Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 505, Issue 1-2, 2002, Pages 75-81

  Dinçer, Yildiz ^a   Akçay, Tülay ^a   Alademir, Zeynep ^a   Ilkova, Hasan ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Comet assay; Diabetes; DNA base oxidation; DNA damage; Glutathione

Indexed keywords

DNA; DNA GLYCOSYLTRANSFERASE; GLUTATHIONE; GUANINE; HEMOGLOBIN;

ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SEX DIFFERENCE;

COMET ASSAY; DIABETES MELLITUS, TYPE 2; DNA; DNA DAMAGE; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; FEMALE; GLUTATHIONE; GUANINE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; N-GLYCOSYL HYDROLASES; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 0037194640     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00143-4     Document Type: Article

References (35)

1. Enhanced serum levels of thiobarbituric acid-reactive substances in diabetes mellitus
2. Oxidative protein damage in plasma of type 2 diabetic patients
3. Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage
4. Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase
5. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions
6. The susceptibility of red blood cells to autoxidation in type 2 diabetic patients with angiopathy
7. Oxidative damage to DNA in diabetes mellitus
8. Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA
9. Comet assay to detect nitric oxide-dependent DNA damage in mammalian cells
10. Chromosomal aberrations and alkaline comet assay in families with habitual abortion
11. DNA damage in diabetes: Correlation with a clinical marker
12. Increased single strand breaks in DNA of lymphocytes from diabetic subjects
13. Detection of oxidative damage to DNA in diabetes mellitus by comet assay
14. Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects
15. Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation
16. Determination of glycosylated haemoglobins
17. A simple technique for quantification of low levels of DNA damage in individual cells
18. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
19. Improved method for determination of blood glutathione
20. Determination of hemoglobin and its derivatives
21. Ataxia telangiectasia: An anomaly in DNA replication after irradiation
22. Detection of free radicals and other reactive species: Trapping and finger printing
23. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells
24. Blood and leukocyte glutathione and glutathione S-transferase: Relationship to cholesterolemia in healthy volunteers
25. Oxidative DNA damage measured in human lymphocytes: Large differences between sexes and between countries and correlation with heart disease mortality rates
26. Homogenous Escherichia coli FPG protein
27. Glutathione metabolic enzyme activities in diabetic platelets as a function of glycemic control
28. Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM
29. Glycation and oxidation: A role in the pathogenesis of atherosclerosis
30. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents
31. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes
32. The role of 8-hydroxyguanine in carcinogenesis
33. Diabetes mellitus and cancer risk: A multisite case control study
34. Diabetes mellitus as a risk factor for pancreatic cancer: A meta-analysis
35. Diabetes mellitus