Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos

Toxicology

Volumn 220, Issue 1, 2006, Pages 13-25

  Timchalk, C ^a   Poet, T S ^a   Kousba, A A ^b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b TargeGen Inc   (United States)

Author keywords

Age dependent sensitivity; Chlorpyrifos; Preweanling rat

Indexed keywords

2 HYDROXY 3,5,6 TRICHLORPYRIDINE; CHLORPYRIFOS; CHOLINESTERASE; CYTOCHROME P450; ORGANOPHOSPHATE INSECTICIDE; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; MALE; METABOLIC CAPACITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; TOXICOKINETICS; WEANING;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; ANIMALS, SUCKLING; BRAIN; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; INSECTICIDES; METABOLIC DETOXICATION, DRUG; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 32044468978     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.11.011     Document Type: Article

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