Genetic polymorphisms in human drug metabolic enzymes

Fundamental and Applied Toxicology

Volumn 40, Issue 1, 1997, Pages 1-14

  Miller, Mark Steven ^a   McCarver, Deborah Gail ^b   Bell, Douglas A ^c   Eaton, David L ^d   Goldstein, Joyce A ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ALCOHOL; ALCOHOL DEHYDROGENASE; CIGARETTE SMOKE; CYTOCHROME P450 ISOENZYME; GLUTATHIONE TRANSFERASE;

ALLELISM; CANCER RISK; DRUG METABOLISM; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HUMAN; NONHUMAN; PHENOTYPE; PRENATAL EXPOSURE; REVIEW;

ANIMALIA;

EID: 0031277472     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2382     Document Type: Review

References (136)

1. Abel E. L., Dintcheff B. A. Factors affecting the outcome of maternal alcohol exposure: II. Maternal age. Neurobehav. Toxicol. Teratol. 7:1985;263-266.
2. Alexandrie A. K., Sundberg M. I., Seidegard J., Tornling G., Rannug A. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis. 15:1994;1785-1790.
3. Ali-Osman F., Akande O., Antoun G., Mao J. X., Boulamwini J. Molecular cloning, characterization, and expression inEscherichia coli. J. Biol. Chem. 272:1997;10004-10012.
4. Ambrosone C. B., Freudenheim J. L., Graham S., Marshall J. R., Vena J. E., Brasure J. R., Laughlin R., Nemoto T., Michalek A. M., Harrington A. Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk. Cancer Res. 55:1995;3483-3485.
5. Anttila S., Luostarinen L., Hirvonen A., Elovaara E., Karjalainen A., Nurminen T., Hayes J. D., Vainio H., Ketterer B. Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: Association with GSTM1 polymorphism, smoking, and asbestos exposure. Cancer Res. 55:1995;3305-3309.
6. Anwar W. A., AbdelRahman S. Z., ElZein R. A., Mostafa H. M., Au W. W. Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients. Carcinogenesis. 17:1996;1923-1929.
7. Awasthi Y. C., Singh S.V., Ahmad H., Moller P. C. Immunohistochemical evidence for the expression of GST1, GST2, and GST3 gene loci for glutathione S-transferase in human lung. Lung. 195:1987;323-332.
8. Badawi A. F., Bell D. A., Hirvonen A., Kadlubar F. Role of aromatic amine acetyl transferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Cancer Res. 55:1995;5230-5237.
9. Bell D. A., Badawi A. F., Lang N. P., Ilett K. F., Kadlubar F., Hirvonen A. Poly morphism in the NAT1 polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue samples. Cancer Res. 55:1995a;5226-5229.
10. Bell D. A., Taylor J. A., Paulson D. F., Robertson C. N., Mohler J. L., Lucier G. W. Genetic risk and carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J. Natl. Cancer Inst. 85:1993;1159-1164.
11. Bell D. A., Thompson C. L., Taylor J., Miller C. R., Perera F., Hsieh L. L., Lucier G. W. Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: Application to glutathione transferase mu. Environ Health Perspect. 98:1992;113-117.
12. Bell D. A., Stephens E., Castranio T., Umbach D. M., Watson M., Deakin M., Elder J., Duncan H., Hendrickse C., Strange R. C. Polyadenylation polymorphism in the N-acetyl transferase gene 1 (NAT1) increases risk of colorectal cancer. Cancer Res. 55:1995b;3537-3542.
13. Bonthius D. J., Goodlett C. R., West J. R. Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration. Alcohol. 5:1988;209-214.
14. Bosron W. F., Li T.-K. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism. Hepatology. 6:1986;502-510.
15. Bosron W. F., Li T. K. Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme. 37:1987;19-28.
16. Bosron W. F., Magnes L. J., Li T. K. Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase. Biochemistry. 22:1983a;1852-1857.
17. Indianapolis2. Biochem. Genet. 21:1983b;735-744.
18. Brockmoller J., Cascorbi I., Kerb R., Roots I. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res. 56:1996;3915-3925.
