Understanding diet-gene interactions: Lessons from studying nutrigenomics and cardiovascular disease

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 622, Issue 1-2, 2007, Pages 7-13

  Low, Yen Ling ^a   Tai, E Shyong ^b  

^a GENOME INSTITUTE OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Cardiovascular disease; Diet; Genetics; Perilipin; Peroxisome proliferator activated receptor alpha

Indexed keywords

FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

CARDIOVASCULAR DISEASE; CHRONIC DISEASE; DIET; ENVIRONMENTAL FACTOR; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; NUTRIGENOMICS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

CARDIOVASCULAR DISEASES; DIET; GENES; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HUMANS; NUTRITION PHYSIOLOGY; POLYMORPHISM, GENETIC;

EID: 34547693175     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.01.015     Document Type: Review

References (45)

1. Dwyer T., Emmanuel S.C., Janus E.D., Wu Z., Hynes K.L., and Zhang C. The emergence of coronary heart disease in populations of Chinese descent. Atherosclerosis 167 (2003) 303-310
2. Khoo K.L., Tan H., Liew Y.M., Deslypere J.P., and Janus E. Lipids and coronary heart disease in Asia. Atherosclerosis 169 (2003) 1-10
3. Hughes K. Trends in mortality from ischaemic heart disease in Singapore, 1959-1983. Int. J. Epidemiol. 15 (1986) 44-50
4. Mak K.H., Chia K.S., Kark J.D., Chua T., Tan C., Foong B.H., Lim Y.L., and Chew S.K. Ethnic differences in acute myocardial infarction in Singapore. Eur. Heart J. 24 (2003) 151-160
5. Wienke A., Holm N.V., Skytthe A., and Yashin A.I. The heritability of mortality due to heart diseases: a correlated frailty model applied to Danish twins. Twin Res. 4 (2001) 266-274
6. Zdravkovic S., Wienke A., Pedersen N.L., Marenberg M.E., Yashin A.I., and De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J. Intern. Med. 252 (2002) 247-254
7. Evans A., Van Baal G.C., McCarron P., DeLange M., Soerensen T.I., De Geus E.J., Kyvik K., Pedersen N.L., Spector T.D., Andrew T., Patterson C., Whitfield J.B., Zhu G., Martin N.G., Kaprio J., and Boomsma D.I. The genetics of coronary heart disease: the contribution of twin studies. Twin Res. 6 (2003) 432-441
8. Heller D.A., de Faire U., Pedersen N.L., Dahlen G., and McClearn G.E. Genetic and environmental influences on serum lipid levels in twins. N. Engl. J. Med. 328 (1993) 1150-1156
9. Yusuf S., Hawken S., Ounpuu S., Dans T., Avezum A., Lanas F., McQueen M., Budaj A., Pais P., Varigos J., and Lisheng L. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364 (2004) 937-952
10. Law M.R., Wald N.J., and Rudnicka A.R. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 326 (2003) 1423
11. Robins S.J., and Bloomfield H.E. Fibric acid derivatives in cardiovascular disease prevention: results from the large clinical trials. Curr. Opin. Lipidol. 17 (2006) 431-439
12. Torra I.P., Chinetti G., Duval C., Fruchart J.C., and Staels B. Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr. Opin. Lipidol. 12 (2001) 245-254
13. Lacquemant C., Lepretre F., Pineda Torra I., Manraj M., Charpentier G., Ruiz J., Staels B., and Froguel P. Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. Diabetes Metab. 26 (2000) 393-401
14. Tai E.S., Demissie S., Cupples L.A., Corella D., Wilson P.W., Schaefer E.J., and Ordovas J.M. Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 805-810
15. Vohl M.C., Lepage P., Gaudet D., Brewer C.G., Betard C., Perron P., Houde G., Cellier C., Faith J.M., Despres J.P., Morgan K., and Hudson T.J. Molecular scanning of the human PPARa gene: association of the L162V mutation with hyperapobetalipoproteinemia. J. Lipid. Res. 41 (2000) 945-952
16. Sapone A., Peters J.M., Sakai S., Tomita S., Papiha S.S., Dai R., Friedman F.K., and Gonzalez F.J. The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants. Pharmacogenetics 10 (2000) 321-333
17. Jump D.B. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr. Opin. Lipidol. 13 (2002) 155-164
18. Tai E.S., Corella D., Demissie S., Cupples L.A., Coltell O., Schaefer E.J., Tucker K.L., and Ordovas J.M. Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study. J. Nutr. 135 (2005) 397-403
19. Chan E., Tan C.S., Deurenberg-Yap M., Chia K.S., Chew S.K., and Tai E.S. The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women. Atherosclerosis 187 (2006) 309-315
20. Haffner S.M. Epidemiology of insulin resistance and its relation to coronary artery disease. Am. J. Cardiol. 84 (1999) 11J-14J
21. Greenberg A.S., Egan J.J., Wek S.A., Garty N.B., Blanchette-Mackie E.J., and Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266 (1991) 11,341-11,346
