The SOCS-1 gene methylation in chronic myeloid leukemia patients

American Journal of Hematology

Volumn 82, Issue 8, 2007, Pages 729-730

  Hatirnaz, Ozden ^a   Ure, Umit ^a   Ar, Cem ^a   Akyerli, Cemaliye ^b   Soysal, Teoman ^a   Ferhanoǧlu, Burhan ^a   Özçelik, Tayfun ^c   Ozbek, Ugur ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c BILKENT UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; JANUS KINASE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1;

ARTICLE; CANCER GROWTH; CANCER PATIENT; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA METHYLATION; EXON; FEMALE; GENE; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SOCS 1 GENE;

ADULT; DNA METHYLATION; EXONS; FEMALE; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 34547687395     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.20886     Document Type: Article

References (10)

1. Krebs DL, Hilton DJ. SOCS: Physiological suppressors of cytokine signaling. J Cell Sci 2000;113:2813-2819.
2. Krebs DL, Hilton DJ. SOCS proteins: Negative regulators of cytokine signaling. Stem Cells 2001;19:378-387.
3. Frank DA, Varticovski L. BCR/abl leads to the constitutive activation of proteins, and shares an epitope with tyrosine phosphorylated stats. Leukemia 1996;10:1724-1730.
4. Nieborowska-Skorska M, Wasik MA, Slupianek A, et al. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med 1999;189:1229-1242.
5. Chim CS, Fung TK, Cheung WC, Liang R, Kwong YL. SOCS1 and SHP1 hypermethylation in multiple myeloma: Implications for epigenetic activation of the Jak/STAT pathway. Blood 2004;103:4630-4635.
6. Nagai H, Naka T, Terada Y, et al. Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J Hum Genet 2003;48:65-69.
7. Yoshikawa H, Matsubara K, Qian GS, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001;28:29-35.
8. Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 1992;89:1827-1831.
9. Johan MF, Bowen DT, Frew ME, Goodeve AC, Reilly JT. Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol. 2005;129:60-5.
10. Liu TC, Lin SF, Chang JG, et al. Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. Br J Haematol 2003;123:654-661.