19. Brockmoller J., Kerb R., Drakoulis N., Nitz M., Roots I. Genotype and phenotype of glutathione S-transferase class isoenzymes mu and psi in lung cancer patients and controls. Cancer Res. 53:1993;1004-1011.
20. Brockmoller J., Kerb R., Drakoulis N., Staffeldt B., Roots I. Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case control study. Cancer Res. 53:1994;1004-1011.
21. Brøsen K., deMorais S. M. F., Meyer U. A., Goldstein J. A. A multifamily study on the relationship betweenCYP2C19S. Pharmacogenetics. 5:1995;312-317.
22. Burnell J. C., Li T. K., Bosron W. F. Purification and steady-state kinetic characterization of human liver β3β3 alcohol dehydrogenase. Biochemistry. 28:1989;6810-6815.
23. Caporaso N. Commentary: Genetic susceptibility and the common cancers. Biomarkers. 1:1996;174-177.
24. Chen C. J., Yu M. W., Liaw Y. F., Wang L. W., Chiamprasert S., Matin F., Hirvonen A., Bell D. A., Santella R. M. Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. Am. J. Hum. Genet. 59:1996b;128-134.
25. Chen C. L., Liu Q., Relling M. V. Simultaneous characterization of glutathione S-transfersase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks. Pharmacogenetics. 6:1996c;187-191.
26. Chen C., Madeleine M. M., Lubinski C., Weiss N. S., Tickman E. W., Daling J. R. Glutathione S-transferase M1 genotypes and the risk of analy cancer: A population-based case-control study. Cancer Epidem. Biomarkers Prev. 5:1996a;985-991.
27. Chen H., Sandler D., Taylor J., Shore D., Liu E., Bloomfield C., Bell D. Increased risk for myelodysplastic syndromes in individuals with glutatione transferase theta 1 (GSTT1. Lancet. 347:1996d;295-297.
28. Chenevix T.-G., Young J., Coggan M., Board P. Glutathione S-transferase M1 and T1 polymorphisms: Susceptibility to colon cancer and age of onset. Carcinogenesis. 16:1995;1655-1657.
29. Cheng T. J., Christiani D. C., Wiencke J. K., Wain J. C., Xu X., Kelsey K. T. Comparison of sister chromatid exchange frequency in peripheral lymphocytes in lung cancer cases and controls. Mutat Res. 348:1995;75-82.
30. Chernoff G. F. The fetal alcohol syndrome in mice: Maternal variables. Teratology. 22:1980;71-75.
31. Conney A. H. Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev. 19:1967;317-366.
32. Conney A. H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res. 42:1982;4875-4917.
33. Daly A. K., Thomas D. J., Cooper J., Pearson W. R., Neal W. R., Idle J. R. Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. Br. Med. J. 307:1993;481-482.
34. Deakin M., Elder J., Hendrickse C., Peckham D., Baldwin D., Pantin C., Wild N., Leopard P., Bell D. A., Jones P., Duncan H., Brannigan K., Alldersea J., Fryer A. A., Strange R. C. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: Studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis. 17:1996;881-884.
35. de Morais S. M. F., Wilkinson G. R., Blaisdell J., Nakamura U. A., Meyer U. A., Goldstein J. A. Identification of a new genetic defect responsible for the polymorphism ofS. Mol. Pharmacol. 46:1994a;595-598.
36. de Morais S. M. F., Wilkinson G. R., Blaisdell J., Nakamura K., Meyer U. A., Goldstein J. A. The major defect responsible for the polymorphism ofS. J. Biol. Chem. 269:1994b;15419-15422.
37. de Morais S. M. F., Goldstein J. A., Xie H.-G., Huang S.-L., Lu Y. P., Xia H., Xiao Z.-S., Ile N., Zhou H. H. Genetic analysis of theS. Clin. Pharm. Ther. 58:1995;404-412.
38. dErrico A., Taioli E., Chen X., Vineis P. Genetic metabolic polymorphisms and the risk of cancer: A review of the literature. Biomarkers. 1:1996;149-173.
39. Di Ilio C., DelBoccio G., Aceto A., Casaccia R., Mucilli F. Elevation of glutathione S-transferase activity in human lung tumor. Carcinogenesis. 9:1988;355-340.
