The characterization of novel polymeric paste formulations for intratumoral delivery

International Journal of Pharmaceutics

Volumn 270, Issue 1-2, 2004, Pages 185-198

  Jackson, John K ^a   Zhang, Xichen ^b   Llewellen, Stevyn ^a   Hunter, William L ^c   Burt, Helen M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b AlleCure Corporation   (United States)

^c Angiotech Pharmaceuticals Inc   (Canada)

Author keywords

Intratumoral; Paclitaxel; Polymeric paste

Indexed keywords

ANTINEOPLASTIC AGENT; COPOLYMER; METHOXYPOLYETHYLENE GLYCOL; PACLITAXEL; POLY(LACTIDE CO CAPROLACTONE) BLOCK POLYETHYLENE GLYCOL BLOCK POLY(LACTIDE CO CAPROLACTONE); UNCLASSIFIED DRUG;

AGITATION; ARTICLE; CANCER; CONTROLLED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG RELEASE; FRAGMENTATION REACTION; GEL PERMEATION CHROMATOGRAPHY; MISCIBILITY; MOLECULAR WEIGHT; NEEDLE; PASTE; PELLET EXTRUSION; PRIORITY JOURNAL;

EID: 0346391121     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.10.010     Document Type: Article

References (25)

1. Brem H., Mahaley M.S., Vick N.A., Black K., Schold S.C., Burger P.C., Friedman A.H., Ciric I.S., Eller T.W., Cozzens J.W., Kenealy J.N. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J. Neurosurg. 74:1991;441-446.
2. Brown J.M., Giaccia A.J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 58:1998;1408-1416.
3. Burt H.M., Zhang X., Toleikis P., Embree L., Hunter W.L. Development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Coll. Surfaces B: Interfaces. 16:1999;161-171.
4. Chenite A., Chaput C., Wang D., Combes C., Buschmann M.D., Hoemann C.D., Leroux J.C., Atkinson B.L., Binette F., Selmani A. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials. 21:2000;2155-2161.
5. Dordunoo S.K., Oktaba A.M.C., Hunter W., Min W., Cruz T., Burt H.M. Release of taxol from poly(ε-caprolactone) pastes: effect of water-soluble additives. J. Controlled Rel. 44:1997;87-94.
6. Egilmez N.K., Jong Y.S., Sabel M.S., Jacob J.S., Mathiowitz E., Bankert R.B. In situ tumor vaccination with interleukin-12 encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity. Cancer Res. 60:2000;3832-3837.
7. Eliaz R.E., Kost J. Characterization of a polymeric PLGA injectable implant delivery system for the controlled release of proteins. J. Biomed. Mater. Res. 50:2000;388-398.
8. Fung L.K., Saltzman W.M. Polymeric implants for cancer chemotherapy. Adv. Drug Deliv. Rev. 26:1997;209-230.
9. Hanes J., Sills A., Zhao Z., Suh K.W., Tyler B., DiMeco F., Brat D.J., Choti M.A., Leong K.W., Pardoll D.M., Brem H. Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors. Pharm. Res. 18:2001;899-906.
10. Harper E., Dang W., Lapidus R.G., Garver R.I. Jr. Enhanced efficacy of a novel controlled release paclitaxel formulation (Paclimer delivery system) for local-regional therapy of lung cancer tumor nodules in mice. Clin. Cancer Res. 12:1999;4242-4248.
11. Hunter W.L., Burt H.M., Machan L. Local delivery of chemotherapy: a supplement to existing cancer treatments. A case for surgical pastes and coated stents. Adv. Drug Deliv. Rev. 26:1997;199-207.
12. Jackson J.K., Gleave M.E., Yago V., Beraldi E., Hunter W.L., Burt H.M. The suppression of human prostate tumor growth in mice by the intratumoral injection of a slow release polymeric paste formulation of paclitaxel. Cancer Res. 60:2000;4146-4151.
13. Jain, R.K., 1994. Barriers to Drug Delivery in Solid Tumors. Scientific American, July, pp. 42-49.
14. Jeong B., Bae Y.H., Lee D.S., Kim S.W. Biodegradable block copolymers as injectable drug delivery systems. Nature. 388:1997;860-862.
15. Jeong B., Bae Y.H., Kim S.W. Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J. Controlled Rel. 63:2000;155-163.
16. Kim Y.J., Choi S., Koh J.J., Lee M., Ko K.S., Kim S.W. Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm. Res. 18:2001;548-550.
17. Liggins R.T., Burt H.M. Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. Adv. Drug Delivery Rev. 54:2002;191-202.
18. Nichols M.E., Richardson R.E. The origin of multiple melting endotherms in the thermal analysis of polymers. J. Polymer Sci. Part B: Polymer Phys. 30:1992;305-307.
19. Nishi T., Wang T. Melting point depression and kinetic effects of cooling on crystallization in poly(vinylidene fluoride)-poly(methyl methacrylate) mixtures. Macromolecules. 8:1975;909-915.
20. Rosen, S.L., 1993. Fundamental Principles of Polymeric Materials, 2nd ed. Wiley, New York.
21. Shively M.L., Coonts B.A., Renner W.D., Southard J.L., Bennett A.T. Physico-chemical characterization of a polymeric injectable implant delivery system. J. Controlled Rel. 33:1995;237-243.
22. Walter K.A., Mitchell A.C., Gur A., Tyler B., Hilton J., Colvin O.M., Burger P.C., Domb A., Brem H. Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma. Cancer Res. 54:1994;2207-2212.
23. Winternitz C.I., Jackson J.K., Oktaba A.M., Burt H.M. Development of a polymeric surgical paste formulation of taxol. Pharm. Res. 13:1996;368-375.
24. Zentner G.M., Rathi R., Shih C., McRea J.C., Seo M.-H., Oh H., Rhee B.G., Mestecky J., Moldoveanu Z., Morgan M., Weitman S. Biodegradable block copolymers for delivery of proteins and water insoluble drugs. J. Controlled Rel. 72:2001;203-215.
25. Zhang X., Jackson J.K., Wong W., Min W., Cruz T., Hunter W.L., Burt H.M. Development of biodegradable polymeric paste formulations for taxol: an in vitro and in vivo study. Int. J. Pharmaceutics. 137:1996;199-208.