Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 128 B, Issue 1, 2004, Pages 37-40

  Tochigi, Mamoru ^a   Zhang, Xuan ^a,b   Umekage, Tadashi ^a,c   Ohashi, Jun ^a   Kato, Chieko ^a   Marui, Tetsuya ^a   Otowa, Takeshi ^a   Hibino, Hiroyuki ^a   Otani, Toshiyuki ^a   Kohda, Kazuhisa ^a   Liu, Shuzheng ^b   Kato, Nobumasa ^a   Tokunaga, Katsushi ^a   Sasaki, Tsukasa ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chromosome 6; Genetics; Haplotype; Microsatellite; SNP

Indexed keywords

NOTCH RECEPTOR;

ADULT; ARTICLE; CHINESE; CHROMOSOME 6P; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENE LOCATION; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; NOTCH4 GENE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 6; EPIDEMIOLOGY, MOLECULAR; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SCHIZOPHRENIA; TRINUCLEOTIDE REPEATS;

EID: 3042842672     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Anttila S, Kampman O, Illi A, Roivas M, Mattila KM, Lassila V, Lehtimaki T, Leinonen E. 2003. NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia. Psychiatr Genet 13:61-64.
2. Carmine A, Chheda MG, Jonsson EG, Sedvall GC, Farde L, Gustavsson JP, Bergman H, Anvret M, Buervenich S, Olson L. 2003. Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits. Psychiatr Genet 13:23-28.
3. Fan JB, Tang JX, Gu NF, Feng GY, Zou FG, Xing YL, Shi JG, Zhao SM, Zhu SM, Ji LP, Sun WW, Zheng YL, Liu WQ, Breen G, St. Clair D, He L. 2002. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Mol Psychiatry 7:100-103.
4. Imai K, Harada S, Kawanishi Y, Tachikawa H, Okubo T, Suzuki T. 2001. The (CTG), polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals. BMC psychiatry 1:1.
5. Li L, Huang GM, Banta AB, Deng Y, Smith T, Dong P, Friedman C, Chen L, Trask BJ, Spies T, Rowen L, Hood L. 1998. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene. Genomics 51:45-58.
6. Lutolf S, Radtke F, Aguet M, Suter U, Taylor V. 2002. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129:373-385.
7. McGinnis RE, Fox H, Yates P, Cameron LA, Barnes MR, Gray IC, Spurr NK, Hurko O, St. Clair D. 2001. Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nat Genet 28:128-129.
8. Schizophrenia Linkage Collaborative Group for Chromosome 3, 6, and 8. 1996. Additional support for schizophrenia linkage on chromosome 6 and 8: A multicenter study. Am J Med Genet 67:580-594.
9. Schneider S, Roessli D, Excoffier L. 2000. Arlequin ver. 2.000: A software for population genetics data analysis. Genetics and Biometry Laboratory, University of Geneva, Switzerland.
10. Sklar P, Schwab SG, Williams NM, Daly M, Schaffner S, Maier W, Albus M, Trixler M, Eichhammer P, Lerer B, Hallmayer J, Norton N, Williams H, Zammit S, Cardno AG, Jones S, McCarthy G, Milanova V, Kirov G, O'Donovan MC, Lander ES, Owen MJ, Wildenauer DB. 2001. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 28:126-128.
11. Skol AD, Young KA, Tsuang DW, Faraone SV, Haverstock SL, Bingham S, Prabhudesai S, Mena F, Menon AS, Yu CE, Rundell P, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Schellenberg GD, Tsuang MT. 2003. Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample. Am J Med Genet 118B:8-15.
12. Takahashi S, Cui YH, Kojima T, Han YH, Yu SY, Tanabe E, Yara K, Matsuura M, Matsushima E, Nakayama J, Arinami T, Shen YC, Faraone SV, Tsuang MT. 2003. Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples. Biol Psychiatry 54:129-135.
13. Ujike H, Takehisa Y, Takaki M, Tanaka Y, Nakata K, Takeda T, Kodama M, Fujiwara Y, Yamamoto A, Kuroda S. 2001. NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neurosci Lett 301:41-44.
14. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian NOTCH gene. Development 122:2251-2259.
15. Wang S, Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR. 1995. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10:41-46.
16. Wassink TH, Nopoulos P, Pietila J, Crowe RR, Andreasen NC. 2003. NOTCH4 and the frontal lobe in schizophrenia. Am J Med Genet 118B, 1-7.
17. Wei J, Hemmings GP. 2000. The NOTCH4 locus is associated with susceptibility to schizophrenia. Nat Genet 25, 376-377.
18. Zhang X, Wei J, Yu Y, Liu S, Shi J, Ju G, Yang J, Zhan D, Hemmings GP. A study of genetic association between NOTCH4 and schizophrenia in a Chinese population. Psychiatr Genet, in press.