40. Ehrig T., Bosron W. F., Li T. K. Alcohol and aldehyde dehydrogenase. Alcohol Alcohol. 25:1990;105-116.
41. Elexpuru C.-J., Buxton N., Kandula V., Dias P. S., Campbell D., McIntosh J., Broome J., Jones P., Inskip A., Alldersea J. Susceptibility to astrocytoma and meningioma: Influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res. 55:1995;4237-4239.
42. R. J. Ferguson, S. M. F. de Morais, S. Benhamou, C. Bouchard, J. Blaisdell, G. Ibeanu, G.R. Wilkinson, T. C. Sarich, J. M. Wright, P. Dayer, J. A. Goldstein, A novel defect in humanCYP2C19:, J. Pharmacol. Exp. Ther.
43. Golden N. L., Sokol R. J., Kuhnert B. R., Bottoms S. Maternal alcohol use and infant development. Pediatrics. 70:1982;931-934.
44. Goldstein J. A., Blaisdell J. Genetic Tests which identify the principle defects inCYP2C19. Methods in Enzymology: Cytochrome P450. 1996;Academic Press, San Diego. p. 210-217.
45. Goldstein J. A., de Morais S. M. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics. 4:1994;285-299.
46. Goldstein J. A., Faletto M. B., Romkes-Sparks M., Sullivan T, Raucy J., Kitareewan S., Lasker J. M., Ghanayem B. Evidence for that CYP2C19 is the major (S. Biochemistry. 33:1994;1743-1752.
47. Goldstein J. A., Ishizaki T., Chiba K., de Morais S. M. F., Bell D., Krahn P. D., Price Evans D. Frequencies of the defectiveCYP2C19. Pharmacogenetics. 7:1997;59-64.
48. Gonzalez F. J. The molecular biology of cytochrome P-450s. Pharmacol. Rev. 40:1988;243-288.
49. Goodlett C. R., Marcussen B. L., West J.R. A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol. 7:1990;107-114.
50. Guengerich F. P., Thier R., Persmark M., Taylor J. B., Pemble S. E., Ketterer B. Conjugation of carcinogens by theta class glutathione s-transferases: Mechanisms and relevance to variations in human risk. Pharmacogenetics. 5:1995;S103-S107.
51. Hand P. A., Inskip A., Gilford J., Alldersea J., ElexpuruCamiruaga J., Hayes J. D., Jones P. W., Strange R. C., Fryer A. A. Allelism at the glutathione S-transferase GSTM3 locus: Interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis. 17:1996;1919-1922.
52. Harada S., Misawa S., Nakamura T., Tanaka N., Ueno E., Mutzumi N. Detection of GST1 gene deletion by polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Hum. Genet. 90:1992;62-64.
53. Harries L. W., Stubbins M. J., Forman D., Howard G. C. W., Wolf C. R. Identification of genetic polymorphisms at the glutathione S-transferase pi locus and association with suceptibility to bladder, testicular and prostate cancer. Carcinogenesis. 18:1997;641-644.
54. Hayashi S., Watanabe J., Kawajiri K. High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes. Jpn. J. Cancer Res. 83:1992;866-870.
55. Hayes J. D., Pulford D. J. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30:1995;445-600.
56. Heagerty A., Fitzgerald D., Smith A., Bowers B., Jones P., Fryer A., Zhao L., Alldersea J., Strange R. C. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet. 343:1994;266-268.
57. Heagerty A., Smith A., English J., Lear J., Perkins W., Bowers B., Jones P., Gilford J., Alldersea J., Fryer A., Strange R. C. Susceptibility to multiple cutaneous basal cell carcinomas: Significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. Br. J. Cancer. 73:1996;44-48.
58. Heckbert S. R., Weiss N. S., Hornung S. K., Eaton D. L., Motulsky A. G. Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers. J. Natl. Cancer Inst. 84:1992;414-422.
59. Hirvonen A., Husgafvel P.-K., Anttila S., Vainio H. The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis. 14:1993;1479-1481.
