Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: In vivo and in vitro studies

World Journal of Gastroenterology

Volumn 13, Issue 27, 2007, Pages 3677-3683

  Federico, Alessandro ^a   Filippelli, A ^a   Falciani, M ^a   Tuccillo, C ^a   Tiso, A ^a   Floreani, A ^b   Naccarato, R ^b   Rossi, F ^a   Del Vecchio Blanco, C ^a   Loguercio, C ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Anti aggregant; Function of platelets; Hepatitis C; Liver disease; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; ADENOSINE DIPHOSPHATE; COLLAGEN; CYSTEINE; GLUTATHIONE; INTERLEUKIN 6; MALONALDEHYDE; NITRITE; S NITROSOGLUTATHIONE; S NITROSOTHIOL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CHRONIC HEPATITIS; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; HEPATITIS C; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PROTEIN DETERMINATION; STATISTICAL SIGNIFICANCE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION;

EID: 34547619042     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i27.3677     Document Type: Article

References (50)

1. Espanol I, Gallego A, Enriquez J, Rabella N, Lerma E, Hernandez A, Pujol-Moix N. Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin. Hepatogastroenterology 2000; 47: 1404-1406
2. Fujii H, Kitada T, Yamada T, Sakaguchi H, Seki S, Hino M. Life-threatening severe immune thrombocytopenia during alpha-interferon therapy for chronic hepatitis C. Hepatogastroenterology 2003; 50: 841-842
3. Dieterich DT, Spivak JL. Hematologic disorders associated with hepatitis C virus infection and their management. Clin Infect Dis 2003; 37: 533-541
4. Zachou K, Liaskos C, Christodoulou DK, Kardasi M, Papadamou G, Gatselis N, Georgiadou SP, Tsianos EV, Dalekos GN. Anti-cardiolipin antibodies in patients with chronic viral hepatitis are independent of beta2-glycoprotein I cofactor or features of antiphospholipid syndrome. Eur J Clin Invest 2003; 33: 161-168
5. Schoffski P, Tacke F, Trautwein C, Martin MU, Caselitz M, Hecker H, Manns MP, Ganser A. Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease. Liver 2002; 22: 114-120
6. Fusegawa H, Shiraishi K, Ogasawara F, Shimizu M, Haruki Y, Miyachi H, Matsuzaki S, Ando Y. Platelet activation in patients with chronic hepatitis C. Tokai J Exp Clin Med 2002; 27: 101-106
7. Rocks SA, Davies CA, Hicks SL, Webb AJ, Klocke R, Timmins GS, Johnston A, Jawad AS, Blake DR, Benjamin N, Winyard PG. Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry. Free Radic Biol Med 2005; 39: 937-948
8. Dalle-Donne I, Giustarini D, Colombo R, Milzani A, Rossi R. S-glutathionylation in human platelets by a thiol-disulfide exchange-independent mechanism. Free Radic Biol Med 2005; 38: 1501-1510
9. McNaughton L, Radomski A, Sawich G, Radomski W. Regulation of platelet function. In: Mayer B. Handbook of experimental pharmacology: nitric oxide. Philadelphia: Lippincott Williams & Wilkins, 2000: 235-257
10. Cirino G. Nitric oxide releasing drugs: from bench to bedside. Dig Liver Dis 2003; 35 Suppl 2: S2-S8
11. Miller MR, Hanspal IS, Hadoke PW, Newby DE, Rossi AG, Webb DJ, Megson IL. A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury. Cardiovasc Res 2003; 57: 853-860
12. Jourd'heuil D, Hallen K, Feelisch M, Grisham MB. Dynamic state of S-nitrosothiols in human plasma and whole blood. Free Radic Biol Med 2000; 28: 409-417
13. Wang K, Zhang W, Xian M, Hou YC, Chen XC, Cheng JP, Wang PG. New chemical and biological aspects of S-nitrosothiols. Curr Med Chem 2000; 7: 821-834
14. Crane MS, Ollosson R, Moore KP, Rossi AG, Megson IL. Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function. J Biol Chem 2002; 277: 46858-46863
15. Allen JD, Cobb FR, Gow AJ. Regional and whole-body markers of nitric oxide production following hyperemic stimuli. Free Radic Biol Med 2005; 38: 1164-1169
16. Tanaka T, Nakamura H, Yodoi J, Bloom ET. Redox regulation of the signaling pathways leading to eNOS phosphorylation. Free Radic Biol Med 2005; 38: 1231-1242
17. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699
18. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and (15N) nitrate in biological fluids. Anal Biochem 1982; 126: 131-138
19. Wlodek PJ, Kucharczyk J, Sokolowska MM, Milkowski A, Markiewicz A, Smolenski OB, Wlodek LB. Alteration in plasma levels of nonprotein sulfhydryl compounds and S-nitrosothiols in chronic renal failure patients. Clin Chim Acta 2003; 327: 87-94
20. Radomski MW, Rees DD, Dutra A, Moncada S. S-nitrosoglutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 1992; 107: 745-749
21. Loguercio C, Del Vecchio Blanco C, Coltorti M, Nardi G. Alteration of erythrocyte glutathione, cysteine and glutathione synthetase in alcoholic and non-alcoholic cirrhosis. Scand J Clin Lab Invest 1992; 52: 207-213
22. Loguercio C, Nardi G, Argenzio F, Aurilio C, Petrone E, Grella A, Del Vecchio Blanco C, Coltorti M. Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease. Alcohol Alcohol 1994; 29: 597-604
