Different roles of pummelo furanocoumarin and cytochrome P450 3A5*3 polymorphism in the fate and action of felodipine

Current Drug Metabolism

Volumn 8, Issue 6, 2007, Pages 623-630

  Guo, Lian Qing ^a   Chen, Qiao Yun ^a   Wang, Xuan ^b   Liu, Yu Xiu ^a   Chu, Xiao Man ^a   Cao, Xiao Mei ^a   Li, Jin Heng ^a   Yamazoe, Yasushi ^c  

^a NANJING UNIVERSITY   (China)

^b The 81st Hospital of PLA   (China)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Blood pressure; Cytochrome P450 3A5*3; Felodipine; Furanocoumarin; Heart rate; Pummelo

Indexed keywords

6',7' DIHYDROXYBERGAMOTTIN; BERGAMOTTIN; BERGAMOTTIN 6',7' EPOXIDE; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLIZING ENZYME; FELODIPINE; FUROCOUMARIN; FUROCOUMARIN DERIVATIVE; PARADISIN A; PARADISIN B; PARADISIN C; PLANT EXTRACT; PUMMELO EXTRACT; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; AMINO ACID SEQUENCE; AREA UNDER THE CURVE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; ENZYME INHIBITION; FOOD ANALYSIS; FOOD DRUG INTERACTION; GENETIC POLYMORPHISM; GRAPEFRUIT JUICE; HEMODYNAMICS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; NUCLEOTIDE SEQUENCE; PHYTOCHEMISTRY; PUMMELO; REVIEW; SINGLE DRUG DOSE;

ADULT; BEVERAGES; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CITRUS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; FELODIPINE; FOOD-DRUG INTERACTIONS; GENOTYPE; HEART RATE; HUMANS; HYDROXYLATION; MALE; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PSORALENS; TESTOSTERONE;

EID: 34547683240     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007781368917     Document Type: Review

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