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Volumn 16, Issue 5, 2007, Pages 451-458

The transient receptor potential vanilloid-responsive 1 and 4 cation channels: Role in neuronal osmosensing and renal physiology

Author keywords

Hypernatremia; Hypertension; Hyponatremia; Hypotension; Kidney

Indexed keywords

CATION CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL VANILLOID RESPONSIVE 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL VANILLOID RESPONSIVE 4; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

EID: 34547864302     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32821f6060     Document Type: Review
Times cited : (22)

References (92)
  • 1
    • 33751005260 scopus 로고    scopus 로고
    • Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia
    • This and the following reference demonstrate promising efficacy for pharmacological inhibition of the vasopressin V2 receptor as therapy for pathological water retention in humans
    • Schrier RW, Gross P, Gheorghiade M, et al. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 2006; 355:2099-2112. This and the following reference demonstrate promising efficacy for pharmacological inhibition of the vasopressin V2 receptor as therapy for pathological water retention in humans.
    • (2006) N Engl J Med , vol.355 , pp. 2099-2112
    • Schrier, R.W.1    Gross, P.2    Gheorghiade, M.3
  • 2
    • 33847293959 scopus 로고    scopus 로고
    • Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with Satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist
    • This and the preceding reference demonstrate promising efficacy for pharmacological inhibition of the vasopressin V2 receptor as therapy for pathological water retention in humans
    • Soupart A, Gross P, Legros J-J, et al. Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with Satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist. Clin J Am Soc Nephrol 2006; 1:1154-1160. This and the preceding reference demonstrate promising efficacy for pharmacological inhibition of the vasopressin V2 receptor as therapy for pathological water retention in humans.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 1154-1160
    • Soupart, A.1    Gross, P.2    Legros, J.-J.3
  • 3
    • 33645053034 scopus 로고    scopus 로고
    • Hyponatremia and arginine vasopressin dysregulation: Mechanisms, clinical consequences, and management
    • Miller M. Hyponatremia and arginine vasopressin dysregulation: mechanisms, clinical consequences, and management. J Am Geriatr Soc 2006; 54:345-353.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 345-353
    • Miller, M.1
  • 7
    • 0034659045 scopus 로고    scopus 로고
    • Hyponatremia and hypernatremia in the elderly
    • Kugler JP, Hustead T. Hyponatremia and hypernatremia in the elderly. Am Fam Physician 2000; 61:3623-3630.
    • (2000) Am Fam Physician , vol.61 , pp. 3623-3630
    • Kugler, J.P.1    Hustead, T.2
  • 8
    • 0035034634 scopus 로고    scopus 로고
    • Correction of hyponatremia
    • Gross P. Correction of hyponatremia. Semin Nephrol 2001; 21:269-272.
    • (2001) Semin Nephrol , vol.21 , pp. 269-272
    • Gross, P.1
  • 9
    • 0015621412 scopus 로고
    • Effect of posture on blood pressure in the elderly
    • Caird FI, Andrews GR, Kennedy RD. Effect of posture on blood pressure in the elderly. Br Heart J 1973; 35:527-530.
    • (1973) Br Heart J , vol.35 , pp. 527-530
    • Caird, F.I.1    Andrews, G.R.2    Kennedy, R.D.3
  • 10
    • 0029960059 scopus 로고    scopus 로고
    • Apparent idiopathic hyponatremia in an ambulatory geriatric population
    • Miller M, Hecker MS, Friedlander DA, Carter JM. Apparent idiopathic hyponatremia in an ambulatory geriatric population. J Am Geriatr Soc 1996; 44:404-408.
    • (1996) J Am Geriatr Soc , vol.44 , pp. 404-408
    • Miller, M.1    Hecker, M.S.2    Friedlander, D.A.3    Carter, J.M.4
  • 11
    • 0027463057 scopus 로고
    • Diuretic-induced severe hyponatremia: Review and analysis of 129 reported patients
    • Sonnenblick M, Friedlander Y, Rosin AJ. Diuretic-induced severe hyponatremia: review and analysis of 129 reported patients. Chest 1993; 103:601-606.
