Mutation screening of the PPARα gene in type 2 diabetes associated with coronary heart disease

Diabetes and Metabolism

Volumn 26, Issue 5, 2000, Pages 393-401

  Lacquemant, C ^a   Lepretre, F ^a   Pineda Torra, I ^a   Manraj, M ^a   Charpentier, G ^a   Ruiz, J ^a   Staels, B ^a   Froguel, P H ^a  

^a INSTITUT DE BIOLOGIE DE LILLE   (France)

Author keywords

CHD; Gene; Plasma lipids; PPAR ; Type 2 diabetes

Indexed keywords

ADULT; AGED; ARTICLE; ATHEROGENESIS; CORONARY RISK; GENE MUTATION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; AMINO ACID SUBSTITUTION; CAUCASIAN; CORONARY ARTERY DISEASE; DIABETIC ANGIOPATHY; ETHNOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; GENETICS; INDIA; MALE; MAURITIUS; MIDDLE AGED; MUTATION; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

CELL RECEPTOR; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DNA-BINDING PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC SCREENING; HUMANS; INDIA; MALE; MAURITIUS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREVALENCE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 0033625985     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Banting lecture. Role of insulin resistance in human disease
2. The insulin resistance syndrome
3. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial
4. Familial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathy
5. Peroxisome proliferator-activated receptors, orphans with ligands and functions
6. Hypolipidemic drags, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors a and d
7. Mechanism of action of fibrates on lipid and lipoprotein metabolism
8. Studies on the mechanism of fibrate-inhibited expression of plasminogen actlvator-1 in cultured hepatoeytes from cymologous monkey
9. The effects of fibrates on lipoprotein and hemostatic coronary risk factors
10. The PPARa-leukotriene B4 pathway to inflammation control
11. Anti-atheromatous effects of fenofibrate, a hypolipidemic drug I: Anti-atheromatous effects are independent of its hypolipidemic effect in cholesterol-fed rabbits
12. Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients
13. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
14. Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging
15. The pathogenesis of atherosclerosis: A perspective for the 1990s
16. Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia lib
17. PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
18. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
19. Rising prevalence of NIDDM in an urban population in India
20. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians
21. Automated fluorescence-based screening for mutation by SSCP: Use of universal M13 dye primers for labeling and detection
22. Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil indians from Pondichery
23. Amino acid residues in both the DNA-binding and ligand-binding domains influence transcriptional activity of the human peroxisome proliferator-activated receptor alpha
24. Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM
25. Familial lipoprotein disorders in patients with premature coronary artery disease
26. Insulin resistance: A multifaced syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
27. Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19
28. Variation in the PPARa gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects