Alterations of MUC1 and MUC3 expression in gastric carcinoma: Relevance to patient clinicopathological features

Journal of Clinical Pathology

Volumn 56, Issue 5, 2003, Pages 378-384

  Wang, R Q ^a   Fang, D C ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MUCIN; MUCIN 1; MUCIN 1 ANTIBODY; MUCIN 2; MUCIN 3; MUCIN 3 ANTIBODY; MUCIN 5; MUCIN 6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER INVASION; CARCINOGENESIS; CLINICAL ARTICLE; CLINICAL FEATURE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; METASTASIS; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SEROSA; STATISTICAL SIGNIFICANCE; STOMACH CARCINOMA; TUMOR VOLUME;

ADULT; AGED; CA-15-3 ANTIGEN; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; METAPLASIA; MIDDLE AGED; MUCINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM STAGING; PRECANCEROUS CONDITIONS; PROGNOSIS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0037994178     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.56.5.378     Document Type: Article

References (41)

1. Masaki Y, Oka M, Ogura Y, et al. Sialylated MUC1 mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma. Hepatogastroenterology 1999;46:2240-5.
2. Rahn J, Dabbagh L, Pasdar M, et al. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer 2001;91:1973-82
3. Hanisch F-G, Muller S. MUC1: the polymorphic appearance of a human mucin. Glycobiology 2000;10:439-49.
4. ctn. Biochem Biophys Res Commun 2001;281:440-3.
5. Gong J, Apostolopoulos V, Chen D, et al. Selection and characterization of MUC1-specific CD+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells. Immunology 2000;101:316-24.
6. Holmberg L, Sandmaier B. Theratope((R)) vaccine (STn-KLH). Expert Opin Biol Ther 2001;1:881-91.
7. Johnen H, Kulbe H, Pecher G. Long-term tumour growth suppression in mice immunized with naked DNA of the human tumor antigen mucin (MUC1). Cancer Immunol Immunother 2001;50:356-60.
8. Schmielau J, Nalesnik M, Finn O. Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients. Clin Cancer Res 2001;7:933s-9s.
9. Carraway KL, III, Rossi E, Komatsu M, et al. An intramembrane modulator of the erbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J Biol Chem 1998;274:5263-6.
10. Lee H, Lee H, Kim H, et al. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 2001;92:1427-34.
11. Chang S, Dohrman A, Basbaum C, et al. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 1994;107:28-36.
12. Copin M, Buisine M, Leteurtre E, et al. Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas. Hum Pathol 2001;32:274-81.
13. Nguyen P, Niehans G, Cherwitz D, et al. Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer. Tumour Biol 1996;17:176-92.
14. Ho S, Shekels LL, Toribara N, et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric carcinoma. Cancer Res 1995;55:2681-90.
15. Goseki N, Takizawa T, Koike M. Differences in the model of the extension of gastric cancer classified by histological type: new histological classification of gastric carcinoma. Gut 1992;33:606-12.
16. Xing P-X, Tjandra J, Slacker S, et al. Monoclonal antibodies reactive with mucin expressed in breast cancer. Immunol Cell Biol 1989;67:183-5.
17. Xing P-X, Apostolopoulos V, Pietersz G, et al. Anti-mucin monoclonal antibodies. Frontiers in Bioscience 2001;6:d1284-95.
18. Xing P-X, Prenzoska J, Layton G, et al. Second-generation monoclonal antibodies of intestinal MUC2 peptide reactive with colon cancer. J Natl Cancer Inst 1992;84:699-703.
19. Ma Y, Yuan M, Fei L. Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide. Zhonghua Zhong Liu Za Zhi 1996;18:419-21.
20. de Bolos C, Garrido M, Real F. MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 1995;109:723-34.
21. Moniaux N, Escande F, Porchet N, et al. Structural organization and classification of the human mucin genes. Front Biosci 2001;6:d1192-206.
22. Baldus S, Zirbes T, Engel S, et al. Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas. Int J Cancer 1998;79:133-8.
23. Utsunomiya T, Yonezawa S, Sakamoto H, et al. Expression of MUC1 and MUC2 mucins in gastric carcinoma: its relationship with the prognosis of the patients. Clin Cancer Res 1998;4:2605-14.
24. Baldus S, Zirbes T, Glossmann J, et al. Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric carcinoma. Oncology 2001;61:147-55.
25. Hudson M, Stamp G, Chaudhary K, et al. Human MUC1 mucin: a potent glandular morphogen. J Pathol 2001;194:373-83.
26. Nakamori S, Ota D, Cleary K, et al. MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 1994;106:353-61.
27. Terada T, Ohta T, Sasaki M, et al. Expression of MUC apomucins in normal pancreas and pancreatic lumours. J Pathol 1996;180:160-5.
28. Jass JR, Walsh MD. Altered mucin expression in the gaslrointestinal tract: a review. J Cell Mol Med 2001;5:327-51.
29. Kim Y, Gum J, Brockhausen I. Mucin glycoproteins in neoplasia. Glycoconj J 1996;13:693-707.
30. Gum JJ, Jr, Crawley S, Hicks J, et al. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun 2002;291:466-75.
31. Moniaux N, Nollet S, Porchet N, et al. Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J 1999;338:325-33.
32. Williams S, McGuckin M, Gotley D, et al. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 1999;59:4083-9.
33. Williams S, Wreschner D, Tran M, et al. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem 2001;276:18327-36.
34. Gum JJ, Jr, Ho J, Pratt W, et al. MUC3 human intestinal mucin: analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. J Biol Chem 1997;272:26678-86.
35. Khatri I, Forstner G, Forstner J. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Biochim Biophys Acta 1997;1326:7-11.
36. Shekels L, Hunninghake D, Tisdale A, et al. Cloning and characterization of mouse intestinal MUC3 mucin: 3′ sequence contains epidermal-growth-factor-like domains. Biochem J 1998;330:1301-8.
37. Carraway KL, Fregien N, Carraway KL, III, et al. Tumor sialomucin complexes as tumor antigens and modulators of cellular interactions and proliferation. J Cell Science 1992;103:299-307.
38. Nakajima M, Sawada H, Yamada Y, et al. The prognostic significance of amplification and overexpression of c-met and c-erbB-2 in human gastric carcinoma. Cancer 1999;85:1894-902.
39. Wu M, Shun C, Sheu J, et al. Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. J Gastroenterol Hepatol 1998;13:305-10.
40. Sakamoto H, Yonezawa S, Utsunomiya T, et al. Mucin antigen expression in gastric carcinoma of young and old adults. Hum Pathol 1997;28:1056-65.
41. Pinto-De-Sousa J, David L, Reis CA, et al. Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma. Virchows Arch 2002;440:304-10.