    • (1993) Chest , vol.103 , pp. 601-606
    • Sonnenblick, M.1    Friedlander, Y.2    Rosin, A.J.3
  • 12
    • 0029843155 scopus 로고    scopus 로고
    • Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: A review of spontaneous reports
    • Liu BA, Mittmann N, Knowles SR, Shear NH. Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports. CMAJ 1996; 155:519-527.
    • (1996) CMAJ , vol.155 , pp. 519-527
    • Liu, B.A.1    Mittmann, N.2    Knowles, S.R.3    Shear, N.H.4
  • 13
    • 10744232653 scopus 로고    scopus 로고
    • Paroxetine-induced hyponatremia in older adults: A 12-week prospective study
    • Fabian TJ, Amico JA, Kroboth PD, et al. Paroxetine-induced hyponatremia in older adults: a 12-week prospective study. Arch Intern Med 2004; 164:327-332.
    • (2004) Arch Intern Med , vol.164 , pp. 327-332
    • Fabian, T.J.1    Amico, J.A.2    Kroboth, P.D.3
  • 14
    • 0022637771 scopus 로고
    • Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure
    • Lee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation 1986; 73:257-267.
    • (1986) Circulation , vol.73 , pp. 257-267
    • Lee, W.H.1    Packer, M.2
  • 15
    • 0033658150 scopus 로고    scopus 로고
    • Clinical relevance of hyponatraemia for the hospital outcome of cirrhotic patients
    • Borroni G,Maggi A, Sangiovanni A, et al. Clinical relevance of hyponatraemia for the hospital outcome of cirrhotic patients. Dig Liver Dis 2000; 32:605-610.
    • (2000) Dig Liver Dis , vol.32 , pp. 605-610
    • Borroni, G.1    Maggi, A.2    Sangiovanni, A.3
  • 16
    • 0022964788 scopus 로고
    • The prognosis of hyponatremia at hospital admission
    • Tierney WM, Martin DK, Greenlee MC, et al. The prognosis of hyponatremia at hospital admission. J Gen Intern Med 1986; 1:380-385.
    • (1986) J Gen Intern Med , vol.1 , pp. 380-385
    • Tierney, W.M.1    Martin, D.K.2    Greenlee, M.C.3
  • 17
    • 4143148607 scopus 로고    scopus 로고
    • Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction
    • Goldberg A, Hammerman H, Petcherski S, et al. Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction. Am J Med 2004; 117:242-248.
    • (2004) Am J Med , vol.117 , pp. 242-248
    • Goldberg, A.1    Hammerman, H.2    Petcherski, S.3
  • 18
    • 0023623546 scopus 로고
    • Severe symptomatic hyponatremia: Treatment and outcome: a study of 64 cases
    • Sterns RH. Severe symptomatic hyponatremia: treatment and outcome: a study of 64 cases. Ann Intern Med 1987; 107:656-664.
    • (1987) Ann Intern Med , vol.107 , pp. 656-664
    • Sterns, R.H.1
  • 19
    • 30944460468 scopus 로고    scopus 로고
    • Renneboog B, Musch W, Vandemergel X, et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006; 119:71.e1-8. An interesting documentation of the reversible neurological sequelae accompanying even mild water retention in human subjects.
    • Renneboog B, Musch W, Vandemergel X, et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006; 119:71.e1-8. An interesting documentation of the reversible neurological sequelae accompanying even mild water retention in human subjects.
  • 20
    • 0032452214 scopus 로고    scopus 로고
    • Osmoregulation of vasopressin neurons: A synergy of intrinsic and synaptic processes
    • Bourque CW. Osmoregulation of vasopressin neurons: a synergy of intrinsic and synaptic processes. Prog Brain Res 1998; 119:59-76.
    • (1998) Prog Brain Res , vol.119 , pp. 59-76
    • Bourque, C.W.1
  • 21
    • 0022347577 scopus 로고
    • Rescue of the Drosophila phototransduction mutation trp by germline transformation
    • Montell C, Jones K, Hafen E, Rubin G. Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science 1985; 230:1040-1043.
    • (1985) Science , vol.230 , pp. 1040-1043
    • Montell, C.1    Jones, K.2    Hafen, E.3    Rubin, G.4
  • 22
    • 0024642547 scopus 로고
    • Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction
    • Montell C, Rubin GM. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 1989; 2:1313-1323.