60. Hirvonen A., Nylund L., Kociba P., Husgafvel P.-K., Vainio H. Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers [published erratum appears in Carcinogenesis15. Carcinogenesis. 15:1994;813-815.
61. Hsieh L. L., Huang R. C., Yu M. W., Chen C. J., Liaw Y. F. L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers. Cancer Lett. 103:1996;171-176.
62. Hughes N., McQueen K., Janezic S., Jewett M., Castranio T., Bell D. A., Grant D. M. Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective functions using p-aminosalicylate as an in vivo/in vitro probe. Pharmacogenetics. 6:1997.
63. Idle J. R. Is environmental carcinogenesis modulated by host polymorphism? Mutat. Res. 247:1991;259-266.
64. Inskip A., Elexperu-Camiruaga J., Buxton N., Dias P. S., MacIntosh J., Campbell D., Jones P. W., Yengi L., Talbot J. A., Strange R. C., Fryer A. A. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: Evidence for linkage with GSTM1*A. Biochem. J. 312:1995;713-716.
65. Jahnke V., Matthias C., Fryer A., Strange R. Glutathione S-transferase and cytochrome P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. Am. J. Surg. 172:1996;671-673.
66. Jernstrom B., Dock L., Hall M., Mannervik B., Tahir M. K., Grover P. L. Glutathione transferase catalyzed conjugation of benzo(a)pyrene 7,8-diol 9,10-epoxide with glutathione in human skin. Chem-Biol. Interact. 70:1989;173-180.
67. Jornvall H., Hoog J. O. Nomenclature of alcohol dehydrogenases. Alcohol Alcohol. 30:1995;153-161.
68. Kato S., Bowman E. D., Harrington A. M., Blomeke B., Shields P. G. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo [see comments]. J. Natl. Cancer Inst. 87:1995;902-907.
69. Kato S., Onda M., Matsukura N., Tokunaga A., Matsuda N., Yamashita K., Shields P. G. Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study. Cancer. 77:1996;1654-1661.
70. Katoh T. Application of molecular biology to occupational health field - The frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer. Sangyo Ika Daigaku Zasshi. 17:1995;271-278.
71. Katoh T., Inatomi H., Nagaoka A., Sugita A. Cytochrome P4501A1 gene polymor phism and homozygous deletion of the glutathione S-transferase M1 gene in urothelial cancer patients. Carcinogenesis. 16:1995;655-657.
72. Katoh T., Nagata N., Kuroda Y., Itoh H., Kawahara A., Kuroki N., Ookuma R., Bell D. A. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis. 17:1996;1855-1859.
73. Kawajiri K., Eguchi H., Nakachi K., Sekiya T., Yamamoto M. Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer. Cancer Res. 56:1996;72-76.
74. Kawajiri K., Watanabe J., Eguchi H., Hayashi S. Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. Pharmacogenetics. 1995;S70-S73.
75. Kihara M., Kihara M., Noda K. Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis. 16:1995a;2331-2336.
76. Kihara M., Noda K., Kihara M. Distribution of GSTM1 null genotype in relation to gender, age and smoking status in Japanese lung cancer patients. Pharmacogenetics. 5:1995b;S74-S79.
77. Koskelo K., Valmet E., Tenhunen R. Purification and characterization of an acid glutathione S-transferase from human lung. Scand. J. Clin. Lab Invest. 41:1981;683-689.
78. Kumar A., Das B. C., Sharma J. K. Bam. Hum. Genet. 94:1994;107-108.
79. Lafuente A., Giralt M., Cervello I., Pujol F., Mallol J. Glutathione-S-transferase activity in human superficial transitional cell carcinoma of the bladder. Comparison with healthy controls. Cancer. 65:1990;2064-2068.
80. Lafuente A., Pujol F., Carretero P., Villa J. P., Cuchi A. Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers. Cancer Lett. 68:1993;49-54.
81. Lafuente A., Zakahary M. M., ElAziz M. A. A., Ascaso C., Lafuente M. J., Trias M., Carretero P. Influence of smoking in the glutathione-S-transferase M1 deficiency-associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt. Br. J. Cancer. 74:1996;836-838.
