Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis

Biochemical and Biophysical Research Communications

Volumn 319, Issue 4, 2004, Pages 1144-1151

  Seul, Kyung H ^a   Kang, Keum Y ^a   Lee, Kyung S ^b   Kim, Suhn H ^b   Beyer, Eric C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

Apoptosis; Blood vessels; Cell communication; Endothelial cells; Fap junction

Indexed keywords

ADENOVIRUS VECTOR; BIOTIN DERIVATIVE; CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; GLYCYRRHETINIC ACID DERIVATIVE; LUCIFER YELLOW;

APOPTOSIS; ARTICLE; CELL COMMUNICATION; CELL DEATH; CELL FUNCTION; CELL GROWTH; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXPERIMENTAL INFECTION; GAP JUNCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; CONNEXINS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPITHELIAL CELLS; GAP JUNCTIONS; GENE TRANSFER TECHNIQUES; GLYCYRRHETINIC ACID; HUMANS; MICE; NEUROBLASTOMA; RATS;

ADENOVIRIDAE;

EID: 2942515209     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.05.097     Document Type: Article

References (29)

1. Larson D.M., Haudenschild C.C., Beyer E.C. Gap junction messenger RNA expression by vascular wall cells. Circ. Res. 66:1990;1074-1080
2. Van Rijen H., van Kempen M.J., Analbers L.J., Rook M.B., van Ginneken A.C., Gros D., Jongsma H.J. Gap junctions in human umbilical cord endothelial cells contain multiple connexins. Am. J. Physiol. 272:1997;C117-C130
3. Bruzzone R., Haefliger J.A., Gimlich R.L., Paul D.L. Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Mol. Biol. Cell. 4:1993;7-20
4. Gabriels J.E., Paul D.L. Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ. Res. 83:1998;636-643
5. Ko Y.S., Yeh H.I., Rothery S., Dupont E., Coppen S.R., Severs N.J. Connexin make-up of endothelial gap junctions in the rat pulmonary artery as revealed by immunoconfocal microscopy and triple-label immunogold electron microscopy. J. Histochem. Cytochem. 47:1999;683-692
6. Kwak B.R., Pepper M.S., Gros D.B., Meda P. Inhibition of endothelial wound repair by dominant negative connexin inhibitors. Mol. Biol. Cell. 12:2001;831-845
7. Liao Y., Day K.H., Damon D.N., Duling B.R. Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc. Natl. Acad. Sci. USA. 98:2001;9989-9994
8. Kwak B.R., Mulhaupt F., Veillard N., Gros D.B., Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22:2002;225-230
9. Yasui K., Kada K., Hojo M., Lee J.K., Kamiya K., Toyama J., Opthof T., Kodama I. Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myocytes. Cardiovasc. Res. 48:2000;68-76
10. Raff M.C. Social controls on cell survival and cell death. Nature. 356:1992;397-400
11. Lin J.H., Weigel H., Cotrina M.L., Liu S., Bueno E., Hansen A.J., Hansen T.W., Goldman S., Nedergaard M. Gap-junction-mediated propagation and amplification of cell injury. Nat. Neurosci. 1:1998;494-500
12. Hellmann P., Grummer R., Schirrmacher K., Rook M., Traub O., Winterhager E. Transfection with different connexin genes alters growth and differentiation of human choriocarcinoma cells. Exp. Cell Res. 246:1999;480-490
13. Meier P., Finch A., Evan G. Apoptosis in development. Nature. 407:2000;796-801
14. Huang R.P., Hossain M.Z., Huang R., Gano J., Fan Y., Boynton A.L. Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells. Int. J. Cancer. 92:2001;130-138
15. Krutovskikh V.A., Piccoli C., Yamasaki H. Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene. 21:2002;1989-1999
16. Taimor G. Cardiac gap junctions: good or bad? Cardiovasc. Res. 48:2000;8-10
17. Andrade-Rozental A.F., Rozental R., Hopperstad M.G., Wu J.K., Vrionis F.D., Spray D.C. Gap junctions: the kiss of death and the kiss of life. Brain Res. Brain Res. Rev. 32:2000;308-315
18. Simon A.M., McWhorter A.R. Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. Dev. Biol. 251:2002;206-220
19. Brink P.R., Cronin K., Banach K., Peterson E., Westphale E.M., Seul K.H., Ramanan S.V., Beyer E.C. Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37. Am. J. Physiol. 273:1997;C1386-C1396
20. Larson D.M., Seul K.H., Berthoud V.M., Lau A.F., Sagar G.D., Beyer E.C. Functional expression and biochemical characterization of an epitope-tagged connexin37. Mol. Cell. Biol. Res. Commun. 3:2000;115-121
21. Seul K.H., Beyer E.C. Heterogeneous localization of connexin40 in the renal vasculature. Microvasc. Res. 59:2000;140-148
22. Valiunas V., Gemel J., Brink P.R., Beyer E.C. Gap junction channels formed by coexpressed connexin40 and connexin43. Am. J. Physiol. Heart Circ. Physiol. 281:2001;H1675-H1689
23. Martinez A.D., Hayrapetyan V., Moreno A.P., Beyer E.C. Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ. Res. 90:2002;1100-1107
24. Fick J., Barker II F.G., Dazin P., Westphale E.M., Beyer E.C., Israel M.A. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc. Natl. Acad. Sci. USA. 92:1995;11071-11075
25. Veenstra R.D., Wang H.Z., Beblo D.A., Chilton M.G., Harris A.L., Beyer E.C., Brink P.R. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ. Res. 77:1995;1156-1165
26. Cao F., Eckert R., Elfgang C., Nitsche J.M., Snyder S.A., Hulser D.F., Willecke K., Nicholson B.J. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes. J. Cell Sci. 111(Pt. 1):1998;31-43
27. Puljung M.C., Berthoud V.M., Beyer E.C., Hanck D.A. Inhibition of human Connexin37 hemichannels by extracellular divalent cations. Biophys. J. 80:2001;126d
28. Plotkin L.I., Manolagas S.C., Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J. Biol. Chem. 277:2002;8648-8657
29. Lin J.H., Yang J., Liu S., Takano T., Wang X., Gao Q., Willecke K., Nedergaard M. Connexin mediates gap junction-independent resistance to cellular injury. J. Neurosci. 23:2003;430-441