The characterization of paclitaxel-loaded microspheres manufactured from blends of poly(lactic-co-glycolic acid) (PLGA) and low molecular weight diblock copolymers

International Journal of Pharmaceutics

Volumn 342, Issue 1-2, 2007, Pages 6-17

  Jackson, John K ^a   Hung, Tawny ^a   Letchford, Kevin ^a   Burt, Helen M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Diblock copolymers; Microspheres; Paclitaxel; PLGA

Indexed keywords

COPOLYMER; MACROGOL; MICROSPHERE; PACLITAXEL; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIC ACID;

ARTICLE; BIOCOMPATIBILITY; DIFFERENTIAL SCANNING CALORIMETRY; ENCAPSULATION; GEL PERMEATION CHROMATOGRAPHY; GLASS TRANSITION TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LEUKOCYTE ACTIVATION; MISCIBILITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIFFERENTIAL THERMAL ANALYSIS; DRUG COMPOUNDING; EXCIPIENTS; LACTIC ACID; LUMINESCENCE; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; NEUTROPHILS; PACLITAXEL; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; SURFACE PROPERTIES;

EID: 34547903625     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.04.022     Document Type: Article

References (41)

1. Balakrishnan B., Kumar D.S., Yoshida Y., and Jayakrishnan A. Chemical modification of poly(vinyl chloride) resin using poly(ethylene glycol) to improve blood compatibility. Biomaterials 26 (2005) 3941-3951
2. Brigger I., Morizet J., Aubert G., Chacun H., Terrier-Lacombe M.J., Couvreur P., and Vassal G. Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting. J. Pharmacol. Exp. Ther. 303 (2002) 928-936
3. Burt H.M., Jackson J.K., Bains S.K., Liggins R.T., Oktaba A.M.C., Arsenault A.C., and Hunter W.C. Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d,l-lactic acid). Cancer Lett. 88 (1995) 73-79
4. Burt H.M., and Hunter W.L. Drug eluting stends: a multidisciplinary success story. Adv. Drug Rev. 58 (2006) 350-357
5. Byun J.W., Kim J.U., Chung W.J., and Lee Y.S. Surface-grafted polystyrene beads with comb-like poly (ethylene glycol) chains: preparation and biological application. Macromol. Biosci. 4 (2004) 512-519
6. Castellanos I.J., Flores G., and Griebenow K. Effect of the molecular weight of poly(ethylene glycol) used as emulsifier on alpha-chymotrypsin stability upon encapsulation in PLGA microspheres. J. Pharm. Pharmacol. 57 (2005) 1261-1269
7. Crosasso P., Ceruti M., Brusa P., Arpicco S., Dosio F., and Cattel L. Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes. J. Control. Release 63 (2000) 19-30
8. Demetrick J.S., Liggins R.T., Machan L., Davis N.L., Burt H.M., and Hunter W.L. The development of a novel intraperitoneal tumor seeding prophylactic. Am. J. Surg. 173 (1997) 403-406
9. Deng X., Zhou S., Li X., Zhao J., and Yuan M. In vitro degradation and release profiles for poly-dl-lactide-poly(ethylene glycol) microspheres containing human serum albumin. J. Control. Release 71 (2001) 165-173
10. Dordunoo S.K., Jackson J.K., Arsenault L.A., Oktaba A.M.C., Hunter W.C., and Burt H.M. Taxol encapsulation in poly(caprolactone) microspheres. Cancer Chemo. Pharmacol. 36 (1995) 279-282
11. Faraasen S., Voros J., Csucs G., Textor M., Merkle H.P., and Walter E. Ligand specific targeting of microspheres to phagocytes by surface modification with poly(l-lysine)-grafted poly(ethylene glycol) conjugate. Pharm. Res. 20 (2003) 237-246
12. Fonseca C., Simoes S., and Gaspar R. Paclitaxel-loaded PLGA nanoparticles: preparation physicochemical characterization and in vitro anti-tumoral activity. J. Control. Release 83 (2002) 273-286
13. Gorbet M.B., and Sefton M.V. Complement inhibition reduces material-induced leukocyte activation with PEG modified polystyrene beads (Tentagel) but not polystyrene beads. J. Biomed. Mater. Res. 74A (2005) 511-522
14. Gupte A., and Ciftci K. Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres. Int. J. Pharm. 276 (2004) 93-106
15. Huizing M.T., Misser V.H.S., Pieters R.C., Huinink W.W.T., Vencor C.H.N., Vermorken J.B., Pinedo H.M., and Beijnen J.H. Taxanes-a new class of anticancer agents. Cancer Invest. 4 (1995) 381-404
16. Jackson J.K., Springate C.M.K., Hunter W.L., and Burt H.M. Neutrophil activation by plasma opsonized polymeric microspheres: inhibitory effect of Pluronic F127. Biomaterials 21 (2000) 1483-1491
17. Jackson J.K., Gleave M.E., Yago V., Beraldi E., Hunter W.L., and Burt H.M. The suppression of human prostate tumor growth in mice by the intra-tumoral injection of a slow release polymeric paste formulation of paclitaxel. Cancer Res. 60 (2000) 4146-4151
18. Jackson J.K., Letchford K., Babiuk K.A., Machan L., Signore P., Hunter W.L., Wang K., and Burt H.M. Characterization of perivascular poly(lactic-co-glycolic acid) films containing paclitaxel. Int. J. Pharm. 283 (2004) 97-109
19. Jackson J.K., Zhang X., Llewellen S., Hunter W.L., and Burt H.M. The characterization of novel polymeric paste formulations for intratumoral delivery. Int. J. Pharm. 270 (2004) 185-198
20. Jiang W., and Schwendeman S.P. Stabilization and controlled release of bovine serum albumin encapsulated in poly (d,l-lactide) and poly(ethylene glycol) microsphere blends. Pharm. Res. 18 (2001) 878-885
21. Lapidus R.G., Dang W., Rosen D.M., Gady A.M., Zabelinka Y., O'Meally R., DeWeese T.L., and Denmeade S.R. Anti-tumor effect of combination therapy with intratumoral controlled-release paclitaxel (PACLIMER microspheres) and radiation. Prostate 58 (2004) 291-298
22. Letchford K., Zastre J., Liggins R., and Burt H.M. Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers. Colloids Surf. B: Biointerfaces 35 (2004) 81-91
23. Liggins R.T., D'Amours S., Demetrick J.S., Machan L.S., and Burt H.M. Paclitaxel loaded poly(l-lactic acid) microspheres for the prevention of intraperitoneal carcinomatosis after a surgical repair and tumor cell spill. Biomaterials 21 (2000) 1959-1969
24. Liggins R.T., and Burt H.M. Paclitaxel loaded poly(l-lactic acid) microspheres: properties of microspheres made with low molecular weight polymers. Int. J. Pharm. 222 (2001) 19-33
25. Liggins R.T., Cruz T., Min W., Liang L., Hunter W.L., and Burt H.M. Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits. Inflamm. Res. 53 (2004) 363-372
26. Liggins R.T., and Burt H.M. Paclitaxel-loaded poly (l-lactic acid) microspheres 3: blending low and high molecular weight polymers to control morphology and drug release. Int. J. Pharm. 282 (2004) 61-71
27. Liu Y., and Deng X. Influences of preparation conditions on particle size and DNA-loading efficiency for poly(dl-lactic acid-polyethylene glycol) microspheres entrapping free DNA. J. Control. Release 83 (2002) 147-155
28. Meese T.M., Hu Y., Nowak R.W., and Marra K.G. Surface studies of coated polymer microspheres and protein release from tissue-engineered scaffolds. J. Biomater. Sci. Polym. Ed. 13 (2002) 141-151
29. Mu L., and Feng S.S. Fabrication, characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers. J. Control. Release 76 (2001) 239-254
30. Muller M., Voros J., Csucs G., Walter E., Danuser G., Merkle H.P., Spencer N.D., and Textor M. Surface modification of PLGA microspheres. J. Biomed. Mater. Res. 66A (2003) 55-61
31. Norris D.A., Puri N., Labib M.E., and Sinko P.J. Determining the absolute surface hydrophobicity of microparticulates using thin layer wiking. J. Control. Release 59 (1999) 173-185
32. Onetto N., Canetta R., Winograd B., Catane R., Dougan M., Grechko J., Burroughs J., and Rozencweig M. Overview of taxol safety. J. Natl. Cancer Inst. Monogr. 15 (1993) 131-139
33. Ruan G., and Feng S.S. Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. Biomaterials 24 (2003) 5037-5044
34. Signore P.E., Machan L.S., Jackson J.K., Burt H.M., Bromley P., Wilson J.E., and McManus B.M. Complete inhibition of intimal hyperplasia by perivascular delivery of paclitaxel in balloon-injured rat carotid arteries. J. Vasc. Interv. Radiol. 12 (2001) 70-88
35. Stolnik S., Daudali B., Arien A., Whetstone J., Heald C.R., Garnett M.C., Davis S.S., and Ilium L. The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers. Biochim. Biophys. Acta 1514 (2001) 261-279
36. Torchilin V.P. Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res. 24 (2007) 1-16
37. Wang J., Ng C.W., Win K.Y., Shoemakers P., Lee T.K., Feng S.S., and Wang C.H. Release of paclitaxel from polylactide-co-glycolide (PLGA) microparticles and discs under irradiation. J. Microencapsul. 20 (2003) 317-327
38. Winternitz C.I., Jackson J.K., Oktaba A.M., and Burt H.M. Development of a polymeric surgical paste formulation for taxol. Pharm. Res. 13 (1996) 368-375
39. Zhang X., Jackson J.K., and Burt H.M. Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int. J. Pharm. 132 (1996) 195-206
40. Zhou S., Deng X., and Yang H. Biodegradable poly(ε-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials 24 (2003) 3563-3670
41. Zielhuis S.W., Nijsen J.F.W., Figueredo R., Feddes B., Vredenberg A.M., van het Schip A.D., and Hennink W.E. Surface characteristics of holmium-loaded poly(l-lactic acid) microspheres. Biomaterials 26 (2005) 925-932