Pivotal Advance: Endogenous pathway to SIRS, sepsis, and related conditions

Journal of Leukocyte Biology

Volumn 82, Issue 2, 2007, Pages 282-285

  Tang, Amy H ^a,b   Brunn, Gregory J ^a   Cascalho, Marilia ^a,b   Platt, Jeffrey L ^a,b,c  

^a Mayo Clinic   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Heparan sulfate; Systemic inflammatory response syndrome; Toll like receptors

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

DENDRITIC CELL; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE ACTIVATION;

ANIMALS; HEPARITIN SULFATE; HUMANS; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TOLL-LIKE RECEPTORS;

EID: 34547763337     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1206752     Document Type: Review

References (35)

1. Ehrlich, P., Morgenroth, J. (1901) On hæmolysins. Fifth communication. In The Collected Papers of Paul Ehrlich, vol. 2 (F. Himmelweit, ed.), London, UK, Pergamon, 246-255.
2. Kahler, C. M., Stephens, D. S. (1998) Genetic basis for biosynthesis, structure, and function of meningococcal lipooligosaccharide (endotoxin). Crit. Rev. Microbiol. 24, 281-334.
3. Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., Aderem, A. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. USA 97, 13766-13771.
4. Medzhitov, R., Janeway Jr., C. A. (2002) Decoding the patterns of self and nonself by the innate immune system. Science 296, 298-300.
5. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., Beutler, B. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088.
6. Akira, S., Takeda, K. (2004) Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499-511.
7. Nowotny, N. (1971) Chemical and biological heterogeneity of endotoxins. In Microbial Toxins, vol. IV (G. Weinbaum, S. Kadis, S. J. Ajl, eds.), New York, NY, USA, Academic, 309-329.
8. Cross, A. S., Sadoff, J. C., Kelly, N., Bernton, E., Gemski, P. (1989) Pretreatment with recombinant murine tumor necrosis factor α/cachectin and murine interleukin 1 α protects mice from lethal bacterial infection. J. Exp. Med. 169, 2021-2027.
9. Beutler, B. (2001) Sepsis begins at the interface of pathogen and host. Biochem. Soc. Trans. 29, 853-859.
10. Dunn, D. L. (2000) Prevention and treatment of multiple organ dysfunction syndrome: lessons learned and future prospects. Surg. Infect. (Larchmt) 1, 227-237.
11. Zhai, Y., Shen, X. D., O'Connell, R., Gao, F., Lassman, C., Busuttil, R. W., Cheng, G., Kupiec-Weglinski, J. W. (2004) Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J. Immunol. 173, 7115-7119.
12. Kiechl, S., Lorenz, E., Reindl, M., Wiedermann, C. J., Oberhollenzer, F., Bonora, E., Willeit, J., Schwartz, D. A. (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347, 185-192.
13. Johnson, G. B., Riggs, B. L., Platt, J. L. (2004) A genetic basis for the "Adonis" phenotype of low adiposity and strong bones. FASEB J. 18, 1282-1284.
14. Ihrcke, N. S., Wrenshall, L. E., Lindman, B. J., Platt, J. L. (1993) Role of heparan sulfate in immune system-blood vessel interactions. Immunol. Today 14, 500-505.
15. Saadi, S., Wrenshall, L. E., Platt, J. L. (2002) Regional manifestations and control of the immune system. FASEB J. 16, 849-856.
16. Platt, J. L., Vercellotti, G. M., Lindman, B. J., Oegema Jr., T. R., Bach, F. H., Dalmasso, A. P. (1990) Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J. Exp. Med. 171, 1363-1368.
17. Key, N. S., Platt, J. L., Vercellotti, G. M. (1992) Vascular endothelial cell proteoglycans are susceptible to cleavage by neutrophils. Arterioscler. Thromb. 12, 836-842.
18. Geller, R. L., Ihrcke, N. S., Platt, J. L. (1994) Release of endothelial cell-associated heparan sulfate proteoglycan by activated T cells. Transplantation 57, 770-774.
19. Saadi, S., Takahashi, T., Holzknecht, R. A., Platt, J. L. (2004) Pathways to acute humoral rejection. Am. J. Pathol. 164, 1073-1080.
20. Wrenshall, L. E., Cerra, F. B., Carlson, A., Bach, F. H., Platt, J. L. (1991) Regulation of murine splenocyte responses by heparan sulfate. J. Immunol. 147, 455-459.
21. Wrenshall, L. E., Cerra, F. B., Singh, R. K., Platt, J. L. (1995) Heparan sulfate initiates signals in murine macrophages leading to divergent biological outcomes. J. Immunol. 154, 871-880.
22. Kodaira, Y., Nair, S. K., Wrenshall, L. E., Gilboa, E., Platt, J. L. (2000) Phenotypic and functional maturation of dendritic cells modulated by heparan sulfate. J. Immunol. 165, 1599-1604.
23. Medzhitov, R., Preston-Hurlburt, P., Janeway Jr., C. A. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397.
24. Johnson, G. B., Brunn, G. J., Kodaira, Y., Platt, J. L. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168, 5233-5239.
25. Johnson, G. B., Brunn, G. J., Tang, A. H., Platt, J. L. (2003) Evolutionary clues to the functions of the Toll-like family as surveillance receptors. Trends Immunol. 24, 19-24.
26. Johnson, G. B., Brunn, G. J., Platt, J. L. (2003) Activation of mammalian Toll-like receptors by endogenous agonists. Crit. Rev. Immunol. 23, 15-44.
27. Johnson, G. B., Brunn, G. J., Platt, J. L. (2004) An endogenous pathway to systemic inflammatory response syndrome (SIRS)-like responses through Toll-like receptor 4. J. Immunol. 172, 20 -24 (Cutting Edge).
28. Galanos, C., Freudenberg, M. A., Reutter, W. (1979) Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76, 5939-5943.
29. Brunn, G. J., Bungum, M. K., Johnson, G. B., Platt, J. L. (2005) Conditional signaling by Toll-like receptor 4. FASEB J. 19, 872-874.
30. Werner, M., Topp, R., Wimmer, K., Richter, K., Bischof, W., Wjst, M., Heinrich, J. (2003) TLR4 gene variants modify endotoxin effects on asthma. J. Allergy Clin. Immunol. 112, 323-330.
31. Ihrcke, N. S., Platt, J. L. (1996) Shedding of heparan sulfate proteoglycan by stimulated endothelial cells: evidence for proteolysis of cell surface molecules. J. Cell. Physiol. 168, 625-637.
32. Ihrcke, N. S., Parker, W., Reissner, K. J., Platt, J. L. (1998) Regulation of platelet heparanase during inflammation: role of pH and proteinases. J. Cell. Physiol. 175, 255-267.
33. Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., Flier, J. S. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025.
34. Song, M. J., Kim, K. H., Yoon, J. M., Kim, J. B. (2006) Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem. Biophys. Res. Commun. 346, 739-745.
35. Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., Simon, J. C. (2002) Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4. J. Exp. Med. 195, 99-111.