971699
- Experimental hepatic porphyria induced by polychlorinated biphenyls
- (1974) Toxicol. Appl. Pharmacol. , vol.27 , pp. 437-448
- Goldstein, J.A.¹ Hickman, P.² Jue, D.L.³

13
- 0026648674
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
- (1992) J. Cell Biol. , vol.119 , pp. 493-501
- Gravrieli, Y.¹ Sherm, Y.² Ben-Sasson, S.A.³

14
- 0003536299
- 3rd ed., Oxford University Press, Oxford U.K.
- (1999) Free Radicals in Biology and Medicine , pp. 172
- Halliwell, B.¹ Gutteridge, J.M.C.²

15
- 0030766252
- Assessment of chronic toxicity and carcinogenicity in rats of Wingstay 100, a rubber antioxidant/antiozonant
- (1997) Exp. Toxicol. Pathol. , vol.49 , pp. 153-165
- Iatropoulos, M.J.¹ Williams, G.M.² Wang, C.-X.³ Brunnemann, K.D.⁴ Leber, A.P.⁵

16
- 0026727139
- Pathological markers for non-genotoxic agent-associated carcinogenesis
- (1992) Toxicol. Lett. , vol.64-65 , pp. 613-620
- Ito, N.¹ Hasegawa, R.² Imaida, K.³ Masui, T.⁴ Takahashi, S.⁵ Shirai, T.⁶

17
- 0033046665
- Mortality in male and female capacitor workers exposed to polychlorinated biphenyls
- (1999) J. Occup. Environ. Med. , vol.41 , pp. 161-171
- Kimbrough, R.D.¹ Doemland, M.L.² LeVois, M.E.³

18
- 0016587944
- Induction of liver tumors in Sherman-strain female rats by polychlorinated biphenyl Aroclor 1260
- (1975) J. Natl. Cancer Inst. , vol.55 , pp. 1453-1459
- Kimbrough, R.D.¹ Squire, R.A.² Linder, R.E.³ Strandberg, J.D.⁴ Montali, R.J.⁵ Burse, V.W.⁶

19
- 0017737665
- Subacute toxicity of hexachlorobenzene in the rat
- (1977) Toxicol. Appl. Pharmacol. , vol.40 , pp. 529-549
- Kuiper-Goodman, T.¹ Grant, D.L.² Moodie, C.A.³ Korsrud, G.O.⁴ Munro, I.C.⁵

20
- 0004662753
- Diagnostic Liver Pathology, Mosby, St. Louis.
- (1994) , pp. 237-249
- Lee, R.G.¹

21
- 0023037399
- An animal model of iron overload and its application to study hepatic ferritin iron mobilization by chelators
- (1986) Biochem. Pharmacol. , vol.35 , pp. 3669-3678
- Longueville, A.¹ Crichton, R.R.²

22
- 0030040360
- Modulation of iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254)
- (1996) Toxicol. Appl. Pharmacol. , vol.136 , pp. 79-86
- Madra, S.¹ Mann, F.² Francis, J.E.³ Manson, M.M.⁴ Smith, A.G.⁵

23
- 0028890618
- Molecular regulation of heme biosynthesis in higher vertebrates
- (1995) Prog. Nucleic Acid Res. Mol. Biol. , vol.51 , pp. 1-51
- May, B.K.¹ Dogra, S.C.² Sadlon, T.J.³ Bhasker, C.R.⁴ Cox, T.C.⁵ Bottomley, S.S.⁶

24
- 15644382106
- Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260
- (1998) Toxicol. Sci. , vol.41 , pp. 62-76
- Mayes, B.A.¹ McConnell, E.E.² Neal, B.H.³ Brunner, M.J.⁴ Hamilton, S.B.⁵ Sullivan, T.M.⁶ Peters, A.C.⁷ Ryan, M.J.⁸ Toft, J.D.⁹ Singer, A.W.¹⁰ Brown J.F., Jr.¹¹ Menton, R.G.¹² Moore, J.A.¹³

25
- 0023215479
- Single GST-P-positive liver cells-putative initiated hepatocytes
- (1987) Carcinogenesis , vol.8 , pp. 483-486
- Moore, M.A.¹ Nakagawa, K.² Satoh, K.³ Ishikawa, T.⁴ Sato, K.⁵

26
- 0004665251
- NCI Bioassay of Aroclor®, 1254 for possible carcinogenicity. Report
- (1978) , vol.346 , pp. 1-62

27
- 0021893089
- Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat
- (1985) Environ. Health Perspect. , vol.60 , pp. 97-105
- Norback, D.H.¹ Weltman, R.H.²

28
- 0000073291
- Human hereditary porphyrias
- (J. Bircher, J.-P. Benhamou, N. McIntre, M. Rizzetto and J. Rodés, Eds.), Oxford University Press, New York.
- (1999) Oxford Textbook of Clinical Hepatology , vol.2 , pp. 1424-1429
- Nordmann, Y.¹

29
- 0023630781
- Turkish epidemic hexachloronbenzene porphyria: A 30-year study
- (1987) Ann. NY Acad. Sci. , vol.514 , pp. 183-190
- Peters, H.¹ Cripps, D.² Gocmen, A.³ Bryan, G.⁴ Erturk, E.⁵ Morris, C.⁶

30
- 0022992721
- Effects of tumor promoters, genotoxic carcinogens, and hepatocytotoxins on mouse hepatocyte intercellular communications
- (1986) Cell Biol. Toxicol. , vol.2 , pp. 469-483
- Ruch, R.J.¹ Klaunig, J.E.²