23. Loguercio C, Blanco FD, De Girolamo V, Disalvo D, Nardi G, Parente A, Blanco CD. Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease. Alcohol Clin Exp Res 1999; 23: 1780-1784
24. Kurjak M, Koppitz P, Schusdziarra V, Allescher HD. Evidence for a feedback inhibition of NO synthesis in enteric synaptosomes via a nitrosothiol intermediate. Am J Physiol 1999; 277: G875-G884
25. Ji Y, Akerboom TP, Sies H, Thomas JA. S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch Biochem Biophys 1999; 362: 67-78
26. Federico A, Tuccillo C, Terracciano F, D'Alessio C, Galdiero M, Finamore E, D'Isanto M, Peluso L, Del Vecchio Blanco C, Loguercio C. Heat shock protein 27 expression in patients with chronic liver damage. Immunobiology 2005; 209: 729-735
27. Megson IL, Sogo N, Mazzei FA, Butler AR, Walton JC, Webb DJ. Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: implications for anti-thrombotic therapy. Br J Pharmacol 2000; 131: 1391-1398
28. Pignatelli P, Sanguigni V, Paola SG, Lo Coco E, Lenti L, Violi F. Vitamin C inhibits platelet expression of CD40 ligand. Free Radic Biol Med 2005; 38: 1662-1666
29. Marzinzig M, Nussler AK, Stadler J, Marzinzig E, Barthlen W, Nussler NC, Beger HG, Morris SM Jr, Bruckner UB. Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and S-nitrosothiols. Nitric Oxide 1997; 1: 177-189
30. Goldman RK, Vlessis AA, Trunkey DD. Nitrosothiol quantification in human plasma. Anal Biochem 1998; 259: 98-103
31. Lackner C, Struber G, Liegl B, Leibl S, Ofner P, Bankuti C, Bauer B, Stauber RE. Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C. Hepatology 2005; 41: 1376-1382
32. Howard CM, Sexton DJ, Mutus B. S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. Thromb Res 1998; 91: 113-120
33. Gordge MP, Hothersall JS, Noronha-Dutra AA. Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione. Br J Pharmacol 1998; 124: 141-148
34. Poynard T, Bedossa P. Age and platelet count: a simple index for predicting the presence of histological lesions in patients with antibodies to hepatitis C virus. METAVIR and CLINIVIR Cooperative Study Groups. J Viral Hepat 1997; 4: 199-208
35. Ono E, Shiratori Y, Okudaira T, Imamura M, Teratani T, Kanai F. Platelet count reflects stage of chronic hepatitis C. Hepatol Res 1999; 15: 192-200
36. Pohl A, Behling C, Oliver D, Kilani M, Monson P, Hassanein T. Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection. Am J Gastroenterol 2001; 96: 3142-3146
37. Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, Lok AS. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003; 38: 518-526
38. Kots AY, Grafov MA, Khropov YV, Betin VL, Belushkina NN, Busygina OG, Yazykova MY, Ovchinnikov IV, Kulikov AS, Makhova NN, Medvedeva NA, Bulargina TV, Severina IS. Vasorelaxant and antiplatelet activity of 4,7-dimethyl-l,2, 5-oxadiazolo(3,4-d)pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols. Br J Pharmacol 2000; 129: 1163-1177
39. Simon DI, Stamler JS, Jaraki O, Keaney JF, Osborne JA, Francis SA, Singel DJ, Loscalzo J. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb 1993; 13: 791-799
40. Pigazzi A, Heydrick S, Folli F, Benoit S, Michelson A, Loscalzo J. Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem 1999; 274: 14368-14375
41. Tsikas D, Ikic M, Tewes KS, Raida M, Frolich JC. Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets. FEBS Lett 1999; 442: 162-166
42. Ikarugi H, Inoue A, Yamashita T, Tsuda Y, Okada Y, Ishii H, Yamamoto J. Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor. Thromb Res 2005; 116: 403-408
43. Hirayama A, Noronha-Dutra AA, Gordge MP, Neild GH, Hothersall JS. S-nitrosothiols are stored by platelets and released during platelet-neutrophil interactions. Nitric Oxide 1999; 3: 95-104
44. Laurent A, Nicco C, Tran Van Nhieu J, Borderie D, Chereau C, Conti F, Jaffray P, Soubrane O, Calmus Y, Weill B, Batteux F. Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis. Hepatology 2004; 39: 1277-1285
45. Lima ES, Bonini MG, Augusto O, Barbeiro HV, Souza HP, Abdalla DS. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radic Biol Med 2005; 39: 532-539
46. Kaplanski G, Farnarier C, Payan MJ, Bongrand P, Durand JM. Increased levels of soluble adhesion molecules in the serum of patients with hepatitis C. Correlation with cytokine concentrations and liver inflammation and fibrosis. Dig Dis Sci 1997; 42: 2277-2284
47. Laffi G, Foschi M, Masini E, Simoni A, Mugnai L, La Villa G, Barletta G, Mannaioni PF, Gentilini P. Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation. Hepatology 1995; 22: 1666-1673
48. Chou DS, Hsiao G, Shen MY, Tsai YJ, Chen TF, Sheu JR. ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets. Free Radic Biol Med 2005; 39: 237-248
49. Richardson G, Hicks SL, O'Byrne S, Frost MT, Moore K, Benjamin N, McKnight GM. The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans. Nitric Oxide 2002; 7: 24-29
50. Al-Sa'doni HH, Khan IY, Poston L, Fisher I, Ferro A. A novel family of S-nitrosothiols: chemical synthesis and biological actions. Nitric Oxide 2000; 4: 550-560