82. Lang N., Butler M. A., Massengill M. L., Stotts R. C., Hauer-Jensen M., Kadlubar F. F. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol. Biomarkers Prev. 3:1994;675-682.
83. Lear J. T., Heagerty A. H. M., Smith A., Bowers B., Payne C. R., Smith C. A. D., Jones P. W., Gilford J., Yengi L., Alldersea J., Fryer A. A., Strange R. C. Multiple cutaneous basal cell carcinomas: Glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis. 17:1996;1891-1896.
84. Lee E. J., Wong J. Y., Yeoh P. N., Gong N. H. Glutathione S transferase-theta (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore. Pharmacogenetics. 5:1995;332-334.
85. Lin H. J., Han C. Y., Bernstein D. A., Hsiao W., Lin B. K., Hardy S. Ethnic distribution of the glutathione S-transferase M1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer. Carcinogenesis. 15:1993;1077-1081.
86. Lin H. J., Han C. Y., Lin B. K., Hardy S. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics. 4:1994;125-134.
87. Liu L., Wang L. H. Correlation between lung cancer prevalence and activities of aryl hydrocarbon hydroxylase and glutathione S-transferase in human lung tissues. Biomed. Environ. Sci. 1:1988;277-282.
88. London S. J., Daly A. K., Cooper J., Navidi W. C., Carpenter C. L., Idle J. R. Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California. J. Natl. Cancer Inst. 87:1995;1246-1253.
89. Mannervik B., Awasthi Y. C., Board P. G., Hayes J.-D., DiIlio C., Ketterer B., Listowsky I., Morgenstern R., Muramatsu M., Pearson W. R., Pickett C. B., Sato K., Widersten M., Wolf C. R. Nomenclature for human glutathione transferases. Biochem. J. 282:1992;305-306.
90. McCarver D. G., Thomasson H. R., Martier S. S., Sokol R. J., Li T.-K. Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. J. Pharmacol. Exp. Ther. 1998.
91. McGlynn K. A., Rosvold E. A., Lustbader E. D., Hu Y., Clapper M. L., Zhou T., Wild C. P., Xia X. L., Baffoe-Bonnie A., Ofori-Adejei D., Chen G. C., London W. T., Shen F. M., Buetow K. H. Susceptibility to hepatocellular carcinoma is associated with genetic variation in enzymatic detoxification of aflatoxin B1. Proc. Natl. Acad. Sci. USA. 92:1995;2384-2387.
92. McWilliams J. E., Sanderson B. J., Harris E. L., Richert B.-K. E., Henner W. D. Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 4:1995;589-594.
93. Mezey E. Ethanol metabolism and ethanol-drug interactions. Biochem. Pharmacol. 25:1976;869-875.
94. Nazar S.-V., Motulsky A. G., Eaton D. L., White E., Hornung S. K., Leng Z. T., Stapleton P., Weiss N. S. The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma. Cancer Res. 53:1993;2313-2318.
95. Nebert D. W. Role of genetics and drug metabolism in human cancer risk. Mutat. Res. 247:1991;267-281.
96. Nelson H. H., Wiencke J. K., Christiani D. C., Cheng T. J., Zuo Z. F., Schwartz B. S., Lee B. K., Spitz M. R., Wang M., Xu X. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis. 16:1995;1243-1245.
97. Okkels H., Sigsgaard T., Wolf H., Autrup H. Glutathione S-transferase mu as a risk factor in bladder tumours. Pharmacogenetics. 6:1996;251-256.
98. Partridge C. A., Dao D. D., Awasthi Y. C. Glutathione S-transferase of lung: Purification and characterization of human lung glutathione S-transferases. Lung. 162:1984;27-36.
99. Pemble S., Schroeder K. R., Spencer S. R., Meyer D. J., Hallier E., Bolt H. M., Ketterer B., Taylor J. B. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 300:1994;271-276.
100. 1exoendo. Chem. Res. Toxicol. 5:1992;470-478.
101. Rettie A., Wienkers L. C., Gonzalez F. J., Trager W. F., Korzekwa K. R. Impaired (S. Pharmacogenetics. 4:1994;39-42.
