Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: Role of soluble guanylate cyclase, nitric oxide and thiols

British Journal of Pharmacology

Volumn 129, Issue 6, 2000, Pages 1163-1177

  Kots, Alexander Ya ^a   Grafov, Mikhail A ^a   Khropov, Yuri V ^a   Betin, Vasily L ^a   Belushkina, Natalya N ^b   Busygina, Olga G ^b   Yazykova, Marina Yu ^a   Ovchinnikov, Igor V ^c   Kulikov, Alexander S ^c   Makhova, Nina N ^c   Medvedeva, Natalya A ^a   Bulargina, Tamara V ^a   Severina, Irina S ^b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^c N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

1,2,5 Oxadiazole; Cyclic GMP; Furoxan; Nitric oxide; Nitroxyl; Platelet aggregation; Pyridazine di N oxide; S nitrosothiols; Soluble guanylate cyclase; Vasorelaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4,7 DIMETHYL 1,2,5 OXADIAZOLO[3,4D]PYRIDAZINE 1,5,6 TRIOXIDE; ADENOSINE DIPHOSPHATE; CYCLIC GMP; DITHIOTHREITOL; GLUTATHIONE; GUANYLATE CYCLASE; HEME; HYDROXYLAMINE; METHEMOGLOBIN; NITRIC OXIDE; NITRITE; NORADRENALIN; OXYHEMOGLOBIN; PYRIDAZINE DERIVATIVE; THIOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA; ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; VASODILATATION;

EID: 0034100646     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703156     Document Type: Article

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