Expression of MUC2 in gastric carcinomas and background mucosae

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 8, 2007, Pages 1336-1343

  Lee, Hae Wan ^a   Yang, Dae H ^a   Kim, Hong K ^a   Lee, Bong H ^a   Choi, Kyung C ^a   Choi, Young H ^a   Park, Young E ^a  

^a Hallym University   (South Korea)

Author keywords

Gastric carcinoma; Intestinal metaplasia; MUC2; Mucin expression

Indexed keywords

MUCIN 2;

ADENOCARCINOMA; ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE METAPLASIA; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; STOMACH CARCINOMA; STOMACH MUCOSA;

EID: 34547778463     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.04939.x     Document Type: Article

References (41)

1. Corrales RM, Galarreta DJ, Herreras JM, Calonge M, Chaves FJ. Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes. Arch. Soc. Esp. Oftalmol. 2003 78 : 375 81.
2. Dekker J, Rossen JWA, Buller HA, Einerhand AWC. The MUC family: an obituary. Trends Biochem. Sci. 2002 27 : 126 31.
3. Gum JR Crawley SC, Hicks JW, Szymkowski DE, Kim YS. MUC17, a novel membrane-tethered mucin. Biochem. Biophys. Res. Commun. 2003 291 : 466 75.
4. Ho SB, Shekels LL, Toribara NW et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995 55 : 2681 90.
5. Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simoes M. Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. Int. J. Cancer 1998 79 : 402 10.
6. Audie JP, Janin A, Porchet N, Copin MC, Gossssselin B, Aubert JP. Expression of human mucin genes in respiratory, digestive, and reproductive tract as ascertained by in situ hybridization. J. Histochem. Cytochem. 1993 43 : 1479 85.
7. Chang SK, Dohrman AF, Basbaum CB et al. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 1994 107 : 28 36.
8. Reis CA, David L, Correa P et al. Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res. 1999 59 : 1003 7.
9. Taylor KL, Mall AS, Barnard RA, Ho SB, Cruse JP. Immunohistochemical detection of gastric mucin in normal and disease states. Oncol. Res. 1998 10 : 465 73.
10. Bresalier RS, Niv Y, Byrd JC et al. Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of human colon cancer metastasis. J. Clin. Invest. 1991 87 : 1037 45.
11. Kojima N, Handa K, Newman W, Hakomori S. Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelet by blocking O-glycosylation of these cells. Biochem. Biophys. Res. Commun. 1992 182 : 1288 95.
12. Kuan SF, Byrd JC, Basbaum CB, Kim YS. Characterization of quantitative mucin variants from a human colon cancer cell line. Cancer Res. 1987 47 : 5715 24.
13. Ligtenberg MJL, Buijs F, Vos HL, Hilkens J. Suppression of cellular aggregation by high levels episialin. Cancer Res. 1992 52 : 2318 24.
14. Majuri ML, Mattila P, Renkonen R. Recombination E-selectin-protein mediates tumor cell adhesion via sialyl-Lea and sialyl-Lex. Biochem. Biophys. Res. Commun. 1992 182 : 1376 82.
15. Baldus SE, Zirbes TK, Engel S et al. Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas. Int. J. Cancer 1998 79 : 133 8.
16. Akyurek N, Akyol G, Dursun A, Yamac D, Gunel N. Expression of MUC1 and MUC2 mucins in gastric carcinomas: their relationship with clinicopathologic parameters and prognosis. Pathol. Res. Pract. 2002 198 : 665 74.
17. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 2001 92 : 1427 34.
18. Filipe MI, Linehan JM, Durrant LG et al. Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesion to gastric carcinoma. Eur. J. Cancer Prev. 1996 5 : 287 95.
19. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta. Pathol. Microbiol. Scand. 1965 64 : 31 49.
