메뉴 건너뛰기




Volumn 100, Issue 3, 2007, Pages 685-690

Increased Akt and phosphorylated Akt expression are associated with malignant biological features of prostate cancer in Japanese men

Author keywords

Akt; Androgen receptor; Phosphorylated Akt; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; KI 67 ANTIGEN; PROTEIN KINASE B;

EID: 34547645592     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2007.07014.x     Document Type: Article
Times cited : (30)

References (32)
  • 2
    • 0028086057 scopus 로고
    • Management of cancer of the prostate
    • Catalona WJ. Management of cancer of the prostate. N Engl J Med 1994 331 : 996 1004
    • (1994) N Engl J Med , vol.331 , pp. 996-1004
    • Catalona, W.J.1
  • 3
    • 0034612780 scopus 로고    scopus 로고
    • Apoptosis: Translating theory to therapy for prostate cancer
    • Isaacs JT. Apoptosis: translating theory to therapy for prostate cancer. J Natl Cancer Inst 2000 92 : 1367 9
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1367-9
    • Isaacs, J.T.1
  • 4
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997 275 : 1943 7
    • (1997) Science , vol.275 , pp. 1943-7
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 5
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997 15 : 356 62
    • (1997) Nat Genet , vol.15 , pp. 356-62
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 6
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998 95 : 29 39
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    De La Pompa, J.L.3
  • 7
    • 0035914388 scopus 로고    scopus 로고
    • Akt-1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt-1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001 276 : 38349 52
    • (2001) J Biol Chem , vol.276 , pp. 38349-52
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 8
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt-2 (PKBβ)
    • Cho H, Mu J, Kim JK et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt-2 (PKBβ). Science 2001 292 : 1728 31
    • (2001) Science , vol.292 , pp. 1728-31
    • Cho, H.1    Mu, J.2    Kim, J.K.3
  • 9
    • 20044382806 scopus 로고    scopus 로고
    • Role for Akt-3/protein kinase Bγ in attainment of normal brain size
    • Easton RM, Cho H, Roovers K et al. Role for Akt-3/protein kinase Bγ in attainment of normal brain size. Mol Cell Biol 2005 25 : 1869 78
    • (2005) Mol Cell Biol , vol.25 , pp. 1869-78
    • Easton, R.M.1    Cho, H.2    Roovers, K.3
  • 10
    • 0038271762 scopus 로고    scopus 로고
    • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
    • Majumder PK, Yeh JJ, George DJ et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci USA 2003 100 : 7841 6
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7841-6
    • Majumder, P.K.1    Yeh, J.J.2    George, D.J.3
  • 11
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
    • Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 1999 59 : 2891 7
    • (1999) Cancer Res , vol.59 , pp. 2891-7
    • Lin, J.1    Adam, R.M.2    Santiestevan, E.3    Freeman, M.R.4
  • 12
    • 0034637524 scopus 로고    scopus 로고
    • Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
    • Graff JR, Konicek BW, McNulty AM et al. Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J Biol Chem 2000 275 : 24500 5
    • (2000) J Biol Chem , vol.275 , pp. 24500-5
    • Graff, J.R.1    Konicek, B.W.2    McNulty, A.M.3
  • 13
    • 0037106457 scopus 로고    scopus 로고
    • Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells
    • Manin M, Baron S, Goossens K et al. Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. Biochem J 2002 366 : 729 36
    • (2002) Biochem J , vol.366 , pp. 729-36
    • Manin, M.1    Baron, S.2    Goossens, K.3
  • 14
    • 0142117190 scopus 로고    scopus 로고
    • Increase of AKT/PKB expression correlates with Gleason pattern in human prostate cancer
    • Liao Y, Grobholz R, Abel U et al. Increase of AKT/PKB expression correlates with Gleason pattern in human prostate cancer. Int J Cancer 2003 107 : 676 80
    • (2003) Int J Cancer , vol.107 , pp. 676-80
    • Liao, Y.1    Grobholz, R.2    Abel, U.3
  • 15
    • 0036554734 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer
    • Malik SN, Brattain M, Ghosh PM et al. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Clin Cancer Res 2002 8 : 1168 71
    • (2002) Clin Cancer Res , vol.8 , pp. 1168-71
    • Malik, S.N.1    Brattain, M.2    Ghosh, P.M.3
  • 16
    • 3442891477 scopus 로고    scopus 로고
    • Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer
    • Kreisberg JI, Malik SN, Prihoda TJ et al. Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer. Cancer Res 2004 64 : 5232 6
    • (2004) Cancer Res , vol.64 , pp. 5232-6
    • Kreisberg, J.I.1    Malik, S.N.2    Prihoda, T.J.3
  • 17
    • 5144228549 scopus 로고    scopus 로고
    • High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    • Ayala G, Thompson T, Yang G et al. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 2004 10 : 6572 8
    • (2004) Clin Cancer Res , vol.10 , pp. 6572-8
    • Ayala, G.1    Thompson, T.2    Yang, G.3
  • 18
    • 33745093814 scopus 로고    scopus 로고
    • Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients
    • Le Page C, Koumakpayi IH, Alam-Fahmy M, Mes-Masson AM, Saad F. Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients. Br J Cancer 2006 94 : 1906 12
    • (2006) Br J Cancer , vol.94 , pp. 1906-12
    • Le Page, C.1    Koumakpayi, I.H.2    Alam-Fahmy, M.3    Mes-Masson, A.M.4    Saad, F.5
  • 19
    • 0031815139 scopus 로고    scopus 로고
    • Mutations of ras genes are relatively frequent in Japanese prostate cancers: Pointing to genetic differences between populations
    • Shiraishi T, Muneyuki T, Fukutome K et al. Mutations of ras genes are relatively frequent in Japanese prostate cancers: pointing to genetic differences between populations. Anticancer Res 1998 18 : 2789 92
    • (1998) Anticancer Res , vol.18 , pp. 2789-92
    • Shiraishi, T.1    Muneyuki, T.2    Fukutome, K.3
  • 20
    • 16344368667 scopus 로고    scopus 로고
    • Changing demography of prostate cancer in Asia
    • Sim HG, Cheng CW. Changing demography of prostate cancer in Asia. Eur J Cancer 2005 41 : 834 45
    • (2005) Eur J Cancer , vol.41 , pp. 834-45
    • Sim, H.G.1    Cheng, C.W.2
  • 21
    • 23744485107 scopus 로고    scopus 로고
    • Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population
    • Inoue T, Segawa T, Shiraishi T et al. Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population. Urology 2005 66 : 332 7
    • (2005) Urology , vol.66 , pp. 332-7
    • Inoue, T.1    Segawa, T.2    Shiraishi, T.3
  • 22
    • 1942435568 scopus 로고    scopus 로고
    • Expression of PTEN in malignant and non-malignant human prostate tissues: Comparison with p27 protein expression
    • Fenic I, Franke F, Failng K, Steger K, Woenckhaus J. Expression of PTEN in malignant and non-malignant human prostate tissues: comparison with p27 protein expression. J Pathol 2004 203 : 559 66
    • (2004) J Pathol , vol.203 , pp. 559-66
    • Fenic, I.1    Franke, F.2    Failng, K.3    Steger, K.4    Woenckhaus, J.5
  • 23
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999 253 : 210 29
    • (1999) Exp Cell Res , vol.253 , pp. 210-29
    • Kandel, E.S.1    Hay, N.2
  • 24
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000 404 : 782 7
    • (2000) Nature , vol.404 , pp. 782-7
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 25
    • 16444377912 scopus 로고    scopus 로고
    • Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation
    • Ghosh PM, Malik SN, Bedolla RG et al. Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation. Endocr Relat Cancer 2005 12 : 119 34
    • (2005) Endocr Relat Cancer , vol.12 , pp. 119-34
    • Ghosh, P.M.1    Malik, S.N.2    Bedolla, R.G.3
  • 26
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 1998 12 : 502 13
    • (1998) Genes Dev , vol.12 , pp. 502-13
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 27
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999 344 : 427 31
    • (1999) Biochem J , vol.344 , pp. 427-31
    • Nave, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 28
    • 33646739524 scopus 로고    scopus 로고
    • Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor
    • Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci USA 2006 103 : 7789 94
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7789-94
    • Xin, L.1    Teitell, M.A.2    Lawson, D.A.3    Kwon, A.4    Mellinghoff, I.K.5    Witte, O.N.6
  • 29
    • 3042760475 scopus 로고    scopus 로고
    • High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy
    • Li R, Wheeler T, Dai H, Frolov A, Thompson T, Ayala G. High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy. Am J Surg Pathol 2004 28 : 928 34
    • (2004) Am J Surg Pathol , vol.28 , pp. 928-34
    • Li, R.1    Wheeler, T.2    Dai, H.3    Frolov, A.4    Thompson, T.5    Ayala, G.6
  • 30
    • 33745263236 scopus 로고    scopus 로고
    • Intensity of androgen and epidermal growth factor receptor immunoreactivity in sample of radical prostatectomy as prognostic indicator: Correlation with clinical data of long-term observations
    • Schafer W, Funke PJ, Kunde D, Rausch U, Wennemuth G, Stutzer H. Intensity of androgen and epidermal growth factor receptor immunoreactivity in sample of radical prostatectomy as prognostic indicator: correlation with clinical data of long-term observations. J Urol 2006 176 : 532 7
    • (2006) J Urol , vol.176 , pp. 532-7
    • Schafer, W.1    Funke, P.J.2    Kunde, D.3    Rausch, U.4    Wennemuth, G.5    Stutzer, H.6
  • 31
    • 0021182777 scopus 로고
    • Antagonistic effect of androgen on prostatic cell death
    • Isaacs JT. Antagonistic effect of androgen on prostatic cell death. Prostate 1984 5 : 545 57
    • (1984) Prostate , vol.5 , pp. 545-57
    • Isaacs, J.T.1
  • 32
    • 16544391770 scopus 로고    scopus 로고
    • Reference ranges of serum total and free testosterone in Japanese male adults
    • Iwamoto T, Yanase T, Koh E et al. [Reference ranges of serum total and free testosterone in Japanese male adults]. Nippon Hinyokika Gakkai Zasshi 2004 95 : 751 60
    • (2004) Nippon Hinyokika Gakkai Zasshi , vol.95 , pp. 751-60
    • Iwamoto, T.1    Yanase, T.2    Koh, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.