    • (1989) Neuron , vol.2 , pp. 1313-1323
    • Montell, C.1    Rubin, G.M.2
  • 23
    • 0017335111 scopus 로고
    • Drosophila mutant with a transducer defect
    • Minke B. Drosophila mutant with a transducer defect. Biophys Struct Mech 1977; 3:59-64.
    • (1977) Biophys Struct Mech , vol.3 , pp. 59-64
    • Minke, B.1
  • 24
    • 33846807748 scopus 로고    scopus 로고
    • Transient receptor potential cation channels in disease
    • A noteworthy and comprehensive review from a leading group in the field
    • Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007; 87:165-217. A noteworthy and comprehensive review from a leading group in the field.
    • (2007) Physiol Rev , vol.87 , pp. 165-217
    • Nilius, B.1    Owsianik, G.2    Voets, T.3    Peters, J.A.4
  • 26
    • 22844436647 scopus 로고    scopus 로고
    • TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    • Reiser J, Polu KR, Moller CC, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005; 37:739-744.
    • (2005) Nat Genet , vol.37 , pp. 739-744
    • Reiser, J.1    Polu, K.R.2    Moller, C.C.3
  • 27
    • 20844461826 scopus 로고    scopus 로고
    • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
    • Winn MP, Conlon PJ, Lynn KL, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005;308:1801-1804.
    • (2005) Science , vol.308 , pp. 1801-1804
    • Winn, M.P.1    Conlon, P.J.2    Lynn, K.L.3
  • 28
    • 18544369466 scopus 로고    scopus 로고
    • Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    • Schlingmann KP, Weber S, Peters M, et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 2002; 31:166-170.
    • (2002) Nat Genet , vol.31 , pp. 166-170
    • Schlingmann, K.P.1    Weber, S.2    Peters, M.3
  • 29
    • 33847137308 scopus 로고    scopus 로고
    • Starch fossils and the domestication and dispersal of chili peppers (Capsicum spp. L. ) in the Americas
    • Perry L, Dickau R, Zarrillo S, et al. Starch fossils and the domestication and dispersal of chili peppers (Capsicum spp. L. ) in the Americas. Science 2007; 315:986-988.
    • (2007) Science , vol.315 , pp. 986-988
    • Perry, L.1    Dickau, R.2    Zarrillo, S.3
  • 30
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389:816-824.
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3
  • 31
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000; 288:306-313.
    • (2000) Science , vol.288 , pp. 306-313
    • Caterina, M.J.1    Leffler, A.2    Malmberg, A.B.3
  • 32
    • 0036183319 scopus 로고    scopus 로고
    • Molecular basis for species-specific sensitivity to 'hot' chili peppers
    • Jordt SE, Julius D. Molecular basis for species-specific sensitivity to 'hot' chili peppers. Cell 2002; 108:421-430.
    • (2002) Cell , vol.108 , pp. 421-430
    • Jordt, S.E.1    Julius, D.2
  • 33
    • 0028931470 scopus 로고
    • Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans
    • Colbert HA, Bargmann CI. Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 1995; 14:803-812.
    • (1995) Neuron , vol.14 , pp. 803-812
    • Colbert, H.A.1    Bargmann, C.I.2
  • 34
    • 0030776196 scopus 로고    scopus 로고
    • OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans
    • Colbert HA, Smith TL, Bargmann CI. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 1997; 17:8259-8269.
    • (1997) J Neurosci , vol.17 , pp. 8259-8269
    • Colbert, H.A.1    Smith, T.L.2    Bargmann, C.I.3
  • 35
    • 0034721648 scopus 로고    scopus 로고
    • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    • Liedtke W, Choe Y, Marti-Renom MA, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 2000; 103:525-535.
    • (2000) Cell , vol.103 , pp. 525-535
    • Liedtke, W.1    Choe, Y.2    Marti-Renom, M.A.3
  • 36
    • 0034306198 scopus 로고    scopus 로고
    • OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
    • Strotmann R, Harteneck C, Nunnenmacher K, et al. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2000; 2:695-702.