20. Chan AOO, Mc L, UK J, Hui WM, Lam SK. Molecular biology of gastric carcinoma: from laboratory to bedside. J. Gastroenterol. Hepatol. 1999 14 : 1150 60.
21. Borrmann R. Geschwulste des magens und duedenums. In : Henke F, Labarsch K, eds. Handbuch der Speziellen Patholigischen Anatomie und Histologie. Berlin : Springer, 1926 865.
22. Fenoglio-Preiser C, Carneiro F, Correa P et al. WHO histological classification of gastric tumours. In : Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Digestive System. Lyon : IARC, 2000 38.
23. Sobin LH, Wittekind C. TNM Classification of Malignant Tumors, 5th edn. New York : Wiley-Liss, 1997.
24. Remmele W, Schicketanz KH. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (QIC score) vs subjective grading (IRS). Pathol. Res. Pract. 1993 189 : 862 6.
25. SAS [Computer program].Version 8.1. Cary: SAS Institute Inc, 2002
26. Carrato C, Balague C, DeBolos C et al. Differential apomucin expression in normal and neoplastic gastrointestinal tissues. Gastroenterology 1994 107 : 160 72.
27. Dixon MF. Recent advances in gastritis. Curr. Diag. Pathol. 1994 1 : 80 89.
28. Lopez-Ferrer A, de Bolos C, Barranco C et al. Role of fucosyltransferase in the association between apomucin and Lewis antigensexpression in normal and malignant gastric epithelium. Gut 2002 47 : 349 56.
29. Filipe MI, Jass JR. Intestnal metaplasia subtypes and cancer risk. In : Filipe MI, Jass JR, eds. Gastric Carcinoma. London : Churchill Livingstone, 1986 87 115.
30. Filipe MI. Borderline lesions of the gastric epithelium: new indications of gastric risk and clinical implications. In : Fenoglio-Preiser CM, Wolff M, Rilke F, eds. Progress in Surgical Pathology. USA : Field and Wood, 1992 269 90.
31. Silva E, Teixeira A, Reis CA et al. Mucins as key molecules for the classification of intestinal metaplasia of the stomach. Virchows Arch. 2002 440 : 311 17.
32. Jass JR. Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J. Clin. Pathol. 1980 33 : 801 10.
33. Filipe MI, Potet F, Bgomoletz WV et al. Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut 1985 26 : 1319 26.
34. Kabashima A, Yao T, Sugimachi K, Tsuneyoshi M. Gastric intestinal phenotypic expression in the carcinomas and background mucosa of multiple early gastric carcinomas. Histopathology 2000 37 : 513 22.
35. Sasaki A, Kitadai Y, Ito M et al. Helicobacter pylori infection influences tumor growth of human gastric carcinomas. Scand. J. Gastroenterol. 2003 38 : 153 8.
36. Utsunomiya T, Yonezawa S, Sakamoto H et al. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin. Cancer Res. 1998 4 : 2605 14.
37. Pinto-de-Sousa J, David L, Reis CA, Gomes R, Silva L, Pimenta A. Mucins MUC1, MUC2, MUC5AC, and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma. Virchows Arch. 2002 440 : 304 10.
38. Wang RQ, Fang DC. Alteration of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features. J. Clin. Pathol. 2003 56 : 378 84.
39. Roessler K, Monig SP, Schneider PM et al. Co-expression of CDX2 and MUC2 in gastric carcinomas: correlations with clinico-pathologcal parameters and prognosis. World J. Gastroenterol. 2005 11 : 3182 8.
40. Mitsuuchi M, Hinoda Y, Itoh T et al. Expression of MUC2 gene in gastric regenerative, metaplastic, and neoplastic epithelia. J. Clin. Lab. Anal. 1999 13 : 259 65.
41. Gurbuz Y, Kahlke V, Kloppel G. How do gastric carcinoma classification systems relate to mucin expression pattern? An immunohistochemical analysis in a series of advanced gastric carcinomas. Virchows Arch. 2002 440 : 505 11.