22. Greenberg A.S., Egan J.J., Wek S.A., Moos Jr. M.C., Londos C., and Kimmel A.R. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc. Natl. Acad. Sci. USA 90 (1993) 12,035-12,039
23. Londos C., Brasaemle D.L., Gruia-Gray J., Servetnick D.A., Schultz C.J., Levin D.M., and Kimmel A.R. Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells. Biochem. Soc. Trans. 23 (1995) 611-615
24. Tansey J.T., Huml A.M., Vogt R., Davis K.E., Jones J.M., Fraser K.A., Brasaemle D.L., Kimmel A.R., and Londos C. Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J. Biol. Chem. 278 (2003) 8401-8406
25. Tansey J.T., Sztalryd C., Gruia-Gray J., Roush D.L., Zee J.V., Gavrilova O., Reitman M.L., Deng C.X., Li C., Kimmel A.R., and Londos C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA 98 (2001) 6494-6499
26. Souza S.C., Muliro K.V., Liscum L., Lien P., Yamamoto M.T., Schaffer J.E., Dallal G.E., Wang X., Kraemer F.B., Obin M., and Greenberg A.S. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J. Biol. Chem. 277 (2002) 8267-8272
27. Souza S.C., de Vargas L.M., Yamamoto M.T., Lien P., Franciosa M.D., Moss L.G., and Greenberg A.S. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 273 (1998) 24,665-24,669
28. Brasaemle D.L., Rubin B., Harten I.A., Gruia-Gray J., Kimmel A.R., and Londos C. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 275 (2000) 38,486-38,493
29. Mottagui-Tabar S., Ryden M., Lofgren P., Faulds G., Hoffstedt J., Brookes A.J., Andersson I., and Arner P. Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia 46 (2003) 789-797
30. Kern P.A., Di Gregorio G., Lu T., Rassouli N., and Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J. Clin. Endocrinol. Metab. 89 (2004) 1352-1358
31. Martinez-Botas J., Anderson J.B., Tessier D., Lapillonne A., Chang B.H., Quast M.J., Gorenstein D., Chen K.H., and Chan L. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat. Genet. 26 (2000) 474-479
32. Qi L., Corella D., Sorli J.V., Portoles O., Shen H., Coltell O., Godoy D., Greenberg A.S., and Ordovas J.M. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin. Genet. 66 (2004) 299-310
33. Qi L., Tai E.S., Tan C.E., Shen H., Chew S.K., Greenberg A.S., Corella D., and Ordovas J.M. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J. Mol. Med. 83 (2005) 448-456
34. Corella D., Qi L., Tai E.S., Deurenberg-Yap M., Tan C.E., Chew S.K., and Ordovas J.M. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 29 (2006) 1313-1319
35. Holtzman N.A. Genetic variation in nutritional requirements and susceptibility to disease: policy implications. Am. J. Clin. Nutr. 48 (1988) 1510-1516
36. Khoury M.J., Davis R., Gwinn M., Lindegren M.L., and Yoon P. Do we need genomic research for the prevention of common diseases with environmental causes?. Am. J. Epidemiol. 161 (2005) 799-805
37. De Caterina R., Zampolli A., Del Turco S., Madonna R., and Massaro M. Nutritional mechanisms that influence cardiovascular disease. Am. J. Clin. Nutr. 83 (2006) 421S-426S
38. Chahoud G., Aude Y.W., and Mehta J.L. Dietary recommendations in the prevention and treatment of coronary heart disease: do we have the ideal diet yet?. Am. J. Cardiol. 94 (2004) 1260-1267
39. Howard B.V., Van Horn L., Hsia J., Manson J.E., Stefanick M.L., Wassertheil-Smoller S., Kuller L.H., LaCroix A.Z., Langer R.D., Lasser N.L., Lewis C.E., Limacher M.C., Margolis K.L., Mysiw W.J., Ockene J.K., Parker L.M., Perri M.G., Phillips L., Prentice R.L., Robbins J., Rossouw J.E., Sarto G.E., Schatz I.J., Snetselaar L.G., Stevens V.J., Tinker L.F., Trevisan M., Vitolins M.Z., Anderson G.L., Assaf A.R., Bassford T., Beresford S.A., Black H.R., Brunner R.L., Brzyski R.G., Caan B., Chlebowski R.T., Gass M., Granek I., Greenland P., Hays J., Heber D., Heiss G., Hendrix S.L., Hubbell F.A., Johnson K.C., and Kotchen J.M. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295 (2006) 655-666
40. Couzin J. Women's health. Study yields murky signals on low-fat diets and disease. Science 311 (2006) 755
41. Stein K. After the media feeding frenzy: whither the Women's Health Initiative Dietary Modification Trial?. J. Am. Diet. Assoc. 106 (2006) 794-800
42. Cox C., Mann J., Sutherland W., and Ball M. Individual variation in plasma cholesterol response to dietary saturated fat. BMJ 311 (1995) 1260-1264
43. Lichtenstein A.H., Ausman L.M., Jalbert S.M., and Schaefer E.J. Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N. Engl. J. Med. 340 (1999) 1933-1940
44. Florez J.C., Jablonski K.A., Bayley N., Pollin T.I., de Bakker P.I., Shuldiner A.R., Knowler W.C., Nathan D.M., and Altshuler D. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N. Engl. J. Med. 355 (2006) 241-250
45. Manolio T.A., Bailey-Wilson J.E., and Collins F.S. Genes, environment and the value of prospective cohort studies. Nat. Rev. Genet. 7 (2006) 812-820