    • (2000) Nat Cell Biol , vol.2 , pp. 695-702
    • Strotmann, R.1    Harteneck, C.2    Nunnenmacher, K.3
  • 38
    • 0348142491 scopus 로고    scopus 로고
    • Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
    • Delany NS, Hurle M, Facer P, et al. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics 2001; 4:165-174.
    • (2001) Physiol Genomics , vol.4 , pp. 165-174
    • Delany, N.S.1    Hurle, M.2    Facer, P.3
  • 39
    • 0036703646 scopus 로고    scopus 로고
    • Caterina M: Heat-evoked activation of the ion channel, TRPV4
    • Guler AD, Lee H, Iida T, et al. Caterina M: Heat-evoked activation of the ion channel, TRPV4. J Neurosci 2002; 22:6408-6414.
    • (2002) J Neurosci , vol.22 , pp. 6408-6414
    • Guler, A.D.1    Lee, H.2    Iida, T.3
  • 40
    • 2942677310 scopus 로고    scopus 로고
    • Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments
    • Tian W, Salanova M, Xu H, et al. Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol 2004; 287:F17-F24.
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Tian, W.1    Salanova, M.2    Xu, H.3
  • 42
    • 0345659198 scopus 로고    scopus 로고
    • Abnormal osmotic regulation in trpv4-/- mice
    • Liedtke W, Friedman JM. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A 2003; 100:13698-13703.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13698-13703
    • Liedtke, W.1    Friedman, J.M.2
  • 43
    • 0038175469 scopus 로고    scopus 로고
    • Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress
    • Xu H, Zhao H, Tian W, et al. Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 2003; 278:11520-11527.
    • (2003) J Biol Chem , vol.278 , pp. 11520-11527
    • Xu, H.1    Zhao, H.2    Tian, W.3
  • 44
    • 0347719316 scopus 로고    scopus 로고
    • Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
    • Vriens J, Watanabe H, Janssens A, et al. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A 2004; 101:396-401.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 396-401
    • Vriens, J.1    Watanabe, H.2    Janssens, A.3
  • 45
    • 0041695412 scopus 로고    scopus 로고
    • Hypotonicity induces TRPV4-mediated nociception in rat
    • Alessandri-Haber N, Yeh JJ, Boyd AE, et al. Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 2003; 39:497-511.
    • (2003) Neuron , vol.39 , pp. 497-511
    • Alessandri-Haber, N.1    Yeh, J.J.2    Boyd, A.E.3
  • 46
    • 13644252212 scopus 로고    scopus 로고
    • SRC family kinases in cell volume regulation
    • Cohen D. SRC family kinases in cell volume regulation. Am J Physiol Cell Physiol 2005; 288:C483-C493.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Cohen, D.1
  • 47
    • 2442542398 scopus 로고    scopus 로고
    • Regulation of TRPC6 channel activity by tyrosine phosphorylation
    • Hisatsune C, Kuroda Y, Nakamura K, et al. Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 2004; 279:18887-18894.
    • (2004) J Biol Chem , vol.279 , pp. 18887-18894
    • Hisatsune, C.1    Kuroda, Y.2    Nakamura, K.3
  • 48
    • 0242322027 scopus 로고    scopus 로고
    • Regulation of a TRPM7-like current in rat brain microglia
    • Jiang X, Newell EW, Schlichter LC. Regulation of a TRPM7-like current in rat brain microglia. J Biol Chem 2003; 278:42867-42876.
    • (2003) J Biol Chem , vol.278 , pp. 42867-42876
    • Jiang, X.1    Newell, E.W.2    Schlichter, L.C.3
  • 49
    • 3242659099 scopus 로고    scopus 로고
    • Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase
    • Jin X, Morsy N, Winston J, et al. Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. Am J Physiol Cell Physiol 2004; 287:C558-C563.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Jin, X.1    Morsy, N.2    Winston, J.3
  • 50
    • 4644314868 scopus 로고    scopus 로고
    • Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels
    • Vazquez G, Wedel BJ, Kawasaki BT, et al. Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels. J Biol Chem 2004; 279:40521-40528.
    • (2004) J Biol Chem , vol.279 , pp. 40521-40528
    • Vazquez, G.1    Wedel, B.J.2    Kawasaki, B.T.3
  • 51
    • 0043267987 scopus 로고    scopus 로고
    • Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    • Watanabe H, Vriens J, Prenen J, et al. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 2003; 424:434-438.
