Association evidence of schizophrenia with distal genomic region of NOTCH4 in Taiwanese families

Genes, Brain and Behavior

Volumn 6, Issue 6, 2007, Pages 497-502

  Liu, C M ^a,b   Liu, Y L ^a   Fann, C S J ^c   Chen, W J ^d   Yang, W C ^c   Ouyang, W C ^e   Chen, C Y ^f   Jou, Y S ^c   Hsieh, M H ^a   Liu, S K ^a   Hwang, T J ^a   Faraone, S V ^g   Tsuang, M T ^h,i   Hwu, H G ^a,d  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e Chia Nan Psychiatric Center   (Taiwan)

^f Tsaotun Psychiatric Center   (Taiwan)

^g SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ HARVARD UNIVERSITY   (United States)

Author keywords

Chromosome 6p; Family based association study; NOTCH4; Schizophrenia

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR;

ADULT; ALLELE; ARTICLE; B CELL LEUKEMIA; COMPUTER PROGRAM; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE REPLICATION; GENOMICS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

GENE FREQUENCY; HUMANS; LINKAGE DISEQUILIBRIUM; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, NOTCH2; SCHIZOPHRENIA; TAIWAN;

EID: 34547844133     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2006.00276.x     Document Type: Article

References (46)

1. Abecasis, G.R. Cookson, W.O 2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics 16, 182 183.
2. Abecasis, G.R., Cardon, L.R. Cookson, W.O 2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66, 279 292.
3. Antonarakis, S.E., Blouin, J.L., Pulver, A.E., Wolyniec, P., Lasseter, V.K., Nestadt, G., Kasch, L., Babb, R., Kazazian, H.H., Dombroski, B., Kimberland, M., Ott, J., Housman, D., Karayiorgou, M. MacLean, C.J 1995) Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 11, 235 236.
4. Anttila, S., Kampman, O., Illi, A., Roivas, M., Mattila, K.M., Lassila, V., Lehtimaki, T. Leinonen, E 2003) NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia. Psychiatr Genet 13, 61 64.
5. APA (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th Edn. American Psychiatric Association, Washington, DC.
6. Carmine, A., Chheda, M.G., Jonsson, E.G., Sedvall, G.C., Farde, L., Gustavsson, J.P., Bergman, H., Anvret, M., Buervenich, S. Olson, L 2003) Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits. Psychiatr Genet 13, 23 28.
7. Chen, W.J., Liu, S.K., Chang, C.J., Lien, Y.J., Chang, Y.H. Hwu, H.G 1998) Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry 155, 1214 1220.
8. Clayton, D 1999) A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65, 1170 1177.
9. Fan, J.B., Tang, J.X., Gu, N.F., Feng, G.Y., Zou, F.G., Xing, Y.L., Shi, J.G., Zhao, S.M., Zhu, S.M., Ji, L.P., Sun, W.W., Zheng, Y.L., Liu, W.Q., Breen, G., St Clair, D. He, L 2002) A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Mol Psychiatry 7, 100 103.
10. Glatt, S.J., Wang, R.S., Yeh, Y.C., Tsuang, M.T. Faraone, S.V 2005) Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses. Schizophr Res 73, 281 290.
11. Hedrick, P.W 1987) Gametic disequilibrium measures: proceed with caution. Genetics 117, 331 341.
12. Hwu, H.G 1999) Psychiatric diagnostic assessment, 2nd Edn. Publication Committee, College of Medicine, National Taiwan University, Taipei.
13. Hwu, H.G., Yeh, E.K. Chang, L.Y 1989) Prevalence of psychiatric disorders in Taiwan defined by the Chinese Diagnostic Interview Schedule. Acta Psychiatr Scand 79, 136 147.
14. Hwu, H.G., Lin, M.W., Lee, P.C., Lee, S.F., Ou-Yang, W.C. Liu, C.M 2000) Evaluation of linkage of markers on chromosome 6p with schizophrenia in Taiwanese families. Am J Med Genet 96, 74 78.
15. Hwu, H.G., Chen, C.H., Hwang, T.J., Liu, C.M., Cheng, J.J., Lin, S.K., Liu, S.K., Chen, C.H., Chi, Y.Y., Ou-Young, C.W., Lin, H.N. Chen, W.J 2002) Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admission. Schizophr Res 56, 105 119.
16. Hwu, H.G., Faraone, S.V., Liu, C.M., Chen, W.J., Liu, S.K., Shieh, M.H., Hwang, T.J., Tsuang, M.M., OuYang, W.C., Chen, C.Y., Chen, C.C., Lin, J.J., Chou, F.H., Chueh, C.M., Liu, W.M., Hall, M.H. Tsuang, M.T 2005) Taiwan schizophrenia linkage study: the field study. Am J Med Genet B Neuropsychiatr Genet 134, 30 36.
17. Imai, K., Harada, S., Kawanishi, Y., Tachikawa, H., Okubo, T. Suzuki, T 2001) The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals. BMC Psychiatry 1, 1.
18. Institute, S 2002) SAS/Genetics User's Guide. SAS Institute Inc., Cary.
19. Kaneko, N., Muratake, T., Amagane, H., Sakurai, M., Tanaka, T., Tsuji, S. Someya, T 2004) Transmission disequilibrium test and haplotype analysis of the NOTCH4 gene in Japanese patients with schizophrenia. Psychiatry Clin Neurosci 58, 199 205.