102. Robertson I. G. C., Guthenberg C., Mannervik B., Jernstrom B. Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7b, 8a-dihydroxy-9a, 10a-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Cancer Res. 46:1986;2220-2224.
103. Rothman N., Hayes R. B., Zenser T. V., DeMarini D. M., Bi W. F., Hirvonen A., Talaska G., Bhatnagar V. K., Caporaso N. E., Brooks L. R., Lakshmi V. M., Feng P. W., Kashyap S. K., You X. J., Eischen B. T., Kashyap R., Shelton M. L., Hsu F. F., Jaeger M., Parikh D. J., Davis B. B., Yin S. N., Bell D. A. The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts. Cancer Epidemiol. Biomarkers Prev. 5:1996;979-983.
104. Rothman N., Shields P. G., Poirier M. C., Harrington A. M., Ford D. P., Strickland P. T. The impact of glutathione s-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-DNA adduct levels in humans. Mol Carcinogenesis. 14:1995;63-68.
105. Sarhanis P., Redman C., Perrett C., Brannigan K., Clayton R. N., Hand P., Musgrove C., Suarez V., Jones P., Fryer A. A., Farrell W. E., Strange R. C. Epithelial ovarian cancer: Influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. Br. J. Cancer. 74:1996;1757-1761.
106. Sarich T., Kalhorn T., Magee S., AlSayeh F., Adams S., Slattery J., Goldstein J., Nelson S., Wright J. The effect of omeprazole pretreatment on acetaminophen methabolism in rapid and slow metabolizers ofS. Clin. Pharm. Ther. 62:1997;21-28.
107. Scarpato R., Migliore L., Hirvonen A., Falck G., Norppa H. Cytogenetic monitoring of occupational exposure to pesticides: Characterization of GSTM1, GSTT1, and NAT2 genotypes. Environ. Mol. Mutagen. 27:1996;263-269.
108. Seidegard J., Pero R. W. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet. 69:1985;66-68.
109. Seidegard J., DePierre J. W., Pero R. W. Hereditary interindividual differences in the glutathione transferase activity towards trans-stilbene oxide in resting human mononuclear leukocytes are due to a particular isozyme(s). Carcinogenesis. 6:1985;1211-1216.
110. Seidegard J., Pero R. W., Stille B. Identification of the trans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes and in liver as GST1. Biochem. Genet. 27:1989;253-261.
111. Seidegard J., Pero R. W., Miller D. G., Beattie E. J. A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis. 7:1986;751-753.
112. Seidegard J., Vorachek W. R., Pero R. W., Pearson W. R. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. USA. 85:1988;7293-7297.
113. Sokol R., Ager J., Martier S., Debanne S., Ernhart C., Kuzma J., Miller S. I. Significant determinants of susceptibility to alcohol teratogenicity. Ann. NY Acad. Sci. 477:1986;87-102.
114. Sokol R. J., Miller S. I., Reed G. Alcohol abuse during pregnancy: An epidemiologic study. Alcohol Clin. Exp. Res. 4:1980;135-145.
115. Sorsa M., OstermanGolkar S., Peltonen K., Saarikoski S. T., Sram R. Assessment of exposure to butadiene in the process industry. Toxicology. 113:1996;77-83.
116. Spielberg S., McCrea J., Cribb A., Rushmore T., Waldman S., Bjornsson T., Lo M. W., Goldberg M. A mutation inCYP2C9. Clin. Pharm. Ther. 59:1996;215.
117. Strange R. C., Matharoo B., Faulder G. C., Jones P., Cotton W., Elder J. B., Deakin M. The human glutathione S-transferase: A case control study of the incidence of the GST 1 0 phenotype in patients with adenocarcinoma. Carcinogenesis. 12:1991;25-28.
118. Streissguth A. P., Barr H. M., Martin D. C., Herman C. S. Effects of maternal alcohol, nicotine, and caffeine use during pregnancy on infant mental and motor development at eight months. Alcohol Clin. Exp. Res. 4:1980;152-164.
119. 359. Pharmacogenetics. 6:1996;341-349.
120. Suzuki T., Coggan M., Shaw D. C., Board P. G. Electrophoretic and immunological analysis of human glutathione S-transferase isoenzymes. Ann. Hum. Genet. 51:1987;95-106.