    • (2003) Nature , vol.424 , pp. 434-438
    • Watanabe, H.1    Vriens, J.2    Prenen, J.3
  • 52
    • 27644497526 scopus 로고    scopus 로고
    • Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium
    • Vriens J, Owsianik G, Fisslthaler B, et al. Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 2005; 97:908-915.
    • (2005) Circ Res , vol.97 , pp. 908-915
    • Vriens, J.1    Owsianik, G.2    Fisslthaler, B.3
  • 53
    • 0030779803 scopus 로고    scopus 로고
    • Cell swelling activates phospholipase A2 in Ehrlich ascites tumor cells
    • Thoroed SM, Lauritzen L, Lambert IH, et al. Cell swelling activates phospholipase A2 in Ehrlich ascites tumor cells. J Membr Biol 1997; 160:47-58.
    • (1997) J Membr Biol , vol.160 , pp. 47-58
    • Thoroed, S.M.1    Lauritzen, L.2    Lambert, I.H.3
  • 54
    • 0031953207 scopus 로고    scopus 로고
    • Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells
    • Basavappa S, Pedersen SF, Jorgensen NK, et al. Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. J Neurophysiol 1998; 79:1441-1449.
    • (1998) J Neurophysiol , vol.79 , pp. 1441-1449
    • Basavappa, S.1    Pedersen, S.F.2    Jorgensen, N.K.3
  • 55
    • 0033850814 scopus 로고    scopus 로고
    • Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells
    • Pedersen S, Lambert IH, Thoroed SM, Hoffmann EK. Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells. Eur J Biochem 2000; 267:5531-5539.
    • (2000) Eur J Biochem , vol.267 , pp. 5531-5539
    • Pedersen, S.1    Lambert, I.H.2    Thoroed, S.M.3    Hoffmann, E.K.4
  • 56
    • 11144231273 scopus 로고    scopus 로고
    • Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia
    • Arniges M, Vazquez E, Fernandez-Fernandez JM, Valverde MA. Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 2004; 279:54062-54068.
    • (2004) J Biol Chem , vol.279 , pp. 54062-54068
    • Arniges, M.1    Vazquez, E.2    Fernandez-Fernandez, J.M.3    Valverde, M.A.4
  • 57
    • 21044435352 scopus 로고    scopus 로고
    • TRPV4 exhibits a functional role in cell-volume regulation
    • Becker D, Blase C, Bereiter-Hahn J, Jendrach M. TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 2005; 118:2435-2440.
    • (2005) J Cell Sci , vol.118 , pp. 2435-2440
    • Becker, D.1    Blase, C.2    Bereiter-Hahn, J.3    Jendrach, M.4
  • 58
    • 33744948236 scopus 로고    scopus 로고
    • Liu X, Bandyopadhyay B, Nakamoto T, et al. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell recovery. J Biol Chem 2006; 281:15485-15495. This and the following study reflect an emerging appreciation of the functional interaction between TRPV4 and the apically expressed pulmonary alveolar epithelial water channel, aquaporin-5.
    • Liu X, Bandyopadhyay B, Nakamoto T, et al. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 2006; 281:15485-15495. This and the following study reflect an emerging appreciation of the functional interaction between TRPV4 and the apically expressed pulmonary alveolar epithelial water channel, aquaporin-5.
  • 60
    • 0037697228 scopus 로고    scopus 로고
    • Temperature-modulated diversity of TRPV4 channel gating: Activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways
    • Gao X, Wu L, O'Neil RG. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem 2003; 278:27129-27137.
    • (2003) J Biol Chem , vol.278 , pp. 27129-27137
    • Gao, X.1    Wu, L.2    O'Neil, R.G.3
  • 61
    • 0038604287 scopus 로고    scopus 로고
    • Impaired pressure sensation in mice lacking TRPV4
    • Suzuki M, Mizuno A, Kodaira K, Imai M. Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 2003; 278:22664-22668.
