Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer

Anticancer Research

Volumn 27, Issue 4 B, 2007, Pages 2189-2195

  Ozawa, Hiroyuki ^a,b   Matsunaga, Tatsuo ^a   Kamiya, Kazusaku ^a   Tokumaru, Yutaka ^a   Fujii, Masato ^a   Tomita, Toshiki ^b   Ogawa, Kaoru ^b  

^a NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Connexin 26; Connexin 30; Head and neck cancer; Tumor suppressor

Indexed keywords

CONNEXIN 26; CONNEXIN 30; INVOLUCRIN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER LOCALIZATION; CANCER TISSUE; CARCINOGENESIS; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MUCOSA; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CONNEXINS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; MOUTH MUCOSA;

EID: 34547824547     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Evans WH and Martin PEM: Gap junctions: structure and function (Review). Mol Membr Biol 19: 121-136, 2002.
2. Janssen-Timmen U, Traub O, Dermietzel R, Rabes HM and Willecke K: Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody. Carcinogenesis 7: 1475-1482, 1986.
3. Wilgenbus KK, Kirkpatrick CJ, Knuechel R, Willecke K and Traub O: Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer 51: 522-529, 1992.
4. Jinn Y, Ichioka M and Marumo F: Expression of connexin32 and connexin43 gap junction proteins and E-cadherin in human lung cancer. Cancer Lett 127: 161-169, 1998.
5. Schneider B, Teschner M, Sudermann T, Pikula B and Lautermann J: Expression of gap junction proteins (connexin 26, 30, 32, 43) in normal mucosa, hyperkeratosis and carcinoma of the human larynx. ORL J Otorhinolaryngol Relat Spec 64: 324-329, 2002.
6. Zhu D, Kidder GM, Caveney S and Naus CC: Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein. Proc Natl Acad Sci USA 89: 10218-10221, 1992.
7. Goldberg GS, Becheberger JF, Tajima Y, Merritt M, Omori Y, Gawinowicz MA, Narayanan R, Tan Y, Sanai Y, Yamasaki H, Naus CC, Tsuda H and Nicholson BJ: Connexin 43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells. Cancer Res 60: 6018-6026, 2000.
8. Seul KH, Kang KY, Lee KS, Kim SH and Beyer EC: Adenoviral delivery of human connexin 37 induces endothelial cell death through apoptosis. Biochem Biophys Res Commun 319: 1144-1151, 2004.
9. Moorby C and Patel M: Dual functions for connexins: Cx43 regulates growth independently of gap junction formation. Exp Cell Res 271: 238-248, 2001.
10. Zhang YW, Nakayama K, Nakayama K and Morita I: A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Cancer Res 63: 1623-1630, 2003.
11. Dang X, Doble BW and Kardami E: The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Mol Cell Biochem 242: 35-38, 2003.
12. Mesnil M, Krutovskikh V, Piccoli C, Elfgang C, Traub O, Willecke K and Yamasaki H: Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res 55: 629-639, 1995.
13. Princen F, Robe P, Gros D, Jarry-Guichard T, Gielen J, Merville MP and Bours V: Rat gap junction connexin-30 inhibits proliferation of glioma cell lines. Carcinogenesis 22: 507-513, 2001.
14. Hara A, Murata T, Uemura R, Miura T, Fukui K, Matsukawa H, Kasiwagi K, Ito T, Yoshioka M and Hibi T: Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis. J Gastroenterol 34: 1-6, 1999.
15. Jamieson S, Going JJ, D'Arcy R and George WD: Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumors. J Pathol 184: 37-43, 1998.
16. Kanczuga-Koda L, Sulkowski S, Koda M, Skrzydlewska E and Sulkowska M: Connexin 26 correlates with Bcl-xl and Bax proteins expression in colorectal cancer. World J Gastroenterol 11: 1544-1548, 2005.
17. Huang RP, Fan Y, Hossain MZ, Peng A and Zeng ZL and Boynton AL: Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res 58: 5089-5096, 1998.
18. Omori Y and Yamasaki H: Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner. Int J Cancer 78: 446-453, 1998.
19. Qin H, Shao Q, Curtis H, Galipeau J, Belliveau DJ, Wang T, Alaoui-Jamali MA and Laird DW: Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem 277: 29132-29138, 2002.
20. Kalra J, Shao Q, Qin H, Thomas T, Alaoui-Jamali MA and Laird DW: Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis 27: 2528-2537, 2006.
21. Kalvelyte A, Imbrasaite A, Bukauskiene A, Verselis VK and Bukauskas FF: Connexins and apoptotic transformation. Biochem Pharmacol 66: 1661-1672, 2003.
22. Arita K, Akiyama M, Tsuji Y, McMillan JR, Eady RA and Shimizu H: Changes in gap junction distribution and connexin expression pattern during human fetal skin development. J Histochem Cytochem 50: 1493-1500, 2002.
23. Hirschi KK, Xu CE, Tsukamoto T and Sager R: Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ 7: 861-870, 1996.
24. Lucke T, Choudhry R, Thom R, Selmer IS, Burden AD and Hodgins MB: Up-regulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium. J Invest Dermatol 112: 354-361, 1999.
25. Wiszniewski L, Limat A, Saurat JH, Meda P and Salomon D: Differential expression of connexins during stratification of human keratinocytes. J Invest Dermatol 115: 278-285, 2000.