20. Lange, C., DeMeo, D., Silverman, E.K., Weiss, S.T. Laird, N.M 2004) PBAT: tools for family-based association studies. Am J Hum Genet 74, 367 369.
21. Lewis, D.A. Levitt, P 2002) Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25, 409 432.
22. Liang, K.Y., Chiu, Y.F. Beaty, T.H 2001) A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases. Hum Hered 51, 64 78.
23. Luo, X., Klempan, T.A., Lappalainen, J., Rosenheck, R.A., Charney, D.S., Erdos, J., van Kammen, D.P., Kranzler, H.R., Kennedy, J.L. Gelernter, J 2004) NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biol Psychiatry 55, 112 117.
24. McGinnis, R.E., Fox, H., Yates, P., Cameron, L.A., Barnes, M.R., Gray, I.C., Spurr, N.K., Hurko, O. St Clair, D 2001) Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nat Genet 28, 128 129.
25. McGuffin, P., Tandon, K. Corsico, A 2003) Linkage and association studies of schizophrenia. Curr Psychiatry Rep 5, 121 127.
26. Moises, H.W., Yang, L., Kristbjarnarson, H. Wiese, C., Byerley, W., Macciardi, F., Arolt, V., Blackwood, D., Liu, X., Sjogren, B. et al 1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 11, 321 324.
27. O'Connell, J.R. Weeks, D.E 1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63, 259 266.
28. Prasad, S., Chowdari, K.V., Wood, J., Bhatia, T., Deshpande, S.N., Nimgaonkar, V.L. Thelma, B.K 2004) Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples. Am J Med Genet B Neuropsychiatr Genet 131, 6 9.
29. Risch, N 1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46, 222 228.
30. Sestan, N., Artavanis-Tsakonas, S. Rakic, P 1999) Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286, 741 746.
31. Sklar, P., Schwab, S.G., Williams, N.M. et al 2001) Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 28, 126 128.
32. Skol, A.D., Young, K.A., Tsuang, D.W. et al 2003) Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet B Neuropsychiatr Genet 118, 8 15.
33. Spielman, R.S. Ewens, W.J 1998) A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 62, 450 458.
34. Spielman, R.S., McGinnis, R.E. Ewens, W.J 1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52, 506 516.
35. Straub, R.E., MacLean, C.J., O'Neill, F.A., Burke, J., Murphy, B., Duke, F., Shinkwin, R., Webb, B.T., Zhang, J., Walsh, D. Kendler, K.S 1995) A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 11, 287 293.
36. Sugaya, K., Sasanuma, S., Nohata, J., Kimura, T., Fukagawa, T., Nakamura, Y., Ando, A., Inoko, H., Ikemura, T. Mita, K 1997) Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3. Gene 189, 235 244.
37. Takahashi, S., Cui, Y.H., Kojima, T., Han, Y.H., Yu, S.Y., Tanabe, E., Yara, K., Matsuura, M., Matsushima, E., Nakayama, J., Arinami, T., Shen, Y.C., Faraone, S.V. Tsuang, M.T 2003) Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples. Biol Psychiatry 54, 129 135.
38. Terwilliger, J. Ott, J 1994) Handbook for Human Genetic Linkage. Johns Hopkins University Press, Baltimore.
39. Tochigi, M., Zhang, X., Umekage, T., Ohashi, J., Kato, C., Marui, T., Otowa, T., Hibino, H., Otani, T., Kohda, K., Liu, S., Kato, N., Tokunaga, K. Sasaki, T 2004) Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet B 128, 37 40.
40. Ujike, H., Takehisa, Y., Takaki, M., Tanaka, Y., Nakata, K., Takeda, T., Kodama, M., Fujiwara, Y., Yamamoto, A. Kuroda, S 2001) NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neurosci Lett 301, 41 44.
41. Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D. Kitajewski, J 1996) Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122, 2251 2259.
42. Walker, L., Carlson, A., Tan-Pertel, H.T., Weinmaster, G. Gasson, J 2001) The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse. Stem Cells 19, 543 552.
43. Wang, S., Sun, C.E., Walczak, C.A., Ziegle, J.S., Kipps, B.R., Goldin, L.R. Diehl, S.R 1995) Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10, 41 46.
44. Wassink, T.H., Nopoulos, P., Pietila, J., Crowe, R.R. Andreasen, N.C 2003) NOTCH4 and the frontal lobe in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 118, 1 7.
45. Wei, J. Hemmings, G.P 2000) The NOTCH4 locus is associated with susceptibility to schizophrenia. Nat Genet 25, 376 377.
46. Zhang, X., Wei, J., Yu, Y.Q., Liu, S.Z., Shi, J.P., Liu, L.L., Ju, G.Z., Yang, J.Z., Zhang, D., Xu, Q., Shen, Y. Hemmings, G.P 2004) Is NOTCH4 associated with schizophrenia? Psychiatr Genet 14, 43 46.