121. Taylor J. A., Umbach D., Stephens E., Paulson D., Robertson D., Mohler J., Bell D. A. The role of N-acetylation polymorphisms at NAT1 and NAT2 in smoking-associated bladder cancer. Proc. Am. Assoc. Cancer Res. 36:1995;1681.
122. ToFigueras J., Gene M., GomezCatalan J., Galan C., Firvida J., Fuentes M., Rodamilans M., Huguet E., Estape J., Corbella J. Glutathione-S-transferase M1 and codon 72 p53 polymorphisms in a Northwestern mediterranean population and their relation to lung cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 5:1996;337-342.
123. Trizna Z., Clayman G. L., Spitz M. R., Briggs K. L., Goepfert H. Glutathione s-transferase genotypes as risk factors for head and neck cancer. Am. J. Surg. 170:1995;499-501.
124. van Poppel G., Verhagen H., van t'Veer P., van Bladeren P. J. Markers for cytogenetic damage in smokers: associations with plasma antioxidants and glutathione S-transferase mu. Cancer Epidemiol. Biomarkers Prev. 2:1993;441-447.
125. Warwick A. P., Redman C. W., Jones P. W., Fryer A. A., Gilford J., Alldersea J., Strange R. C. Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. Br. J. Cancer. 70:1994;704-708.
126. Wiencke J. K., Pemble S., Ketterer B., Kelsey K. T. Gene deletion of glutathione S-transferase theta: Correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol. Biomarkers Prev. 4:1995;253-259.
127. Wilkinson G. R., Guengerich F. P., Branch R. A. Genetic polymorphism ofS. Pharmacol. Ther. 43:1989;53-76.
128. Wrighton S. A., Stevens J. C., Becker G. W., VandenBranden M. Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 andS. Arch. Biochem. Biophys. 306:1993;240-245.
129. Xiao Z.-S., Goldstein J. A., Xie H. G., Blaisdell J., Wang W., Jiang C. H., Yan F. X., He N., Huang S. L., Xu Z. H., Zhou H. H. Differences in the incidence of the CYP2C19 polymorphism affecting theS. Pharmacol. Exper. Ther. 281:1997;604-609.
130. Yengi L., Inskip A., Gilford J., Alldersea J., Bailey L., Smith A., Lear J. T., Heagerty A. H., Bowers B., Hand P., Hayes J. D., Jones P. W., Strange R. C., Fryer A. A. Polymorphism at the glutathione S-transferase locus GSTM3: Interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Res. 56:1996;1974-1977.
131. Yu M. C., Ross R. K., Chan K. K., Henderson B. E., Skipper P. L., Tannenbaum S. R., Coetzee G. A. Glutathione S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in white, black and Asian smokers and non-smokers. Cancer Epidemiol. Biomarkers Prev. 4:1995a;861-864.
132. Yu M. W., Gladek-Yarborough A., Chiamprasert S., Santella R. M., Liaw Y. F., Chen C. J. Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. Gastroenterology. 109:1995b;1266-1273.
133. Zhao B., Lee E. J., Wong J. Y., Yeoh P. N., Gong N. H. Frequency of mutant CYP1A1, NAT2 and GSTM1 alleles in normal Indians and Malays. Pharmacogenetics. 5:1995;275-280.
134. Zhong S., Howie A. F., Ketterer B., Taylor J., Hayes J. D., Beckett G. J., Wathen C. G., Wolf C. R., Spurr N. K. Glutathione S-transferase mu locus: Use of genotyping and phenotyping assays to assess association with lung cancer susceptibility. Carcinogenesis. 12:1991;1533-1537.
135. Zhong S., Wyllie A. H., Barnes D., Wolf C. R., Spurr N. K. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 14:1993;1821-1824.
136. Zimniak P., Nanduri B., Pikula S., Bandorowicz-Pikula J., Singhal S. S., Srivastava S. K., Awasathi S., Awasathi Y. C. Naturally occurring human glutathione S-transfersase GSTP1-1 isoforms with isoleucine ad valine in position 104 differ in enzymatic properties. Eur. J. Biochem. 224:1994;893-899.