A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Cardiovascular Research

Volumn 57, Issue 3, 2003, Pages 853-860

  Miller, Mark R ^a   Hanspal, Inderraj S ^a   Hadoke, Patrick W F ^a   Newby, David E ^a   Rossi, Adriano G ^b   Webb, David J ^a   Megson, Ian L ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Angioplasty; Arteries; Nitric oxide; Platelets

Indexed keywords

ANTITHROMBOCYTIC AGENT; GLYCERYL TRINITRATE; NITRIC OXIDE DONOR; PENICILLAMINE DERIVATIVE; S NITROSO N VALERYLPENICILLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD PRESSURE; CAROTID ARTERY INJURY; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXPERIMENTAL MODEL; IN VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

ANGIOPLASTY, BALLOON; ANIMALS; BLOOD PLATELETS; BLOOD PRESSURE; CAROTID ARTERY INJURIES; CAROTID ARTERY, COMMON; MALE; MICROSCOPY, ELECTRON, SCANNING; NITROGLYCERIN; PENICILLAMINE; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 0037371739     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00779-4     Document Type: Article

References (33)

1. Wei-Liu M., Roubin G.S., King S.B. Restenosis after coronary angioplasty: potential biologic determinants and role of intimal hyperplasia. Circulation. 79:1989;1374-1387.
2. Lincoff A.M., Topol E.J., Ellis S.G. Local drug delivery for the prevention of restenosis. Fact, fancy, and future. Circulation. 90:1994;2070-2084.
3. Clowes A.W., Karnovsky M.J. Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat. Lab Invest. 36:1977;452-464.
4. Groves H.M., Kinlough-Rathbone R.L., Richardson M., Moore S., Mustard J.F. Platelet interaction with damaged rabbit aorta. Lab Invest. 40:1979;194-200.
5. Fingerle J., Johnson R., Clowes A.W., Majesky M.W., Reidy M.A. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci USA. 86:1989;8412-8416.
6. Topol E.J., Serruys P.W. Frontiers in interventional cardiology. Circulation. 98:1998;1802-1820.
7. Bult H. Restenosis: A challenge for pharmacology. Trends Pharmacol Sci. 21:2000;274-279.
8. Swanson N., Stephens-Lloyd A., Gershlick A. Drug-eluting stents: From lab bench to bedside. Cardiol News. 4:2001;12-15.
9. Langford E.J., Brown A.S., Wainwright R.J., et al. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty. Lancet. 344:1994;1458-1460.
10. Groves P., Lewis M.J., Cheadle H.A., Penny W.J. SIN-1 reduces platelet adhesion and platelet thrombus formation in a porcine model of balloon angioplasty. Circulation. 87:1993;590-597.
11. Lam J.Y.T., Chesebro J.H., Fuster V. Platelets, vasoconstriction, and nitroglycerin during arterial wall injury: A new antithrombotic role for an old drug. Circulation. 78:1988;712-716.
12. De Belder A.J., MacAllister R., Radomski M.W., Moncada S., Vallance P.J.T. Effects of S-nitroso-glutathione in the human forearm circulation: Evidence for selective inhibition of platelet activation. Cardiovasc Res. 28:1994;691-694.
13. Megson I.L., Morton S., Greig I.R., et al. N-Substituted analogues of S-nitroso-N-acetyl-DL-penicillamine: Chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries. Br J Pharmacol. 126:1999;639-648.
14. Miller M.R., Roseberry M.J., Mazzei F.A., et al. Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries. Eur J Pharmacol. 408:2000;335-343.
15. Hadoke P., Wainwright C.L., Wadsworth R.M., Butler K., Giddings M.J. Characterization of the morphological and functional alterations in rabbit subclavian artery subjected to balloon angioplasty. Coron Art Dis. 6:1995;403-415.
16. Bennett B.M., Leitman D.C., Schroder H., et al. Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines. J. Pharmacol. Exp. Ther. 250:1989;316-323.
17. Norman K.E., Williams T.J., Rossi A.G. Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: Effects of the long-acting PAF antagonist UK-74,505. Br J Pharmacol. 120:1997;1286-1293.
18. Megson I.L., Sogo N., Mazzei F.A., et al. Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: Implications for anti-thrombotic therapy. Br J Pharmacol. 131:2000;1391-1398.
19. Sogo N., Magid K.S., Shaw C.A., Webb D.J., Megson I.L. Inhibition of human platelet aggregation by nitric oxide donor drugs: Relative contribution of cGMP-independent mechanisms. Biochem Biophys Res Commun. 279:2000;412-419.
20. Friedman R.J., Stemerman M.B., Wenz B., et al. The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. J Clin Invest. 60:1977;1191-1201.
21. Groves H.M., Kinlough-Rathbone R.L., Mustard J.F. Development of nonthrombogenicity of injured rabbit aortas despite inhibition of platelet adherence. Arteriosclerosis. 6:1986;189-195.
22. Wolinsky H. Local delivery: Let's keep our eyes on the wall. J Am Coll Cardiol. 24:1994;825-827.
23. Sousa J.E., Costa M.A., Abizaid A.C., et al. Sustained suppression of neointimal proliferation by sirolimus-eluting stents: One-year angiographic and intravascular ultrasound follow-up. Circulation. 104:2001;2007-2011.
24. Megson I.L. Nitric oxide donor drugs. Drugs Future. 25:2000;701-715.
25. Marks D.S., Vita J.A., Folts J.D., et al. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. J Clin Invest. 96:1995;2630-2638.
26. Megson I.L., Webb D.J. Nitrate resistance in platelets from patients with stable angina pectoris. Circulation. 102:2000;E87.
27. Weber A.-A., Neuhaus T., Seul C., et al. Biotransformation of glyceryl trinitrate by blood platelets as compared to vascular smooth muscle cells. Eur. J. Pharmacol. 309:1996;209-213.
28. Folts J.D., Stamler J., Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation. 83:1991;2122-2127.
29. MacAllister R.J., Calver A.L., Riezebos J., Collier J., Vallance P. Relative potency of nitrovasodilators on human blood vessels: An insight into the targeting of nitric oxide delivery. J Pharmacol Exp Ther. 273:1995;1529-1537.
30. Sogo N., Campanella C., Webb D.J., Megson I.L. S-Nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery. Br J Pharmacol. 131:2000;1236-1244.
31. Sogo N., Wilkinson I.B., MacCallum H., et al. A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium. Clin Pharmacol Ther. 68:2000;75-81.
32. Dewanjee M.K., Tago M., Josa M., Fuster V., Kaye M.P. Quantification of platelet retention in aortocoronary femoral vein bypass graft in dogs treated with dipyridamole and aspirin. Circulation. 69:1984;350-356.
33. Megson I.L., Greig I.R., Gray G.A., Webb D.J., Butler A.R. Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: Potential as a slow release nitric oxide donor drug. Br J Pharmacol. 122:1997;1617-1624.