    • (2003) J Biol Chem , vol.278 , pp. 22664-22668
    • Suzuki, M.1    Mizuno, A.2    Kodaira, K.3    Imai, M.4
  • 62
    • 15544377977 scopus 로고    scopus 로고
    • TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity
    • Andrade YN, Fernandes J, Vazquez E, et al. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 2005; 168:869-874.
    • (2005) J Cell Biol , vol.168 , pp. 869-874
    • Andrade, Y.N.1    Fernandes, J.2    Vazquez, E.3
  • 63
    • 0242266967 scopus 로고    scopus 로고
    • TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes
    • Muraki K, Iwata Y, Katanosaka Y, et al. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 2003; 93:829-838.
    • (2003) Circ Res , vol.93 , pp. 829-838
    • Muraki, K.1    Iwata, Y.2    Katanosaka, Y.3
  • 64
    • 0036728668 scopus 로고    scopus 로고
    • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
    • Birder LA, Nakamura Y, Kiss S, et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 2002; 5:856-860.
    • (2002) Nat Neurosci , vol.5 , pp. 856-860
    • Birder, L.A.1    Nakamura, Y.2    Kiss, S.3
  • 65
    • 0035818575 scopus 로고    scopus 로고
    • Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells
    • Birder LA, Kanai AJ, de Groat WC, et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A 2001; 98:13396-13401.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 13396-13401
    • Birder, L.A.1    Kanai, A.J.2    de Groat, W.C.3
  • 66
    • 8844269437 scopus 로고    scopus 로고
    • Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice
    • Rong W, Hillsley K, Davis JB, et al. Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol 2004; 560:867-881.
    • (2004) J Physiol , vol.560 , pp. 867-881
    • Rong, W.1    Hillsley, K.2    Davis, J.B.3
  • 67
    • 8844262481 scopus 로고    scopus 로고
    • Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: A novel mechanism involved in myogenic constriction
    • Scotland RS, Chauhan S, Davis C, et al. Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res 2004; 95:1027-1034.
    • (2004) Circ Res , vol.95 , pp. 1027-1034
    • Scotland, R.S.1    Chauhan, S.2    Davis, C.3
  • 68
    • 29444456617 scopus 로고    scopus 로고
    • Sharif Naeini R, Witty MF, Seguela P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 2006; 9:93-98. An extraordinary report strongly suggesting that a splice variant of TRPV1 is instrumental in the central response to systemic hypertonicity. Although the authors were able to PCR-amplify a portion of the TRPV1 cDNA from magnocellular (vasopressin-producing) neurons, they were unable to amplify a full-length clone. This led them to speculate that a potentially novel splice variant of TRPV1 was required.
    • Sharif Naeini R, Witty MF, Seguela P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 2006; 9:93-98. An extraordinary report strongly suggesting that a splice variant of TRPV1 is instrumental in the central response to systemic hypertonicity. Although the authors were able to PCR-amplify a portion of the TRPV1 cDNA from magnocellular (vasopressin-producing) neurons, they were unable to amplify a full-length clone. This led them to speculate that a potentially novel splice variant of TRPV1 was required.
  • 69
    • 0141430976 scopus 로고    scopus 로고
    • Zhang Z, Bourque CW. Osmometry in osmosensory neurons. Nat Neurosci 2003; 6:1021-1022.
    • Zhang Z, Bourque CW. Osmometry in osmosensory neurons. Nat Neurosci 2003; 6:1021-1022.
  • 70
    • 0001762186 scopus 로고    scopus 로고
    • The lamina terminalis and its role in fluid and electrolyte homeostasis
    • McKinley MJ, Gerstberger R, Mathai ML, et al. The lamina terminalis and its role in fluid and electrolyte homeostasis. J Clin Neurosci 1999; 6:289-301.
    • (1999) J Clin Neurosci , vol.6 , pp. 289-301
    • McKinley, M.J.1    Gerstberger, R.2    Mathai, M.L.3
  • 71
    • 33748255730 scopus 로고    scopus 로고
    • Ciura S, Bourque CW. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 2006; 26:9069-9075. A follow-up observation to reference 68, wherein hypertonicity responsiveness was demonstrated in the 'upstream' neurons of the lamina terminalis, in contrast to the 'downstream' magnocellular (vasopressin- producing) neurons investigated in the earlier report.