31
- 0024492933
- Polychlorinated biphenyls (PCBs): Mutagenicity and carcinogenicity
- (1989) Mutat. Res. , vol.220 , pp. 31-47
- Safe, S.¹

32
- 0023875771
- Glutathione S-transferases and hepatocarcinogenesis
- (Gann)
- (1988) Jpn. J. Cancer Res. , vol.79 , pp. 556-572
- Sato, K.¹

33
- 0021191445
- Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats
- (1984) Toxicol. Appl. Pharmacol. , vol.75 , pp. 278-288
- Schaeffer, E.¹ Greim, H.² Goessner, W.³

34
- 0029127380
- The difference in liver pathology between sporadic and familial forms of porphyria cutanea tarda: The role of iron
- (1995) J. Hepatol. , vol.23 , pp. 259-267
- Siersema, P.D.¹ Rademakers, L.H.² Cleton, M.I.³ ten Kate, F.J.⁴ de Bruijn, W.C.⁵ Marx, J.J.⁶ Wilson, J.H.⁷

35
- 0025172709
- Chlorinated biphenyls induce cytochrome P4501A2 and uroporphyrin accumulation in cultures of mouse hepatocytes
- (2000) Arch. Biochem. Biophys. , vol.281 , pp. 225-232
- Sinclair, P.R.¹ Gorman, N.² Bement, W.J.³ Sinclair, J.F.⁴

36
- 0029616538
- Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals
- (1995) Toxicol. Lett. , vol.82-83 , pp. 945-950
- Smith, A.G.¹ Carthew, P.² Clothier, B.³ Constantin, D.⁴ Francis, J.E.⁵ Madra, S.⁶

37
- 0025110861
- Oxidative injury mediated by the hepatic cytochrome P-450 system in conjunction with cellular iron. Effects on the pathway of heame biosynthesis
- (1990) Xenobiotica , vol.20 , pp. 865-877
- Smith, A.G.¹ De Matteis, F.²

38
- 0025014815
- Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah-responsive C57BL/10ScSn mice
- (1990) Carcinogenesis , vol.11 , pp. 437-444
- Smith, A.G.¹ Francis, J.E.² Carthew, P.³

39
- 0022362367
- Hepatocarcinogenicity of hexachlorobenzene in rats and the sex difference in hepatic iron status and development of porphyria
- (1985) Carcinogenesis , vol.6 , pp. 631-636
- Smith, A.G.¹ Francis, J.E.² Dinsdale, D.³ Manson, M.M.⁴ Cabral, J.R.P.⁵

40
- 0004699259
- Chemical porphyria
- Topics in Environmental Health. Halogeneted Biphenyls, Terphenyls, Naphtalenes, Dibenzodioxins andRelatedProducts (Kimbrough, Ed.), Elsevier, North Holland.
- (1980) , vol.4 , pp. 191-239
- Strik, J.J.¹ Debets, F.M.²

41
- 0025338776
- Effects of intercellular communication in human keratinocytes and liver-derived cells of polychlorinated biphenyl congeners with differing in vivo promotion activities
- (1990) Carcinogenesis , vol.11 , pp. 921-926
- Swierenga, S.H.H.¹ Yamasaki, H.² Piccoli, C.³ Robertson, L.⁴ Bourgon, L.⁵ Marceau, N.⁶ Fitzgerald, D.J.⁷

42
- 0022457184
- Lysosomes, but not mitochondria, accumulate iron and porphyrins in porphyria induced by hexachlorobenzene
- (1986) Biochem. J. , vol.235 , pp. 671-675
- Tangeras, A.¹

43
- 0031807402
- Enhanced regional expression of glutathione S-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria
- (1998) Toxicol. Appl. Pharmacol. , vol.150 , pp. 22-31
- Thomas, R.S.¹ Gustafson, D.L.² Ramsdell, H.S.³ El-Masri, H.A.⁴ Benjamin, S.A.⁵ Yang, R.S.H.⁶

44
- 0015758982
- Sex and age differences in the hemosiderin content of rat liver
- (1973) Biochim. Biophys. Acta , vol.328 , pp. 365-372
- Vidnes, A.¹ Helgeland, L.²

45
- 0031882364
- 32 P-postlabeling assay
- (1998) Toxicol. Appl. Pharmacol. , vol.148 , pp. 14-23
- Whysner, J.¹ Montandon, F.² McClain, M.³ Downing, J.⁴ Verna, L.K.⁵ Steward III, R.E.⁶ Williams, G.M.⁷

46
- 0032618379
- Chemically induced preneoplastic lesions in rodents as indicators of carcinogenic activity
- The Use of Short- and Medium-term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazards Evaluation (D.B. McGregor, J. M. Rice, and S. Venitt, Eds.), IARC Scientific Publications. IARC, Lyon.
- (1999) , vol.146 , pp. 185-202
- Williams, G.M.¹

47
- 0023928083
- Altered growth control of rat hepatocytes after treatment with 3,4,3′,4′-tetrachlorobiphenyl in vivo and in vitro
- (1988) Carcinogenesis , vol.9 , pp. 919-924
- Wölfle, D.¹ Münzel, P.² Fischer, G.³ Bock, K.W.⁴

48
- 0002958252
- The liver and iron
- (I. M. Arias, J. L.Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz, Eds.), Raven Press, New York.
- (1994) The Liver: Biology and Pathology , pp. 597-617
- Young, S.P.¹ Aisen, P.²

49
- 0004252445
- 2nd ed., Prentice-Hall, New Jersey
- (1984) Biostatistical Analysis , pp. 292-295
- Zar, J.H.¹

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