    • Ciura S, Bourque CW. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 2006; 26:9069-9075. A follow-up observation to reference 68, wherein hypertonicity responsiveness was demonstrated in the 'upstream' neurons of the lamina terminalis, in contrast to the 'downstream' magnocellular (vasopressin- producing) neurons investigated in the earlier report.
  • 72
    • 0034724402 scopus 로고    scopus 로고
    • Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
    • Mezey E, Toth ZE, Cortright DN, et al. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A 2000; 97:3655-3660.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3655-3660
    • Mezey, E.1    Toth, Z.E.2    Cortright, D.N.3
  • 74
    • 33747860824 scopus 로고    scopus 로고
    • The cells and logic for mammalian sour taste detection
    • Huang AL, Chen X, Hoon MA, et al. The cells and logic for mammalian sour taste detection. Nature 2006; 442:934-938.
    • (2006) Nature , vol.442 , pp. 934-938
    • Huang, A.L.1    Chen, X.2    Hoon, M.A.3
  • 75
    • 4043162667 scopus 로고    scopus 로고
    • The mammalian amiloride-insensitive nonspecific salt taste receptor is a vanilloid receptor-1 variant
    • Lyall V, Heck GL, Vinnikova AK, et al. The mammalian amiloride-insensitive nonspecific salt taste receptor is a vanilloid receptor-1 variant. J Physiol 2004; 558:147-159.
    • (2004) J Physiol , vol.558 , pp. 147-159
    • Lyall, V.1    Heck, G.L.2    Vinnikova, A.K.3
  • 76
    • 0034723256 scopus 로고    scopus 로고
    • Molecular cloning of an N-terminal splice variant of the capsaicin receptor: Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes
    • Schumacher MA, Moff I, Sudanagunta SP, Levine JD. Molecular cloning of an N-terminal splice variant of the capsaicin receptor: loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. J Biol Chem 2000; 275:2756-2762.
    • (2000) J Biol Chem , vol.275 , pp. 2756-2762
    • Schumacher, M.A.1    Moff, I.2    Sudanagunta, S.P.3    Levine, J.D.4
  • 77
    • 0033525705 scopus 로고    scopus 로고
    • Cloning of a stretch-inhibitable nonselective cation channel
    • Suzuki M, Sato J, Kutsuwada K, et al. Cloning of a stretch-inhibitable nonselective cation channel. J Biol Chem 1999; 274:6330-6335.
    • (1999) J Biol Chem , vol.274 , pp. 6330-6335
    • Suzuki, M.1    Sato, J.2    Kutsuwada, K.3
  • 78
    • 4444258203 scopus 로고    scopus 로고
    • An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels
    • Wang C, Hu HZ, Colton CK, et al. An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels. J Biol Chem 2004; 279:37423-37430.
    • (2004) J Biol Chem , vol.279 , pp. 37423-37430
    • Wang, C.1    Hu, H.Z.2    Colton, C.K.3
  • 79
    • 15744394354 scopus 로고    scopus 로고
    • TRPV1b: A functional human vanilloid receptor splice variant
    • Lu G, Henderson D, Liu L, et al. TRPV1b: a functional human vanilloid receptor splice variant. Mol Pharmacol 2005; 67:1119-1127.
    • (2005) Mol Pharmacol , vol.67 , pp. 1119-1127
    • Lu, G.1    Henderson, D.2    Liu, L.3
  • 80
    • 33644796336 scopus 로고    scopus 로고
    • Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant
    • Tian W, Fu Y, Wang DH, Cohen DM. Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant. Am J Physiol Renal Physiol 2006; 290:F117-F126.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Tian, W.1    Fu, Y.2    Wang, D.H.3    Cohen, D.M.4
  • 81
    • 26444509763 scopus 로고    scopus 로고
    • TRPV4 and the mammalian kidney
    • Cohen D. TRPV4 and the mammalian kidney. Pflugers Arch 2005; 451:168-175.
    • (2005) Pflugers Arch , vol.451 , pp. 168-175
    • Cohen, D.1
  • 82
    • 21544480555 scopus 로고    scopus 로고
    • Teilmann SC, Byskov AG, Pedersen PA, et al. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 2005; 71:444-452. An abstract localizing TRPV4 expression to the mechanosensory apical cilium of renal epithelial cells in culture, and suggesting a functional interaction with polycystin-2.
    • Teilmann SC, Byskov AG, Pedersen PA, et al. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 2005; 71:444-452. An abstract localizing TRPV4 expression to the mechanosensory apical cilium of renal epithelial cells in culture, and suggesting a functional interaction with polycystin-2.
  • 83
    • 34547899397 scopus 로고    scopus 로고
    • Koettgen M, Bucholz B, Steffl D, et al. Polycystin-2 and TRPV4 form a functional heteromultimeric complex that might act as a cilial mechanosensor [abstract]. J Am Soc Nephrol 2005; 16:25A. An abstract localizing TRPV4 expression to the mechanosensory apical cilium of renal epithelial cells in culture, and suggesting a functional interaction with polycystin-2.
    • Koettgen M, Bucholz B, Steffl D, et al. Polycystin-2 and TRPV4 form a functional heteromultimeric complex that might act as a cilial mechanosensor [abstract]. J Am Soc Nephrol 2005; 16:25A. An abstract localizing TRPV4 expression to the mechanosensory apical cilium of renal epithelial cells in culture, and suggesting a functional interaction with polycystin-2.
  • 84
    • 85133395795 scopus 로고    scopus 로고
    • -/- mice.
    • -/- mice.
  • 85
    • 33748648566 scopus 로고    scopus 로고
    • Reiter B, Kraft R, Gunzel D, et al. TRPV4-mediated regulation of epithelial permeability. Faseb J 2006; 20:1802-1812. An analysis of effector pathways following TRPV4 activation that may be involved in mediating transcellular ion flux.
    • Reiter B, Kraft R, Gunzel D, et al. TRPV4-mediated regulation of epithelial permeability. Faseb J 2006; 20:1802-1812. An analysis of effector pathways following TRPV4 activation that may be involved in mediating transcellular ion flux.
  • 86
    • 0034816158 scopus 로고    scopus 로고
    • The tissue distribution and functional characterization of human VR1
    • Cortright DN, Crandall M, Sanchez JF, et al. The tissue distribution and functional characterization of human VR1. Biochem Biophys Res Commun 2001; 281:1183-1189.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 1183-1189
    • Cortright, D.N.1    Crandall, M.2    Sanchez, J.F.3
  • 87
    • 0035940785 scopus 로고    scopus 로고
    • The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat
    • Sanchez JF, Krause JE, Cortright DN. The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat. Neuroscience 2001; 107:373-381.
    • (2001) Neuroscience , vol.107 , pp. 373-381
    • Sanchez, J.F.1    Krause, J.E.2    Cortright, D.N.3
  • 88
    • 0025970984 scopus 로고
    • Inhibitory renorenal reflexes: A role for substance P or other capsaicin-sensitive neurons
    • Kopp UC, Smith LA. Inhibitory renorenal reflexes: a role for substance P or other capsaicin-sensitive neurons. Am J Physiol 1991; 260:R232-R239.
    • (1991) Am J Physiol , vol.260
    • Kopp, U.C.1    Smith, L.A.2
  • 89
    • 33644660267 scopus 로고    scopus 로고
    • Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats
    • Zhu Y, Wang Y, Wang DH. Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats. Hypertension 2005; 46:992-997.
    • (2005) Hypertension , vol.46 , pp. 992-997
    • Zhu, Y.1    Wang, Y.2    Wang, D.H.3
  • 90
    • 0031015981 scopus 로고    scopus 로고
    • Neural control of renal function
    • DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 1997; 77:75-197.
    • (1997) Physiol Rev , vol.77 , pp. 75-197
    • DiBona, G.F.1    Kopp, U.C.2
  • 91
    • 33947188494 scopus 로고    scopus 로고
    • Neural control of blood pressure: Focusing on capsaicin-sensitive sensory nerves
    • Wang Y, Wang DH. Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. Cardiovasc Hematol Disord Drug Targets 2007; 7:37-46.
    • (2007) Cardiovasc Hematol Disord Drug Targets , vol.7 , pp. 37-46
    • Wang, Y.1    Wang, D.H.2


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